Search results for AGK

Showing 8 results out of 8

×

Species

Types

Compartments

Reaction types

Search properties

Species

Types

Compartments

Reaction types

Search properties

Protein (3 results from a total of 3)

AGK

Identifier: R-HSA-5696027
Species: Homo sapiens
Compartment: mitochondrial outer membrane
Primary external reference: UniProt: AGK: Q53H12
Identifier: R-HSA-6802510
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: AGK: Q53H12
Identifier: R-HSA-6802260
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: Q53H12

Interactor (1 results from a total of 1)

Identifier: Q53H12-2
Species: Homo sapiens
Primary external reference: UniProt: Q53H12-2

Complex (3 results from a total of 3)

Identifier: R-HSA-6802678
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-6802565
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-5696053
Species: Homo sapiens
Compartment: mitochondrial outer membrane

Reaction (1 results from a total of 1)

Identifier: R-HSA-5696074
Species: Homo sapiens
Compartment: mitochondrial outer membrane, mitochondrial intermembrane space
The bioactive phospholipids lysophosphatidic acid (LPA) and phosphatidic acid (PA) regulate processes related to cancer pathogenesis. Mitochondrial acylglycerol kinase (AGK) can phosphorylate both monoacylglycerol (MAG) and diacylglycerol (DAG) in the mitochondrial intermembrane space to form LPA and PA, respectively thus may play an important role in the pathophysiology of certain cancers (Bektas et al. 2005). AGK is mitochondrial outer membrane-bound (Hung et al. 2014) and requires Mg2+ as cofactor.
Defects in AGK can cause mitochondrial DNA depletion syndrome 10 (MTDPS10 aka Sengers syndrome; MIM:212350), an autosomal recessive mitochondrial disorder characterized by congenital cataracts, hypertrophic cardiomyopathy, skeletal myopathy, exercise intolerance, and lactic acidosis. Mental development is normal, but affected individuals may die early from cardiomyopathy (Sengers et al. 1975, Mayr et al. 2012).
Cite Us!