Search results for ARHGDIA

Showing 11 results out of 14

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Species

Types

Compartments

Reaction types

Search properties

Protein (1 results from a total of 1)

Identifier: R-HSA-194478
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: ARHGDIA: P52565

Set (2 results from a total of 2)

Identifier: R-HSA-9012837
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-9014455
Species: Homo sapiens
Compartment: cytosol

Complex (1 results from a total of 1)

Identifier: R-HSA-9014414
Species: Homo sapiens
Compartment: cytosol

Reaction (6 results from a total of 9)

Identifier: R-HSA-9013158
Species: Homo sapiens
Compartment: plasma membrane, cytosol
The following GDP dissociation inhibitors (GDIs) bind to CDC42 and inhibit its activation:
ARHGDIA (Gupta et al. 2013; Murphy et al. 2001)
ARHGDIG (Adra et al. 1997)
ARHGDIB (Adra et al. 1993)
CAV1 (Nevins and Thurmond 2006)
Identifier: R-HSA-9012835
Species: Homo sapiens
Compartment: cytosol, plasma membrane
The following GDP dissociation inhibitors (GDIs) bind to RHOA and inhibit its activation:
ARHGDIA (Boulter et al. 2010; Man et al. 2010; Gupta et al. 2013)
ARHGDIB (Watanabe et al. 2012)

ARHGDIG was shown to bind to RHOA by Adra et al. 1997, but no binding and no RHOA inhibition was detected by Zalcman et al. 1996. ARHGDIG is annotated as a candidate RHOA GDI.
Identifier: R-HSA-9013147
Species: Homo sapiens
Compartment: plasma membrane, cytosol
The following GDP dissociation inhibitors (GDIs) bind to RAC1 and inhibit its activation:
ARHGDIA (Boulter et al. 2010; Gupta et al. 2013; Ando et al. 1992)
ARHGDIB (Adra et al. 1993, Zhang et al. 2009)

ARHGDIG does not act on RAC1 (Zalcman et al. 1996, Adra et al. 1997)
Identifier: R-HSA-9014293
Species: Homo sapiens
Compartment: cytosol, plasma membrane
ARHGDIA, a GDP dissociation inhibitor (GDI) binds to RAC2 and inhibits its activation (Ando et al. 1992). ARHGDIG does not act on RAC2 (Adra et al. 1997).
Identifier: R-HSA-9013108
Species: Homo sapiens
Compartment: cytosol, plasma membrane
ARHGDIA is a GDP dissociation inhibitor (GDI) that binds to RHOC and inhibits it (Boulter et al. 2010; Giang Ho et al. 2011). ARHGDIG does not act on RHOC (Zalcman et al. 1996).
Identifier: R-HSA-9014456
Species: Homo sapiens
Compartment: cytosol, plasma membrane
The following GDP dissociation inhibitors (GDIs) bind to RHOG and inhibit its activation:
ARHGDIA (Elfenbein et al. 2009)
ARHGDIB (Vignal et al. 2001)
ARHGDIG (Zalcman et al. 1996; Brunet et al. 2002)

Pathway (1 results from a total of 1)

Identifier: R-HSA-9013406
Species: Homo sapiens
This pathway catalogues RHOQ (also known as TC10) guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs), and RHOQ effectors. No GDP dissociation inhibitors (GDIs) have been shown to interact with RHOQ. Two GDIs, ARHGDIA (Michaelson et al. 2001; Murphy et al. 2001) and ARHGDIB (Zhang et al. 2009), were specifically shown not to interact with RHOQ. RHOQ, together with RHOJ (TCL), belongs to the CDC42 subfamily of RHO GTPases, with the three family members sharing 70-85% of homology (Donnelly et al. 2014; Shi et al. 2016). RHOQ is highly activated on exocytosing vesicles and recycling endosomes. RHOQ GTPase activity is necessary for fusion of vesicles with the plasma membrane (Donnelly et al. 2014). RHOQ is required for insulin-stimulated glucose uptake (Kanzaki and Pessin 2003; Saltiel and Pessin 2003) and is involved in insulin signaling in adipocytes (Satoh 2014). RHOQ is involved in neurite outgrowth and regulates membrane addition during axon formation (Gonzalez‐Billault et al. 2012).
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