Search results for AHCY

Showing 18 results out of 21

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Species

Types

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Reaction types

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Protein (6 results from a total of 7)

Identifier: R-HSA-174373
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: AHCY: P23526
Identifier: R-HSA-5579042
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: AHCY: P23526
Identifier: R-HSA-5579098
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: P23526
Identifier: R-HSA-5215973
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: AHCYL1: O43865
Identifier: R-HSA-8878665
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: AHCYL2: Q96HN2
Identifier: R-HSA-8853121
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P21802

Complex (6 results from a total of 8)

Identifier: R-HSA-9638053
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-9638054
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-174357
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-5226942
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Identifier: R-HSA-174358
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-5226920
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane

Set (1 results from a total of 1)

Identifier: R-HSA-5579035
Species: Homo sapiens
Compartment: cytosol

Pathway (1 results from a total of 1)

Identifier: R-HSA-5578997
Species: Homo sapiens
Adenosylhomocysteinase (AHCY) is a tetrameric, NAD+-bound, cytosolic protein that regulates all adenosylmethionine (AdoMet) dependent transmethylations by hydrolysing the feedback inhibitor adenosylhomocysteine (AdoHcy) to homocysteine (HCYS) and adenosine (Ade-Rib). Defects in AHCY cause Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD; MIM:613752), a metabolic disorder characterised by hypermethioninemia associated with failure to thrive, psychomotor retardation, facial dysmorphism with abnormal hair and teeth and myocardiopathy (Baric et al. 2004).

Reaction (4 results from a total of 4)

Identifier: R-HSA-2408532
Species: Homo sapiens
Compartment: cytosol
Adenosylhomocysteinase (AHCY) is involved in the hydrolysis of adenosylselenohomocysteine (AdeSeHCys) into adenosine and selenohomocysteine (SeHCys). This reaction is inferred from the event in rat involving the protein adenosylhomocysteinase (Ahcy) (Kajander et al. 1991, Kajander and Raina 1981).
Identifier: R-HSA-5579084
Species: Homo sapiens
Compartment: cytosol
Adenosylhomocysteinase (AHCY) is a tetrameric, NAD+-bound, cytosolic protein that regulates all adenosylmethionine-(AdoMet) dependent transmethylations by hydrolysing the feedback inhibitor adenosylhomocysteine (AdoHcy) to homocysteine (HCYS) and adenosine (Ade-Rib) (Turner et al. 1998, Yang et al. 2003). Defects in AHCY cause Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD; MIM:613752), a metabolic disorder characterised by hypermethioninemia associated with failure to thrive, psychomotor retardation, facial dysmorphism with abnormal hair and teeth and myocardiopathy. Gene analysis revealed two mutations that can cause HMAHCHD; W112* and Y143C (Baric et al. 2004).
Identifier: R-HSA-174401
Species: Homo sapiens
Compartment: cytosol
Adenosylhomocysteinase (AHCY) is a tetrameric, NAD+-bound, cytosolic protein that regulates all adenosylmethionine-(AdoMet) dependent transmethylations by hydrolysing the feedback inhibitor adenosylhomocysteine (AdoHcy) to homocysteine (HCYS) and adenosine (Ade-Rib) (Turner et al. 1998, Yang et al. 2003).
Identifier: R-HSA-5226904
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane, endoplasmic reticulum lumen
Putative adenosylhomocysteinase 2 (AHCYL1 aka adenosylhomocysteine hydrolase-like protein 1) (Dekker et al. 2002) possesses 50% homology to adenosylhomocysteine hydrolase (AHCY), an enzyme important for metabolizing S-adenosyl-l-homocysteine. AHCYL1 can bind to the inositol 1,4,5-trisphosphate receptor (ITPR1) tetramer, suggesting that AHCYL1 is involved in modulating intracellular calcium release (Cooper et al. 2006).
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