Search results for ATP5B

Showing 13 results out of 13

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Protein (6 results from a total of 6)

Identifier: R-HSA-164576
Species: Homo sapiens
Compartment: mitochondrial matrix
Primary external reference: UniProt: ATP5F1B: P06576
Identifier: R-HSA-1299441
Species: Homo sapiens
Compartment: mitochondrial inner membrane
Primary external reference: UniProt: ATP5F1B: P06576
Identifier: R-HSA-1267973
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: ATP5F1B: P06576
Identifier: R-HSA-8986172
Species: Homo sapiens
Compartment: mitochondrial matrix
Primary external reference: UniProt: ATP5F1B: P06576
Identifier: R-HSA-1267985
Species: Homo sapiens
Compartment: mitochondrial intermembrane space
Primary external reference: UniProt: ATP5F1B: P06576
Identifier: R-HSA-1299440
Species: Homo sapiens
Compartment: mitochondrial inner membrane
Primary external reference: UniProt: ATP5F1B: P06576

DNA Sequence (1 results from a total of 1)

Identifier: R-HSA-2466389
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSEMBL:ENSG00000110955

Reaction (5 results from a total of 5)

Identifier: R-HSA-1592247
Species: Homo sapiens
Compartment: nucleoplasm, mitochondrial matrix
ERR1 (ERRalpha) probably interacts with PGC-1beta to activate expression of ATP5B (Shao et al. 2010).
The ATP5B (ATP synthase beta subunit) gene is transcribed in the nucleus to yield mRNA and the mRNA is translated in the cytosol to yield the ATP5B precursor, which is then imported into the mitochondrial matrix. ATP5B is a peripheral membrane protein located at the matrix face of the inner membrane within the ATP synthase complex (reviewed in Leyva et al. 2003).
Identifier: R-HSA-2466369
Species: Homo sapiens
Compartment: nucleoplasm
As inferred from mouse, PGC-1beta (PPARGC1B) binds NRF1 and coactivates genes regulated by NRF1.
Identifier: R-HSA-1299482
Species: Homo sapiens
Compartment: mitochondrial inner membrane
As inferred from the yeast TIM23 complex, the human TIMM23 complex resides in the inner membrane of the mitochondrion and transfers precursor proteins to the inner membrane. The presequences of proteins targeted to the inner membrane are transferred to the matrix where they are cleaved. Sequences in the mature regions of the proteins then interact with the TIMM23 complex to halt transfer across the inner membrane and the proteins are released laterally into the inner membrane. TIMM21 is required.
In yeast experimentally verified substrates of the TIM23 complex targeted to the inner membrane include CYB2, DLD (LDHD in human), ATP9 (ATP5G1 in human), COQ2, TIM54 (TIMM54 in human), COX4, COX5A, and ATP2 (ATP5B in human). Many other inner membrane proteins are believed to be substrates of the TIMM23 complex.
Identifier: R-HSA-1299487
Species: Homo sapiens
Compartment: mitochondrial intermembrane space, mitochondrial inner membrane
As inferred from the yeast TIM23 complex, the human TIMM23 complex resides in the inner membrane of the mitochondrion and transfers precursor proteins to the inner membrane. The TIMM23 complex appears to adopt different configurations (and perhaps different subunit compositions) depending on whether the substrate is destined for the inner membrane or the matrix. Here we refer to the TIMM23 SORT complex as the configuration that delivers inner membrane proteins. The TIMM21 subunit is required for this activity. In yeast, the N-terminal presequences of precursors first interact with TIM50 and TIM23 (TIMM50 and TIMM23 in human, Zhang et al. 2013). The TIM17 and TIM23 subunits (TIMM17 and TIMM23 in human) form a channel and are required to initiate translocation of precursors.
In yeast experimentally verified substrates of the TIM23 SORT complex targeted to the inner membrane include CYB2, DLD (LDHD in human), ATP9 (ATP5G1 in human), COQ2, TIM54 (TIMM54 in human), COX4, COX5A, and ATP2 (ATP5B in human). Many other inner membrane proteins are believed to be substrates of the TIMM23 complex.
Identifier: R-HSA-1268022
Species: Homo sapiens
Compartment: cytosol, mitochondrial outer membrane, mitochondrial intermembrane space
As inferred from the yeast TOM40:TOM70 complex, the human TOMM40:TOMM70 complex transports precursor proteins from the cytosol, across the outer membrane of the mitochondrion, and into the intermembrane space from where they may be targeted to all locations within the mitochondrion. As inferred from yeast, TOMM40, TOMM22, TOMM5, TOMM6, and TOMM7 probably form the general import pore across the membrane. On the cytosolic side TOMM20 and TOMM22 interact with presequences on mitochondrial precursors while TOMM70 interacts with hydrophobic sequences in mature internal regions of mitochondrial proteins.
In yeast, experimentally verified substrates of the TOM40:TOM70 complex include ATP1 (ATP5A1 in human), ATP2 (ATP5B in human), ATP9 (ATP5G1 in human), TOM40 (TOMM40 in human), SSC1 (mtHsp70, HSPA9 in human), CIT1 (CS in human), ACO1 (ACO2 in human), IDH1 (IDH3G in human), BCS1 (BCS1L in human), CYT1 (CYC1 in human), TIM54 (TIMM54 in human), TIM22 (TIMM22 in human), AAC (ADP/ATP translocase 1, ANT, SLC25A4 in human), HSP60, and CYB2. In humans, TOMM40 has been shown to be a substrate (Humphries et al. 2005). In yeast some proteins such as ACO1, ATP1, CIT1, IDH1, and ATP2 contain both presequences that interact with TOM20 and mature regions that interact with TOM70 (Yamamoto et al. 2009). Most proteins imported into mitochondria are anticipated to be transported through the TOMM40:TOMM70 complex.

Complex (1 results from a total of 1)

Identifier: R-HSA-2466375
Species: Homo sapiens
Compartment: nucleoplasm
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