Search results for CCL26

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Interactor (1 results from a total of 1)

Identifier: Q9Y258
Species: Homo sapiens
Primary external reference: UniProt: Q9Y258

Reaction (1 results from a total of 1)

Identifier: R-HSA-3249370
Species: Homo sapiens
Compartment: cytosol, nuclear envelope, nucleoplasm
Following tyrosine phosphorylation and dimerization STAT6 translocates to the nucleus to initiate the transcription. Virus-induced STAT6 was shown to up-regulate expression of the specific gene set (Chen H et al. 2011). Among the targets are chemokines CCL2, CCL20, and CCL26, which attract cells of immune system to fight the infection.

Pathway (1 results from a total of 1)

Identifier: R-HSA-3249367
Species: Homo sapiens
Signal transducer and activator of transcription 6 (STAT6) may function as a signaling molecule and as a transcription factor. The canonical activation of STAT6 in IL4 and IL13 signaling pathways is mediated by the tyrosine kinases JAK (Hebenstreit D et al. 2006). Virus-induced STAT6 activation was found to be cytokine- and JAK-independent (Chen H et al. 2011). Infection of human cells with RNA or DNA viruses resulted in an interaction of STAT6 with STING. The kinase TBK1 was shown to phosphorylate STAT6, which in turn induced STAT6 dimerization and translocation to the nucleus, leading to induction of chemokines CCL2, CCL20, and CCL26 in IFN-independent manner (Chen H et al. 2011).

RNA virus infection triggers STAT6 activation through STING, TBK1 and adaptor protein MAVS interaction (Chen H et al. 2011).

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