Search results for ALDOA

Showing 8 results out of 8

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Species

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Species

Types

Compartments

Reaction types

Search properties

Protein (6 results from a total of 6)

Identifier: R-HSA-71492
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: ALDOA: P04075
Identifier: R-HSA-6801469
Species: Homo sapiens
Compartment: secretory granule lumen
Primary external reference: UniProt: ALDOA: P04075
Identifier: R-HSA-6801521
Species: Homo sapiens
Compartment: ficolin-1-rich granule lumen
Primary external reference: UniProt: ALDOA: P04075
Identifier: R-HSA-349738
Species: Homo sapiens
Compartment: platelet alpha granule lumen
Primary external reference: UniProt: ALDOA: P04075
Identifier: R-HSA-349735
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: P04075
Identifier: R-HSA-6801485
Species: Homo sapiens
Compartment: tertiary granule lumen
Primary external reference: UniProt: P04075

Interactor (1 results from a total of 1)

Identifier: P04075-2
Species: Homo sapiens
Primary external reference: UniProt: P04075-2

Reaction (1 results from a total of 1)

Identifier: R-HSA-70342
Species: Homo sapiens
Compartment: cytosol
Cytosolic aldolase B (ALDOB) catalyzes the reaction of D-fructose 1-phosphate (Fru 1-P) to form dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde (GA) (Hers & Kusaka 1953; Schapira 1975). The active form of the enzyme is a tetramer (Dalby et al. 2001). Deficiencies in the enzyme are associated with hereditary fructose intolerance in vivo (e.g., Tolan 1995; Ali et al. 1998).
ALDOB is the same aldolase isoform that catalyzes the reversible cleavage of fructose-1,6-bisphosphate in glycolysis. This isoform, found in liver, kidney, and intestine, is approximately equally active with fructose 1 phosphate and fructose 1,6 bisphosphate as substrates at saturating concentrations, while the muscle and brain isoforms (ALDOA and ALDOC, respectively), have little activity with fructose-1-phosphate (Lebherz & Rutter 1969; Penhoet et el. 1969).
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