Search results for AMDHD2

Showing 3 results out of 3

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Species

Types

Compartments

Reaction types

Search properties

Protein (1 results from a total of 1)

Identifier: R-HSA-6803808
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: AMDHD2: Q9Y303

Interactor (1 results from a total of 1)

Identifier: Q9Y303-2
Species: Homo sapiens
Primary external reference: UniProt: Q9Y303-2

Reaction (1 results from a total of 1)

Identifier: R-HSA-6803789
Species: Homo sapiens
Compartment: cytosol
Humans are not able to catalyse the formation of N-glycolylneuraminic acid (Neu5Gc) due to an inactive CMAHP enzyme. Neu5Gc can be obtained from dietary sources and must be degraded to avoid accummulation and resultant chronic inflammation known as xenosialitis (Varki et al. 2011). In the Neu5Gc degradation pathway, the putative N-acetylglucosamine-6-phosphate deacetylase (AMDHD2) is thought to irreversibly hydrolyse N-glycolylglucosamine 6-phosphate (GlcNGc-6-P), resulting in the ubiquitous metabolites glycolate (CCA) and glucosamine 6-phosphate (GlcN6P) (Bergfeld et al. 2012).
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