Search results for CAT

Showing 17 results out of 281

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Species

Types

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Reaction types

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Protein (2 results from a total of 17)

CAT

Identifier: R-HSA-51417
Species: Homo sapiens
Compartment: peroxisomal matrix
Primary external reference: UniProt: CAT: P04040

CAT

Identifier: R-HSA-6801279
Species: Homo sapiens
Compartment: ficolin-1-rich granule lumen
Primary external reference: UniProt: CAT: P04040

DNA Sequence (1 results from a total of 1)

Identifier: R-HSA-9622733
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSEMBL:ENSG00000121691

Complex (2 results from a total of 31)

Identifier: R-HSA-76028
Species: Homo sapiens
Compartment: peroxisomal matrix
Identifier: R-NUL-9622794
Species: Mus musculus, Homo sapiens
Compartment: nucleoplasm

RNA Sequence (2 results from a total of 3)

Identifier: R-HSA-9708205
Species: Homo sapiens
Compartment: cytosol
Primary external reference: RNAcentral: tRNA Met CAT: RNAcentral:URS0000145C5E_9606
Identifier: R-HSA-9708360
Species: Homo sapiens
Compartment: cytosol
Primary external reference: RNAcentral: tRNA Met CAT: RNAcentral:URS0000145C5E_9606

Reaction (2 results from a total of 154)

Identifier: R-NUL-9622751
Species: Mus musculus, Homo sapiens
Compartment: nucleoplasm
Recombinant mouse Foxo6 binds the promoter of the human CAT gene, encoding catalase (Kim et al. 2014).
Identifier: R-NUL-9622814
Species: Mus musculus, Homo sapiens
Compartment: nucleoplasm, cytosol
Transcription of the human CAT gene, encoding catalase, is directly stimulated by recombinant mouse Foxo6 (Kim et al. 2014).

Pathway (2 results from a total of 33)

Identifier: R-HSA-2022377
Species: Homo sapiens
Compartment: extracellular region, plasma membrane
Angiotensinogen, a prohormone, is synthesized and secreted mainly by the liver but also from other tissues (reviewed in Fyhrquist and Saijonmaa 2008, Cat and Touyz 2011). Renin, an aspartyl protease specific for angiotensinogen, is secreted into the bloodstream by juxtaglomerular cells of the kidney in response to a drop in blood pressure. Renin cleaves angiotensinogen to yield a decapaptide, angiotensin I (angiotensin-1, angiotensin-(1-10)). Circulating renin can also bind the membrane-localized (pro)renin receptor (ATP6AP2) which increases its catalytic activity. After cleavage of angiotensinogen to angiotensin I by renin, two C-terminal amino acid residues of angiotensin I are removed by angiotensin-converting enzyme (ACE), located on the surface of endothelial cells, to yield angiotensin II (angiotensin-2, angiotensin-(1-8)), the active peptide that causes vasoconstriction, resorption of sodium and chloride, excretion of potassium, water retention, and aldosterone secretion.
More recently other, more tissue-localized pathways leading to angiotensin II and alternative derivatives of angiotensinogen have been identified (reviewed in Kramkowski et al. 2006, Kumar et al. 2007, Fyhrquist and Saijonmaa 2008, Becari et al. 2011). Chymase, cathepsin G, and cathepsin X (cathepsin Z) can each cleave angiotensin I to yield angiotensin II. Angiotensin-converting enzyme 2 (ACE2) cleaves 1 amino acid residue from angiotensin I (angiotensin-(1-10)) to yield angiotensin-(1-9), which can be cleaved by ACE to yield angiotensin-(1-7). ACE2 can also cleave angiotensin II to yield angiotensin-(1-7). Neprilysin can cleave either angiotensin-(1-9) or angiotensin I to yield angiotensin-(1-7). Angiotensin-(1-7) binds the MAS receptor (MAS1, MAS proto-oncogene) and, interestingly, produces effects opposite to those produced by angiotensin II.
Aminopeptidase A (APA, ENPEP) cleaves angiotensin II to yield angiotensin III (angiotensin-(2-8)), which is then cleaved by aminopeptidase N (APN, ANPEP) yielding angiotensin IV (angiotensin-(3-8)). Angiotensin IV binds the AT4 receptor (AT4R, IRAP, LNPEP, oxytocinase).
Inhibitors of renin (e.g. aliskiren) and ACE (e.g. lisinopril, ramipril) are currently used to treat hypertension (reviewed in Gerc et al. 2009, Verdecchia et al. 2010, Alreja and Joseph 2011).
Identifier: R-HSA-549127
Species: Homo sapiens
The organic cation transporters comprise three SLC22 members, OCT1-3. They can transport a wide range of organic cations including weak bases. All transport by OCTs is electrogenic, sodium-independent and bidirectional. Two further organic cation transporters mediate transport of ergothioneine and carnitine (Koepsell H and Endou H, 2004).

Polymer (1 results from a total of 1)

Identifier: R-HSA-976981
Species: Homo sapiens
Compartment: extracellular region

Chemical Compound (2 results from a total of 4)

Identifier: R-ALL-5692450
Compartment: cytosol
Primary external reference: ChEBI: cation: 36916
Identifier: R-ALL-5692484
Compartment: lysosomal lumen
Primary external reference: ChEBI: cation: 36916

Set (2 results from a total of 31)

Identifier: R-ALL-426219
Compartment: extracellular region
Identifier: R-ALL-426221
Compartment: cytosol

Interactor (1 results from a total of 1)

Identifier: Q86UT8
Species: Homo sapiens
Primary external reference: UniProt: Q86UT8
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