Search results for ACTB

Showing 13 results out of 13

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Species

Types

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Interactor (2 results from a total of 2)

Identifier: EBI-5276484
Species: Homo sapiens
Primary external reference: IntAct: EBI-5276484
Identifier: Q562R1
Species: Homo sapiens
Primary external reference: UniProt: Q562R1

Protein (5 results from a total of 5)

Identifier: R-HSA-390462
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: ACTB: P60709
Identifier: R-HSA-201861
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: ACTB: P60709
Identifier: R-HSA-3321990
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: ACTB: P60709
Identifier: R-HSA-196016
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: ACTB: P60709
Identifier: R-HSA-196160
Species: Homo sapiens
Compartment: lysosomal membrane
Primary external reference: UniProt: ACTB: P60709

RNA Sequence (1 results from a total of 1)

Identifier: R-HSA-428322
Species: Homo sapiens
Compartment: cytosol
Primary external reference: ENSEMBL: Beta-actin mRNA isoform 001: ENST00000331789

Reaction (4 results from a total of 4)

Identifier: R-HSA-3321975
Species: Homo sapiens
Compartment: nucleoplasm
The NuA4 complex contains the histone acetyltransferase (HAT) KAT5 (TIP60), a member of the MYST family. The first characterisation of a mammalian NuA4 complex identified the additonal components TRRAP, the Enhancer of Polycomb protein (EPC1), actin-like protein ACTL6A (BAF53a), which is a homolog of yeast Arp4, actin (ACTB), the SNF2-related helicase p400 (EP400) and the AAA ATPases RUVBL1 (TIP49a) and RUVBL2 (TIP49b) (Ikura et al. 2000). Subsequently further copmponents were identified as MRGBP, MORF4L1 (MRG15), MORF4L2 (MRGX), (Cai et al. 2003), BRD8, DMAP1, ING3, MEAF6, YEATS4 (Doyon et al. 2004) and VPS72 (YL1) (Cai et al. 2005).
Identifier: R-NUL-4551334
Species: Gallus gallus, Homo sapiens
Compartment: nucleoplasm
The NuA4 complex contains the histone acetyltransferase (HAT) KAT5 (TIP60), a member of the MYST family. The first characterisation of a mammalian NuA4 complex identified the additonal components TRRAP, the Enhancer of Polycomb protein (EPC1), actin-like protein ACTL6A (BAF53a), which is a homolog of yeast Arp4, actin (ACTB), the SNF2-related helicase p400 (EP400) and the AAA ATPases RUVBL1 (TIP49a) and RUVBL2 (TIP49b) (Ikura et al. 2000). Subsequently further copmponents were identified as MRGBP, MORF4L1 (MRG15), MORF4L2 (MRGX), (Cai et al. 2003), BRD8, DMAP1, ING3, MEAF6, YEATS4 (Doyon et al. 2004) and VPS72 (YL1) (Cai et al. 2005).
Identifier: R-HSA-9693198
Species: Homo sapiens
Compartment: cytosol, plasma membrane
Active GTP bound RHOD binds to the following effectors at the plasma membrane:
DIAPH1 (Kyrkou et al. 2013)
PAK6 (Durkin et al. 2017)

The following candidate RHOD effectors that can localize to plasma membrane and cytosol were reported in the high throughput screen by Bagci et al. 2020:
ACTN1 (Bagci et al. 2020)
ADD3 (Bagci et al. 2020)
AKAP12 (Bagci et al. 2020)
ARHGAP1 (Bagci et al. 2020)
ARHGAP39 (Bagci et al. 2020)
CAPZB (Bagci et al. 2020)
CAV1 (Bagci et al. 2020)
CPNE8 (Bagci et al. 2020)
DBN1 (Bagci et al. 2020)
DIAPH3 (Bagci et al. 2020)
EFHD2 (Bagci et al. 2020)
ESYT1 (Bagci et al. 2020)
LMNB1 (Bagci et al. 2020)
MCAM (Bagci et al. 2020)
RAB7A (Bagci et al. 2020)
SLC4A7 (Bagci et al. 2020)
STBD1 (Bagci et al. 2020)
STEAP3 (Bagci et al. 2020)
TMPO (Bagci et al. 2020)
TOR1AIP1 (Bagci et al. 2020)
VAMP3 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)

The following putative effectors do not bind to active RHOD:
ACTB (Bagci et al. 2020)
BASP1 (Bagci et al. 2020)
FAM169A (Bagci et al. 2020)
MTMR1 (Bagci et al. 2020)
POTEE (Bagci et al. 2020)
SENP1 (Bagci et al. 2020)
SNAP23 (Bagci et al. 2020)
SOWAHC (Bagci et al. 2020)
Identifier: R-HSA-9693125
Species: Homo sapiens
Compartment: plasma membrane, cytosol
Active GTP bound RHOF binds the following effectors:
BAIAP2L1 (Sudhaharan et al. 2016)
BAIAP2L2 (Sudhaharan et al. 2016)
DIAPH1 (Fan et al. 2010)
DIAPH2 (Gorelik et al. 2011)
FARP1 (Fan et al. 2015)

The following candidate RHOF effectors that can localize to cytosol or the plasma membrane were reported by Bagci et al. 2020 to bind active RHOF:
ACTB (Bagci et al. 2020)
ACTN1 (Bagci et al. 2020)
ADD3 (Bagci et al. 2020)
AKAP12 (Bagci et al. 2020)
ARHGAP1 (Bagci et al. 2020)
ARHGAP39 (Bagci et al. 2020)
BASP1 (Bagci et al. 2020)
CAPZB (Bagci et al. 2020)
CAV1 (Bagci et al. 2020)
CPNE8 (Bagci et al. 2020)
DIAPH3 (Bagci et al. 2020)
ESYT1 (Bagci et al. 2020)
FAM169A (Bagci et al. 2020)
LMNB1 (Bagci et al. 2020)
MCAM (Bagci et al. 2020)
MTMR1 (Bagci et al. 2020)
POTEE (Bagci et al. 2020)
RAB7A (Bagci et al. 2020)
SENP1 (Bagci et al. 2020)
SLC4A7 (Bagci et al. 2020)
SNAP23 (Bagci et al. 2020)
SOWAHC (Bagci et al. 2020)
STEAP3 (Bagci et al. 2020)
TMPO (Bagci et al. 2020)
TOR1AIP1 (Bagci et al. 2020)
VAMP3 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)

Several putative effectors that localize to endoplasmic reticulum, endosomes or the mitochondrial outer membrane were reported to bind active RHOF by Bagci et al. 2020, but as the localization of RHOF to these cellular compartments has not been established, these effectors have not been annotated:
EMD
LBR
LEMD3
LMAN1
PGRMC2
VRK2

The following putative effectors were reported not to bind active RHOF:
DBN1 (Bagci et al. 2020)
EFHD2 (Bagci et al. 2020)
GOLGA8R (Bagci et al. 2020)
HINT2 (Bagci et al. 2020)
MOSPD2 (Bagci et al. 2020)
STBD1 (Bagci et al. 2020)
VAPB (Bagci et al. 2020)

Icon (1 results from a total of 1)

Species: Homo sapiens
Curator: Steve Jupe
Designer: Cristoffer Sevilla
ACTB icon
Actin, cytoplasmic 1
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