Search results for CAMKK2
Showing 20 results out of 28
Protein (4 results from a total of 4)
Identifier: R-HSA-5336483
Species:
Homo sapiens
Compartment:
nucleoplasm
Primary external reference: UniProt: CAMKK2:
Q96RR4
Identifier: R-HSA-9619231
Species:
Homo sapiens
Compartment:
cytosol
Primary external reference: UniProt: CAMKK2:
Q96RR4
Identifier: R-HSA-9618968
Species:
Homo sapiens
Compartment:
nucleoplasm
Primary external reference: UniProt: CAMKK2:
Q96RR4
Reaction (6 results from a total of 14)
Identifier: R-HSA-9619478
Species:
Homo sapiens
Compartment:
cytosol
Activated CAMKK2 (CaMKK-beta) phosphorylates the alpha subunit of AMP-activated kinase (AMPK). The CAMKK2 target site is evolutionarily conserved in two AMPK-alpha isoforms and corresponds to threonine 183 (T183) in PRKAA1 (AMPK-alpha1) and threonine 172 (T172) in PRKAA2 (AMPK-alpha2).
Identifier: R-NUL-9619413
Species:
Homo sapiens,
Rattus norvegicus
Compartment:
cytosol
Human CAMKK2 (CaMKK-beta) phosphorylates recombinant rat Camk1 (CaMKI) (Woods et al. 2005).
Identifier: R-NUL-9619177
Species:
Homo sapiens,
Rattus norvegicus
Compartment:
nucleoplasm
In the presence of recombinant calmodulin, recombinant rat Camkk2 (CaMKK-beta) phosphorylates recombinant human CAMK4 (CaMKIV) (Anderson et al. 1998). Recombinant calmodulin is assumed to be human as CALM1 seqeuence is 100% conserved between human, rat and mouse.
Identifier: R-NUL-9618897
Species:
Homo sapiens,
Rattus norvegicus
Compartment:
nucleoplasm
Recombinant human CaMKK2 (CaMKK-beta) binds recombinant rat calmodulin (Calm1, commonly labeled as CaM) (Kylarova et al. 2018). Because of uncertain CAMKK2 localization, this reaction may happen in the nucleus or in the cytosol or both.
Identifier: R-NUL-9619239
Species:
Homo sapiens,
Rattus norvegicus
Compartment:
cytosol
Recombinant human CAMKK2 (CaMKK-beta) binds recombinant rat calmodulin (Calm1, commonly labeled as CaM) (Kylarova et al. 2018). Because of uncertain CAMKK2 localization, this reaction may happen in the cytosol or in the nucleus or both.
Identifier: R-NUL-9619534
Species:
Rattus norvegicus,
Homo sapiens
Compartment:
cytosol
Recombinant rat AMPK complex, composed of AMPK-alpha1 (Prkaa1), AMPK-beta1 (Prkab1) and AMPK-gamma1 (Prkag1), phosphorylates recombinant human Tau protein on serine residues S262, S356 and S396 (Thornton et al. 2011, Mairet-Coello et al. 2013).
Complex (4 results from a total of 4)
Identifier: R-NUL-9619168
Species:
Rattus norvegicus,
Homo sapiens
Compartment:
nucleoplasm
Identifier: R-NUL-9619244
Species:
Rattus norvegicus,
Homo sapiens
Compartment:
cytosol
Identifier: R-HSA-9619404
Species:
Homo sapiens
Compartment:
cytosol
Identifier: R-NUL-9618899
Species:
Rattus norvegicus,
Homo sapiens
Compartment:
nucleoplasm
Pathway (2 results from a total of 2)
Identifier: R-HSA-9619483
Species:
Homo sapiens
Compartment:
cytosol
Activation of NMDA receptors (NMDARs) leads to activation of AMP-activated kinase (AMPK) in a CAMKK2-dependent manner. Overactivation of CAMKK2 or AMPK in neurons can lead to dendritic spine loss and is implicated in synaptotoxicity of beta-amyloids in Alzheimer's disease (Mairet-Coello et al. 2013).
Identifier: R-HSA-9619229
Species:
Homo sapiens
Activation of calcium/calmodulin-dependent kinase kinases, CaMKKs (CAMKK1 and CAMKK2), upon calcium influx through activated NMDA receptors, leads to activation of the cytosolic calcium/calmodulin kinase CaMKI (CAMK1). One of the CAMK1 targets is the RAC1 guanine nucleotide exchange factor ARHGEF7 (beta-Pix). Activation of RAC1 is involved in NMDA-receptor triggered synaptogenesis (Saneyoshi et al. 2008).
Set (4 results from a total of 4)
Identifier: R-HSA-9618961
Species:
Homo sapiens
Compartment:
nucleoplasm
Identifier: R-HSA-9618862
Species:
Homo sapiens
Compartment:
nucleoplasm
Identifier: R-HSA-9619227
Species:
Homo sapiens
Compartment:
cytosol
Identifier: R-HSA-9619354
Species:
Homo sapiens
Compartment:
cytosol
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