Binding of the RUNX1:CBFB complex to the p14-ARF promoter at the CDKN2A locus promotes p14-ARF transcription (Linggi et al. 2002). The complex of acetylated RUNX3 and BRD2 positively regulates p14-ARF transcription, leading to activation of TP53 (p53) in response to oncogenic KRAS signaling. It is possible that RUNX3 directly binds to Runx response elements in the p14-ARF promoter that are recognized by RUNX1, although the direct association of RUNX3 with the CDKN2A gene has not been examined (Lee et al. 2013).