Search results for AKR7A2

Showing 3 results out of 3

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Species

Types

Compartments

Search properties

Protein (1 results from a total of 1)

Identifier: R-HSA-5423681
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: AKR7A2: O43488

Complex (1 results from a total of 1)

Identifier: R-HSA-5423691
Species: Homo sapiens
Compartment: cytosol

Reaction (1 results from a total of 1)

Identifier: R-HSA-5423637
Species: Homo sapiens
Compartment: cytosol
Aflatoxin B1 aldehyde reductases (AKR7A2, AKR7A3 and AKR7L) are dimeric, cytosolic, NADPH-dependent enzymes able to catalyse the reduction of aflatoxin B1 dialdehyde (AFBDHO) to aflatoxin B1-6,8-dialcohol (AFBDOH) (Ellis et al. 2003, Bodreddigari et al. 2008, Ireland et al. 1998, Guengerich et al. 2001). AKRs can turnover a vast range of substrates, including drugs, carcinogens, and reactive aldehydes. They play central roles in the metabolism of these agents, leading to either their bioactivation or detoxication (Jin & Penning 2007). The dialcohol is excreted in urine by conjugation with glucuronide (not shown here).
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