Search results for CBX5

Showing 12 results out of 12

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Species

Types

Compartments

Reaction types

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Protein (4 results from a total of 4)

Identifier: R-HSA-994093
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: CBX5: P45973
Identifier: R-HSA-4615849
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: CBX5: P45973
Identifier: R-HSA-4615955
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: P63165
Identifier: R-HSA-4615838
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: P63165

DNA Sequence (1 results from a total of 1)

Identifier: R-HSA-9007651
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSG00000094916

Reaction (4 results from a total of 4)

Identifier: R-HSA-4615933
Species: Homo sapiens
Compartment: nucleoplasm
As inferred from mouse homologs, CBX5 (HP1 alpha) is SUMOylated at lysine-84 and other lysine residues with SUMO1. SUMOylated CBX5 associates with long non-coding transcripts in pericentric heterochromatin and SUMOylation is required for initial targeting of CBX5 to pericentric domains.
Identifier: R-HSA-9007646
Species: Homo sapiens
Compartment: nucleoplasm
Transcription of the CBX5 (HP1alpha) gene is inhibited by binding of E2F6 to the CBX5 promoter (Oberley et al. 2003).
Identifier: R-HSA-9007647
Species: Homo sapiens
Compartment: nucleoplasm
E2F6, presumably in complex with at least TFDP1 (DP-1) or TFDP2 (DP-2), binds the promoter of the CBX5 (HP1alpha) gene (Oberley et al. 2003).
Identifier: R-HSA-994106
Species: Homo sapiens
Compartment: nucleoplasm
Chromobox (CBX) genes encode members of the Heterochromatin Protein (HP) family. HP1 was discovered in Drosophila as a dominant suppressor of position-effect variegation and a major component of heterochromatin. The HP1 family is evolutionarily conserved, with members in fungi, plants and animals. Most animal species have several HP1 isoforms; humans have HP alpha, beta and gamme encoded by the genes CBX5, CBX1 and CBX3 respectively.
The HP1 amino-terminal chromodomain binds methylated lysine-9 of histone H3, causing transcriptional repression (Lachner et al. 2001). A crystal structure of human HP1 alpha in complex with H3K9(me)3 peptide is available (Amaya et al. 2008). The highly-conserved carboxy-terminal chromoshadow domain enables dimerization and also serves as a docking site for proteins involved in a wide variety of nuclear functions, from transcription to nuclear architecture.

Interactor (1 results from a total of 1)

Identifier: V9HWG0
Species: Homo sapiens
Primary external reference: UniProt: V9HWG0

Complex (2 results from a total of 2)

Identifier: R-HSA-4615966
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-9007645
Species: Homo sapiens
Compartment: nucleoplasm
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