Search results for APOA1

Showing 20 results out of 34

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Species

Types

Compartments

Reaction types

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Protein (6 results from a total of 12)

Identifier: R-HSA-8956724
Species: Homo sapiens
Compartment: endoplasmic reticulum lumen
Primary external reference: UniProt: APOA1: P02647
Identifier: R-HSA-350761
Species: Homo sapiens
Compartment: secretory granule lumen
Primary external reference: UniProt: APOA1: P02647
Identifier: R-HSA-2429641
Species: Homo sapiens
Compartment: early endosome
Primary external reference: UniProt: APOA1: P02647
Identifier: R-HSA-174720
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: APOA1: P02647
Identifier: R-HSA-2239460
Species: Homo sapiens
Compartment: endocytic vesicle lumen
Primary external reference: UniProt: APOA1: P02647
Identifier: R-HSA-976865
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: APOA1: P02647

DNA Sequence (1 results from a total of 1)

Identifier: R-HSA-5649927
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSG00000118137

Reaction (6 results from a total of 14)

Identifier: R-HSA-1989754
Species: Homo sapiens
Compartment: nucleoplasm, extracellular region
The APOA1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
Identifier: R-HSA-264758
Species: Homo sapiens
Compartment: extracellular region
The six aminoterminal residues of pro-apolipoprotein A-1 are removed to generate the mature, lipid-binding form of the protein (APOA1). Studies of tissue culture systems suggest that BMP1 catalyzes this reaction (Chau et al. 2006, 2007). While BMP1 is annotated here as a monomer, its subunit structure is not known, and its 1:1 association with Zn2+ is inferred from its sequence similarity to known metallopeptidases. Tetrameric alpha2-macroglobulin (A2M) at concentrations found in plasma in inflammatory responses inhibits this reaction in vitro, suggesting a possible link between inflammation and perturbation of HDL function (Zhang et al. 2006, Chau et al. 2007).
Identifier: R-HSA-216727
Species: Homo sapiens
Compartment: extracellular region, plasma membrane
ABCA1 associated with the plasma membrane binds extracellular apolipoprotein A-I (APOA1), forming a membrane-associated complex. The predominant form of ABCA1 is a heterotetramer (Denis et al. 2004), although studies in model systems in vitro are consistent with the hypothesis that the protein may also occur as a dimer (Trompier et al. 2006).
Identifier: R-HSA-6806966
Species: Homo sapiens
Compartment: mitochondrial matrix
NAD(P)H-hydrate epimerase (APOA1BP) is a homodimeric protein located in the mitochondrion (Ritter et al. 2002). Mammalian APOA1BP is able to mediate the epimerisation of the R-form of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (Marbaix et al. 2011). This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
Identifier: R-HSA-2168889
Species: Homo sapiens
Compartment: extracellular region
Haptoglobin-related protein (HRP) is present in human serum in a complex known as trypanosome lytic factor-1 (TLF-1) that contains APOL1, APOA1, and HDL3. The HPR subunit of the complex binds hemoglobin with an unknown stoichiometry (Shiflett et al. 2005, Nielsen et al. 2006, Widener et al. 2007, Harrington et al. 2009).
Identifier: R-HSA-216723
Species: Homo sapiens
Compartment: plasma membrane
In an ATP-dependent reaction, ATP-binding cassette sub-family A member 1 (ABCA1, ATPA1) mediates the movement of intracellular cholesterol to the extracellular face of the plasma membrane. Cholesterol associated with cytosolic vesicles is a substrate for this reaction. Under physiologocal conditions, the active form of ABCA1 is predominantly a tetramer associated with apolipoprotein A-I (APOA1) (Denis et al. 2004; Vedhachalam et al., 2007). The number of lipid molecules transported per ATP consumed is not known.

Complex (5 results from a total of 5)

Identifier: R-HSA-382558
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-2168878
Species: Homo sapiens
Compartment: extracellular region
Identifier: R-HSA-2168857
Species: Homo sapiens
Compartment: extracellular region
Identifier: R-HSA-9631840
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-6807487
Species: Homo sapiens
Compartment: mitochondrial matrix

Pathway (2 results from a total of 2)

Identifier: R-HSA-5682113
Species: Homo sapiens
In an ATP-dependent reaction, ATP-binding cassette sub-family A member 1 (ABCA1) mediates the movement of intracellular cholesterol to the extracellular face of the plasma membrane. Cholesterol associated with cytosolic vesicles is a substrate for this reaction. Under physiologocal conditions, the active form of ABCA1 is post-translationally modified (palmitoylated and phosphorylated), predominantly a tetramer and is associated with apolipoprotein A-I (APOA1). Defects in ABCA1 can cause Tangier disease (TGD; MIM:205400 aka high density lipoprotein deficiency type 1), an autosomal recessive disorder characterised by significantly reduced levels of plasma high density lipoproteins (HDL) resulting in tissue accumulation of cholesterol esters (Brooks-Wilson et al. 1999). Low HDL levels are among the most common biochemical abnormalities observed in coronary heart disease (CHD) patients (Kolovou et al. 2006, Iatan et al. 2008, Iatan et al. 2012).
Identifier: R-HSA-1989781
Species: Homo sapiens
Compartment: cytosol, endoplasmic reticulum membrane, extracellular region, lipid droplet, mitochondrial inner membrane, mitochondrial matrix, mitochondrial outer membrane, nucleoplasm, peroxisomal matrix, peroxisomal membrane, plasma membrane
The set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor elements (PPREs) in their promoters and include:
1) genes involved in fatty acid oxidation and ketogenesis (Acox1, Cyp4a, Acadm, Hmgcs2);
2) genes involved in fatty acid transport (Cd36, , Slc27a1, Fabp1, Cpt1a, Cpt2);
3) genes involved in producing fatty acids and very low density lipoproteins (Me1, Scd1);
4) genes encoding apolipoproteins (Apoa1, Apoa2, Apoa5);
5) genes involved in triglyceride clearance ( Angptl4);
6) genes involved in glycerol metabolism (Gpd1 in mouse);
7) genes involved in glucose metabolism (Pdk4);
8) genes involved in peroxisome proliferation (Pex11a);
9) genes involved in lipid storage (Plin, Adfp).
Many other genes are known to be regulated by PPAR-alpha but whether their regulation is direct or indirect remains to be found. These genes include: ACACA, FAS, SREBP1, FADS1, DGAT1, ABCA1, PLTP, ABCB4, UGT2B4, SULT2A1, Pnpla2, Acsl1, Slc27a4, many Acot genes, and others (reviewed in Rakhshandehroo et al. 2010).
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