Search results for CCL20

Showing 11 results out of 11

×

Species

Types

Compartments

Reaction types

Search properties

Species

Types

Compartments

Reaction types

Search properties

Protein (1 results from a total of 1)

Identifier: R-HSA-373097
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: CCL20: P78556

DNA Sequence (1 results from a total of 1)

Identifier: R-HSA-6785001
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSEMBL:ENSG00000115009

Reaction (3 results from a total of 3)

Identifier: R-HSA-373087
Species: Homo sapiens
Compartment: extracellular region, plasma membrane
CCR6 (Baba M et al, 1997) is expressed on inactive memory T-cells and on Th17 cells. CCR6 is down-regulated in activated T-cells. CCL20 (macrophage inflammatory protein 3-alpha, MIP 3-alpha) binds and activates CCR6 and it does not share the binding site of CCR6 with any other chemokine.
Identifier: R-HSA-3249370
Species: Homo sapiens
Compartment: cytosol, nuclear envelope, nucleoplasm
Following tyrosine phosphorylation and dimerization STAT6 translocates to the nucleus to initiate the transcription. Virus-induced STAT6 was shown to up-regulate expression of the specific gene set (Chen H et al. 2011). Among the targets are chemokines CCL2, CCL20, and CCL26, which attract cells of immune system to fight the infection.
Identifier: R-HSA-6784160
Species: Homo sapiens
Compartment: extracellular region, nucleoplasm
IL10 modulates the expression of cytokines, soluble mediators and cell surface molecules by cells of myeloid origin, with important consequences for their ability to activate and sustain immune and inflammatory responses. The effects of IL10 on cytokine production and function of human macrophages are generally similar to those on monocytes, although less pronounced (Moore et al. 2001). IL10 inhibits production of Interleukin-1 alpha (IL1A), IL1B, IL6, IL12, IL18, CSF2 (GM-CSF), CSF3 (G-CSF), CSF1 (M-CSF), TNF, LIF, PAF and itself by activated monocytes/macrophages (de Waal Malefyt et al. 1991, 1993, Fiorentino et al. 1991, D'Andrea et al. 1993, Gruber et al. 1994). The effect of IL10 on IL-1 and TNF production is particularly important as these cytokines often have synergistic effects on inflammatory processes, amplifying their effect by inducing secondary mediators such as chemokines, prostaglandins and PAF. IL10 also inhibits activated monocyte production of inducible chemokines that are involved in inflammation, namely CCL2 (MCP1), Ccl12 (MCP-5, in mice), CCL3, CCL3L1 (Mip-1alpha), CCL4 (Mip-1beta), CCL20 (Mip-3alpha), CCL19 (Mip-3beta), CCL5 (Rantes), CCL22 (MDC), CXCL8 (IL-8), CXCL10 (IP-10), CXCL2 (MIP-2) and CXCL1 (KC, Gro-alpha) (Berkman et al. 1995, Rossi et al. 1997, Marfaing-Koka et al. 1996, Kopydlowski et al. 1999). These are involved in the recruitment of monocytes, dendritic cells, neutrophils, and T cells, and affect both Th1 and Th2 responses. CXCL1 is induced by IFNgamma and attracts Th1 cells; CCL22 is induced by IL-4 and attracts Th2 cells.

IL10 inhibits expression of IL1R1 and IL-1RII (de Waal Malefyt et al. 1991, Jenkins et al. 1994, Dickensheets & Donnelly 1997).

Both transcriptional and posttranscriptional mechanisms have been implicated in the inhibitory effects of IL10 on cytokine and chemokine production (Bogdan et al. 1991, Clarke et al. 1998, Brown et al. 1996). IL10 regulates production of certain cytokines, such as CXCL1, by destabilizing mRNA via AU-rich elements in the 3'-UTR of sensitive genes (Kim et al. 1998, Kishore et al. 1999). IL-10 also enhances IL-1RA expression via inhibition of mRNA degradation (Cassatella et al. 1994).

IL10 indirectly inhibits production of prostaglandin E2 (PGE2) by downregulating PTGS2 (cyclooxygenase 2) expression (Niiro et al. 1994, 1995, Mertz et al. 1994), which also reduces expression of Matrix metalloproteinase 2 (MMP2) and MMP9, thereby modulating extracellular matrix turnover.

Complex (1 results from a total of 1)

Identifier: R-HSA-373235
Species: Homo sapiens
Compartment: plasma membrane

Set (4 results from a total of 4)

Identifier: R-HSA-6784990
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-6784987
Species: Homo sapiens
Compartment: extracellular region
Identifier: R-HSA-8937653
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-8937649
Species: Homo sapiens
Compartment: nucleoplasm

Pathway (1 results from a total of 1)

Identifier: R-HSA-3249367
Species: Homo sapiens
Signal transducer and activator of transcription 6 (STAT6) may function as a signaling molecule and as a transcription factor. The canonical activation of STAT6 in IL4 and IL13 signaling pathways is mediated by the tyrosine kinases JAK (Hebenstreit D et al. 2006). Virus-induced STAT6 activation was found to be cytokine- and JAK-independent (Chen H et al. 2011). Infection of human cells with RNA or DNA viruses resulted in an interaction of STAT6 with STING. The kinase TBK1 was shown to phosphorylate STAT6, which in turn induced STAT6 dimerization and translocation to the nucleus, leading to induction of chemokines CCL2, CCL20, and CCL26 in IFN-independent manner (Chen H et al. 2011).

RNA virus infection triggers STAT6 activation through STING, TBK1 and adaptor protein MAVS interaction (Chen H et al. 2011).

Cite Us!