Search results for ARG1

Showing 8 results out of 8

×

Species

Types

Compartments

Search properties

Species

Types

Compartments

Search properties

Protein (4 results from a total of 4)

Identifier: R-HSA-6798764
Species: Homo sapiens
Compartment: azurophil granule lumen
Primary external reference: UniProt: ARG1: P05089
Identifier: R-HSA-6806221
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: ARG1: P05089
Identifier: R-HSA-70561
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: ARG1: P05089
Identifier: R-HSA-6801011
Species: Homo sapiens
Compartment: specific granule lumen
Primary external reference: UniProt: P05089

Complex (1 results from a total of 1)

Identifier: R-HSA-70567
Species: Homo sapiens
Compartment: cytosol

Reaction (2 results from a total of 2)

Identifier: R-HSA-70569
Species: Homo sapiens
Compartment: cytosol
Cytosolic Arginase 1 (ARG1) trimer catalyzes the hydrolysis of arginine to yield ornithine and urea (DiCostanzo et al. 2005). Patients expressing mutated forms of the enzyme with diminished in vitro arginase activity can accumulate arginine to pathogenic levels in the blood (e.g., Uchino et al. 1995).
Identifier: R-HSA-452036
Species: Homo sapiens
Compartment: mitochondrial matrix
Arginase 2 (ARG2) trimer catalyzes the hydrolysis of arginine to form urea and ornithine (Cama et al. 2003). ARG2 is localized to the mitochondrion (Gotoh ea 1996). The enzyme is expressed in many tissues in addition to liver and while its function appears to mitigate the effects of ARG1 deficiency on urea synthesis, its normal physiological roles have not been fully defined (Iyer et al. 1998).

Pathway (1 results from a total of 1)

Identifier: R-HSA-70635
Species: Homo sapiens
The urea cycle yields urea, the major form in which excess nitrogen is excreted from the human body, and the amino acid arginine (Brusilow and Horwich 2001). It consists of four reactions: that of ornithine and carbamoyl phosphate to form citrulline, of citrulline and aspartate to form argininosuccinate, the cleavage of argininosuccinate to yield fumarate and arginine, and the cleavage of arginine to yield urea and re-form ornithine. The carbamoyl phosphate consumed in this cycle is synthesized in the mitochondria from bicarbonate and ammonia, and this synthesis in turn is dependent on the presence of N-acetylglutamate, which allosterically activates carbamoyl synthetase I enzyme. The synthesis of N-acetylglutamate is stimulated by high levels of arginine. Increased levels of free amino acids, indicated by elevated arginine levels, thus stimulate urea synthesis.

Two enzymes catalyze the hydrolysis of arginine to yield ornithine and urea. Cytosolic ARG1 is the canonical urea cycle enzyme. Mitochondrial ARG2 likewise catalyzes urea production from arginine and may have a substantial sparing effect in patients lacking ARG1 enzyme, so its reaction is annotated here although the role of ARG2 under normal physiological conditions remains unclear.

Cite Us!