Search results for AHCYL1

Showing 10 results out of 10

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Species

Types

Compartments

Reaction types

Search properties

Protein (3 results from a total of 3)

AHCYL1

Identifier: R-HSA-5215973
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: AHCYL1: O43865

FGFR2(22-767)-AHCYL1(108-530) fusion

Identifier: R-HSA-8853158
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P21802

p-6Y FGFR2(22-767)-AHCYL1(108-530) fusion

Identifier: R-HSA-8853121
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P21802

Complex (4 results from a total of 4)

AHCYL1:NAD+

Identifier: R-HSA-5226942
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane

AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer

Identifier: R-HSA-5226920
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane

p-6Y FGFR2(22-767)-AHCYL1(108-530) fusion dimer

Identifier: R-HSA-8853219
Species: Homo sapiens
Compartment: plasma membrane

FGFR2(22-767)-AHCYL1(108-530) fusion dimer

Identifier: R-HSA-8853176
Species: Homo sapiens
Compartment: plasma membrane

Reaction (2 results from a total of 2)

AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it

Identifier: R-HSA-5226904
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane, endoplasmic reticulum lumen
Putative adenosylhomocysteinase 2 (AHCYL1 aka adenosylhomocysteine hydrolase-like protein 1) (Dekker et al. 2002) possesses 50% homology to adenosylhomocysteine hydrolase (AHCY), an enzyme important for metabolizing S-adenosyl-l-homocysteine. AHCYL1 can bind to the inositol 1,4,5-trisphosphate receptor (ITPR1) tetramer, suggesting that AHCYL1 is involved in modulating intracellular calcium release (Cooper et al. 2006).

FGFR2 fusions autophosphorylate

Identifier: R-HSA-8853313
Species: Homo sapiens
Compartment: plasma membrane
FGFR2 fusions in cholangiocarcinoma and cancers of the breast, lung and thyroid have been shown to promote anchorage independent growth, cellular proliferation and tumorigenesis. In some cases, such as for FGFR2-AHCYL1 and FGFR2-BICC1 fusions in cholangiocarcinoma, these activities have been shown to depend on the FGFR2 kinase domain, suggesting that the fusions undergo autophosphorylation after oligomerization, as is the case for WT FGFR2. FGFR2 fusions, where tested, also show sensitivity to kinase inhibitors such as PD173074 and pazopanib (Arai et al, 2013; Wu et al, 2013; Seo et al, 2012; reviewed in Parker et al, 2014).

Pathway (1 results from a total of 1)

Signaling by FGFR2 fusions

Identifier: R-HSA-8853333
Species: Homo sapiens
FGFR2 fusions have been identified in cancers such as lung, breast, thyroid and cholangiocarcinoma (Wu et al, 2013; Seo et al, 2012; Arai et al, 2013). Of all the FGF receptors, FGFR2 shows the broadest range of 3' fusion partners, including BICC1, AHCYL1, CIT, CCDC6, CASP7, AFF3, OFD1 and CCAR2. Many of these fusion partners contain dimerization domains, suggesting that the resulting fusions may demonstrate constitutive ligand-independent activation (Wu et al, 2013; Arai et al, 2013; Seo et al, 2012; reviewed in Parker et al, 2014).
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