Search results for BIRC5

Showing 14 results out of 15

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Protein (3 results from a total of 3)

Identifier: R-HSA-50851
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: BIRC5: O15392
Identifier: R-HSA-4655344
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: BIRC5: O15392
Identifier: R-HSA-8955933
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: BIRC5: O15392

Interactor (2 results from a total of 2)

Identifier: O15392-1
Species: Homo sapiens
Primary external reference: UniProt: O15392-1
Identifier: O15392-2
Species: Homo sapiens
Primary external reference: UniProt: O15392-2

DNA Sequence (2 results from a total of 2)

Identifier: R-HSA-6797760
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSG00000089685
Identifier: R-HSA-8948424
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSG00000089685

Reaction (7 results from a total of 8)

Identifier: R-HSA-6797763
Species: Homo sapiens
Compartment: nucleoplasm
Upon binding to the p53 response element in the promoter of the BIRC5 (survivin) gene, TP53 (p53) inhibits transcription of BIRC5, an inhibitor of apoptosis (Hoffman et al. 2002).
Identifier: R-HSA-6797766
Species: Homo sapiens
Compartment: nucleoplasm
TP53 (p53) binds the p53 response element in the promoter of the BIRC5 (survivin) gene (Hoffman et al. 2002).
Identifier: R-HSA-8956026
Species: Homo sapiens
Compartment: cytosol
One defined target of CUL9 ubiquitin ligase is BIRC5 (also known as Survivin), which has roles in cellular proliferation, inhibition of apoptosis and maintenance of genome stability (Zhao et al, 2000; Watanabe, 2010). Deletion of CUL9 leads to polyploidy, abnormal nuclear morphology and DNA damage and is accompanied by an increase in survivin protein levels (Li et al, 2014). CUL9-mediated ubiquitination of BIRC5 is negatively regulated by the 3M complex, consisting of CUL7, CCDC8 and OBSL1 (Li et al, 2014; Yan et al, 2014). This CUL7-dependent inhibition of CUL9 ubiquitin ligase activity is promoted by heterodimerization between CUL7 and CUL9 (Li et al, 2014).
Identifier: R-HSA-8956025
Species: Homo sapiens
Compartment: cytosol
UBE2M transfers NEDD8 to lysine 1881 of CUL9 (Skaar et al, 2007; Li et al, 2014). Neddylation increases the ubiquitination activity of the E3 complex towards its targets (Hori et al, 1999; Duda et al, 2008). One defined target of CUL9 is BIRC5 (also known as Survivin), which has roles in cellular proliferation, inhibition of apoptosis and maintenance of genome stability (Zhao et al, 2000; Watanabe, 2010). CUL9-mediated ubiquitination of BIRC5 is negatively regulated by the 3M complex, consisting of CUL7, CCDC8 and OBSL1 (Li et al, 2014).
Identifier: R-HSA-8956050
Species: Homo sapiens
Compartment: cytosol
CUL7, CCDC8 and OBSL1 are part of a 3M complex that has roles in maintenace of genome stability and microtubule dynamics (Li et al, 2014; Yan et al, 2014). The 3M complex inhibits CUL9-mediated ubiquitination of BIRC5 through the formation of a CUL9:CUL7 heterodimer (Skaar et al, 2007; Li et al, 2014)
Identifier: R-HSA-8956031
Species: Homo sapiens
Compartment: cytosol
CUL9 (also known as PARC for p53-associated PARkin-like cytoplasmic protein) is an atypical cullin that has been shown to form a ubiquitin ligase complex with RBX1, although other components of the putative CRL9 complex have not yet been identified (Skaar et al, 2007; Li et al, 2014). CUL9:RBX1 is neddylated in vivo, likely through the UBE2M E2 although this hasn't been directly demonstrated (Skaar et al, 2007).
CUL9 is 60% identical to CUL7, another atypical mammalian cullin family member, but more distantly related to CUL1, 2, 3, 4A,4B and 5. CUL9 and CUL7 have been shown to form a heterodimer in vivo, and both interact with p53 (Skaar et al, 2007; Andrews et al, 2006; Nikolaev et al, 2003). CUL9 ubiquitinates BIRC5 (also known as Survivin), a protein with roles in cellular proliferation and inhibition of apoptosis. CUL9-mediated ubiquitination of BIRC5 is inhibited by the 3M complex, which consists of CUL7, CCDC8 and OBSL1 (Li et al, 2014).
Identifier: R-HSA-9622386
Species: Homo sapiens
Compartment: nucleoplasm
LEF1 binds the CEBPA promoter between 559 bp and 538 bp upstream of the transcription start and directly regulates transcription of CEBPA (Skokowa et al. 2006). LEF1 is most highly expressed in promyelocytes and a reduction of LEF1 expression is associated with neutropenia.
Elevated STAT5A protein binds LEF1, inducing LEF1 degradation and inhibiting LEF1 auto-regulation and activation of LEF1 target genes, MYC, CCND1 (cyclin D1), (BIRC5) Survivin and CEBPA (Gupta et al. 2014 ).
RUNX1 and LEF1 regulate ELANE (ELA2) mRNA expression in myeloid cells by binding to its promoter (Li et al. 2003).
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