Search results for AKAP5

Showing 17 results out of 18

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Species

Types

Compartments

Reaction types

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Protein (2 results from a total of 2)

Identifier: R-HSA-416331
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: AKAP5: P24588
Identifier: R-HSA-381669
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: P24588

Pathway (1 results from a total of 1)

Identifier: R-HSA-9010642
Species: Homo sapiens
AKAP5 (also known as AKAP79 in humans and Akap150 in mice) is an A-kinase anchoring protein which is able to bind to ROBO receptors ROBO2 and ROBO3.1, an isoform of ROBO3, by interacting with their cytoplasmic tails. The interaction was originally detected between endogenous proteins from the mouse brain lysates. AKAP5 can recruit protein kinase A (PKA), protein kinase C (PKC) and protein phosphatase PP2B to ROBO2. AKAP5-mediated recruitment of PKC to ROBO3.1 leads to phosphorylation of ROBO3.1 by PKC. Functional implications of AKAP5 interaction with ROBO receptors are not known (Samelson et al. 2015).

Reaction (7 results from a total of 7)

Identifier: R-HSA-9010643
Species: Homo sapiens
Compartment: cytosol
Based on studies in mice, AKAP5 (also known as AKAP79) recruits activated protein kinase C - PRKCA and possibly other isoforms - to the ROBO2 receptor. This interaction was also confirmed using recombinant human AKAP5 and mouse Robo2 (Samelson et al. 2015).
Identifier: R-HSA-9010647
Species: Homo sapiens
Compartment: plasma membrane
AKAP5 (also known as AKAP79) forms a complex with the ROBO3 receptor isoform ROBO3.1 (Samelson et al. 2015).
Identifier: R-HSA-9010646
Species: Homo sapiens
Compartment: plasma membrane
AKAP5 (also known as AKAP79) recruits activated protein kinase C - PRKCA and possibly other isoforms - to the ROBO3 receptor isoform ROBO3.1 (Samelson et al. 2015).
Identifier: R-HSA-9010641
Species: Homo sapiens
Compartment: cytosol, plasma membrane
Based on studies in mice, AKAP5 (also known as AKAP79) recruits protein kinase A (PKA) to the ROBO2 receptor, by interacting with the PKA regulatory subunit RIIalpha (Samelson et al. 2015).
Identifier: R-HSA-9010648
Species: Homo sapiens
Compartment: plasma membrane
Based on studies in mice, AKAP5 (also known as AKAP79), an A-kinase anchoring protein, forms a complex with ROBO2. The interaction involves the intracellular domain of ROBO2. It has not been investigated whether SLIT-mediated activation of ROBO2 is needed for this interaction (Samelson et al. 2015).
Identifier: R-HSA-9010645
Species: Homo sapiens
Compartment: plasma membrane
Based on studies in mice, AKAP5 (also known as AKAP79) recruits protein phosphatase PP2B subunit B (PPP3CB) to ROBO2 receptor. It is not known whether prior binding of PPP3CB to calcium-activated calmodulin is needed for this interaction to occur (Samelson et al. 2015).
Identifier: R-HSA-9010681
Species: Homo sapiens
Compartment: plasma membrane
PKC (PRKCA, and possibly other isoforms), recruited to ROBO3 receptor isoform ROBO3.1 by AKAP5 (AKAP79) phosphorylates ROBO3.1 on serine residue S1330 (Samelson et al. 2015).

Complex (7 results from a total of 8)

Identifier: R-HSA-9010700
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-9010687
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-9010776
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-9010760
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-9010716
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-9010754
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-9010778
Species: Homo sapiens
Compartment: plasma membrane
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