Search results for ASPH

Showing 6 results out of 6

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Species

Types

Compartments

Reaction types

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Species

Types

Compartments

Reaction types

Search properties

Protein (2 results from a total of 2)

Identifier: R-HSA-5490331
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: ASPH: Q12797
Identifier: R-HSA-9631383
Species: Homo sapiens
Compartment: endoplasmic reticulum lumen
Primary external reference: UniProt: ASPH: Q12797

Interactor (2 results from a total of 2)

Identifier: Q12797-6
Species: Homo sapiens
Primary external reference: UniProt: Q12797-6
Identifier: Q12797-7
Species: Homo sapiens
Primary external reference: UniProt: Q12797-7

Complex (1 results from a total of 1)

Identifier: R-HSA-9631382
Species: Homo sapiens
Compartment: endoplasmic reticulum lumen

Reaction (1 results from a total of 1)

Identifier: R-HSA-9631355
Species: Homo sapiens
Compartment: endoplasmic reticulum lumen
ASPH (aspartyl/asparaginyl beta-hydroxylase) 3-hydroxylates aspartate 110 of F9 (clotting factor IX). The active form of the human enzyme is inferred from studies of its bovine homolog to be a monomer complexed with Fe2+ and localized to the endoplasmic reticulum (Wang et al. 1991; Jia et al. 1992). Hydroxylated aspartate residues have been found in F9 and many other proteins with EGF domains (McMullen et al. 1983). The physiological role of this modification has not been determined. F9 has been chosen for annotation here because its reaction with ASPH has been characterized in vitro.
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