Search results for BRD2

Showing 10 results out of 10

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Species

Types

Compartments

Reaction types

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Protein (1 results from a total of 1)

Identifier: R-HSA-8951979
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: BRD2: P25440

Complex (3 results from a total of 3)

Identifier: R-HSA-8951995
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-8951976
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-8952078
Species: Homo sapiens
Compartment: nucleoplasm

Reaction (4 results from a total of 4)

Identifier: R-HSA-8951977
Species: Homo sapiens
Compartment: nucleoplasm
RUNX3 acetylated on lysine residues K94 and K171 binds to BRD2 (bromodomain-containing protein 2). Formation of the RUNX3 complex with BRD2 is stimulated by activated KRAS (Lee et al. 2013).
Identifier: R-HSA-8952069
Species: Homo sapiens
Compartment: nucleoplasm
Histone deacetylase HDAC4, recruited to RUNX3 by CCND1 (cyclin D1), deacetylates RUNX3, leading to BRD2 dissociation (Lee et al. 2013).
Identifier: R-HSA-8952081
Species: Homo sapiens
Compartment: nucleoplasm
The CDKN2A gene promoter that regulates transcription of p14-ARF contains Runx response elements that are known to be recognized by the RUNX1:CBFB complex (Linggi et al. 2002). Based on sequence similarity between RUNX1 and RUNX3 and the fact that the complex of acetylated RUNX3 and BRD2 positively regulate p14-ARF transcription, it is possible that RUNX3 can also bind to the Runx response elements at the p14-ARF promoter (Lee et al. 2013).
Identifier: R-HSA-8952101
Species: Homo sapiens
Compartment: nucleoplasm, cytosol
Binding of the RUNX1:CBFB complex to the p14-ARF promoter at the CDKN2A locus promotes p14-ARF transcription (Linggi et al. 2002). The complex of acetylated RUNX3 and BRD2 positively regulates p14-ARF transcription, leading to activation of TP53 (p53) in response to oncogenic KRAS signaling. It is possible that RUNX3 directly binds to Runx response elements in the p14-ARF promoter that are recognized by RUNX1, although the direct association of RUNX3 with the CDKN2A gene has not been examined (Lee et al. 2013).

Set (1 results from a total of 1)

Identifier: R-HSA-8952092
Species: Homo sapiens
Compartment: nucleoplasm

Pathway (1 results from a total of 1)

Identifier: R-HSA-8951936
Species: Homo sapiens
Acetylation of RUNX3 by the histone acetyl transferase p300 (EP300) and the subsequent association of acetylated RUNX3 with BRD2 correlates with upregulation of p14-ARF transcription from the CDKN2A locus. Cyclin D1 (CCND1) negatively regulates RUNX3-facilitated induction of p14-ARF by recruiting histone deacetylase HDAC4 to RUNX3, leading to RUNX3 deacetylation (Lee et al. 2013).
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