Search results for C6

Showing 12 results out of 19

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Protein (1 results from a total of 1)

C6

Identifier: R-HSA-173706
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: C6: P13671

Reaction (7 results from a total of 14)

Identifier: R-HSA-173705
Species: Homo sapiens
Compartment: extracellular region
The C5b fragment binds C6.
Identifier: R-HSA-2076419
Species: Homo sapiens
Compartment: Golgi membrane, Golgi lumen
Heparan-sulfate 6-O-sulfotransferases 1 and 2 (HS3ST1-2) (Habuchi et al. 1998, Habuchi et al. 2003 respectively) catalyze the transfer of sulfate to C6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. A third member HS3ST3 that may also mediate this reaction has been characterised in mouse (Habuchi et al. 2000) but remains uncharacterised in humans. It can be argued that this structure can now be called either heparan sulfate- or heparin-PG.
Identifier: R-HSA-77615
Species: Homo sapiens
Compartment: nucleoplasm
At the beginning of this reaction, 1 molecule of 'H2O', and 1 molecule of 'Editosome (ADAR2) complex' are present. At the end of this reaction, 1 molecule of 'NH3', and 1 molecule of 'A to I edited RNA:Editosome (ADAR2) complex' are present.

This reaction takes place in the 'nucleus' and is mediated by the 'double-stranded RNA adenosine deaminase activity' of 'ADAR2 homodimer' (Zheng et al.2017).
Identifier: R-HSA-77614
Species: Homo sapiens
Compartment: nucleoplasm
At the beginning of this reaction, 1 molecule of 'Editosome (ADAR1) complex', and 1 molecule of 'H2O' are present. At the end of this reaction, 1 molecule of 'A to I edited RNA:Editosome (ADAR1) complex', and 1 molecule of 'NH3' are present.

This reaction takes place in the 'nucleus' and is mediated by the 'double-stranded RNA adenosine deaminase activity' of 'ADAR1 homodimer ' (Zheng et al.2017).
Identifier: R-HSA-6786257
Species: Homo sapiens
Compartment: cytosol
Human dCTP pyrophosphatase 1 (DCTPP1) is a cytosolic enzyme able to hydrolyse deoxynucleoside triphosphates (dNTPs) to their corresponding nucleoside monophosphates. DCTPP1 probably plays a role in protecting DNA or RNA against the incorporation of modified nucleotide triphosphates. Based on mouse studies, Dctpp1 has strong preference for modified dCTPs, with highest activity shown towards 5-iodo-dCTP (5idCTP) (Nonaka et al. 2009). Crystal structures of mouse Dctpp1 suggest it functions as a homotetramer and requires two or three Mg2+ ions per subunit (Wu et al. 2007).
Identifier: R-HSA-3781024
Species: Homo sapiens
Compartment: cytosol
Glycogen synthase 1 (GYS1) catalyzes the incorporation of phosphoglucose into the glycogen-GYG1 molecules with which it is associated in a cytosolic glycogen granule. This reaction occurs at a low rate, yielding approximately one molecule of glucose phosphorylated at its C2, C3, or C6 positions incorporated into a growing glycogen polymer per ten thousand glucose molecules incorporated (DePaoli-Roach et al. 2015; Irimia et al. 2015; Nitschke et al. 2013; Tagliabracci et al. 2011). The function of these small amounts of phosphoglucose in normal glycogen remains to be established.
Identifier: R-HSA-3780994
Species: Homo sapiens
Compartment: cytosol
Glycogen synthase 2 (GYS2) catalyzes the incorporation of phosphoglucose into the glycogen-GYG1 molecules with which it is associated in a cytosolic glycogen granule. This reaction occurs at a low rate, yielding approximately one molecule of glucose phosphorylated at its C2, C3, or C6 positions incorporated into a growing glycogen polymer per ten thousand glucose molecules incorporated (DePaoli-Roach et al. 2015; Irimia et al. 2015; Nitschke et al. 2013; Tagliabracci et al. 2011). The function of these small amounts of phosphoglucose in normal glycogen remains to be established. This reaction has been characterized in muscle cells, where it is catalyzed by the homologous GYS1 enzyme. The occurrence of the reaction in liver, catalyzed by GYS2, can be inferred from the fact that in the absence of the enzyme EMP2A (laforin) that removes these phosphate groups, abnormally phosphorylated glycogen accumulates in both tissues (Worby et al. 2008).

Pathway (2 results from a total of 2)

Identifier: R-HSA-75102
Species: Homo sapiens
Compartment: nucleoplasm
Hydrolytic deamination of adenosine leads to inosine. Ammonia is presumed to be released during this reaction.
Identifier: R-HSA-166665
Species: Homo sapiens
After cleavage of C5, C5b undergoes conformational changes and exposes a binding site for C6. C5b6 binds C7 resulting in the exposure of membrane binding sites and incorporation into target membranes. The membrane-bound C5b-7 complex can then bind C8. C5b-8 acts as a polymerizing agent for C9. The first C9 bound to C5b-8 undergoes major structural changes enabling formation of an elongated molecule and allows binding of additional C9 molecules and insertion of C9 cylinders into the target membrane. The number of C9 molecules varies from 1-12 in the membrane, although polymers containing up to fifteen C9 molecules are also possible.

Icon (2 results from a total of 2)

C6

Species: Homo sapiens
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells
Species: Homo sapiens
The membrane attack complex (MAC) or terminal complement complex (TCC) is a structure typically formed on the surface of pathogen cell membranes as a result of the activation of the host's complement system, and as such is one of the effector proteins of the immune system. MAC forms transmembrane channels that disrupt the cell membrane of target cells, leading to cell lysis and death. Active MAC is composed of the subunits C5b, C6, C7, C8 and several C9 molecules
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