Search results for ADCY8

Showing 5 results out of 5

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Species

Types

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Species

Types

Compartments

Reaction types

Search properties

Protein (1 results from a total of 1)

Identifier: R-HSA-53245
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: ADCY8: P40145

Reaction (2 results from a total of 2)

Identifier: R-HSA-442715
Species: Homo sapiens
Compartment: plasma membrane, cytosol
Based on studies in rat neurons, Ca2+ influx through NMDA receptors in the post-synaptic neuron results in activation of adenylate cyclase (Chetkovich et al. 1991), which is mediated by binding of activated calmodulin (CALM1:4xCa2+) to adenylate cyclase (Chetkovich and Sweatt 1993). Two adenylate cyclase isoforms, ADCY1 (AC1) and ADCY8 (AC8), are activated by calmodulin and involved in NMDA receptor-mediated long term potentiation (LTP), which plays a role in learning and memory (Xia et al. 1991, Cali et al. 1994, Wong et al. 1999, Wei et al. 2002, Nicol et al. 2005, Conti et al. 2007). Activated ADCY1 and ADCY8 produce cAMP, which further activates PKA.
Identifier: R-HSA-9617535
Species: Homo sapiens
Compartment: cytosol, plasma membrane
Calmodulin (CALM1, also known as CaM), activated by binding to Ca2+ ions, forms a complex with adenylate cyclase 1 (ADCY1, also known as AC1) (Levin and Reed 1995, Masada et al. 2012) or adenylate cyclase 8 (ADCY8, also known as AC8) (Gu and Cooper 1999, Masada et al. 2012, Herbst et al. 2013), thereby activating them.

Set (1 results from a total of 1)

Identifier: R-HSA-443461
Species: Homo sapiens
Compartment: plasma membrane

Complex (1 results from a total of 1)

Identifier: R-HSA-9617533
Species: Homo sapiens
Compartment: plasma membrane
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