Search results for CDC42

Showing 21 results out of 230

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Species

Types

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Reaction types

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Protein (3 results from a total of 17)

Identifier: R-HSA-449545
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: CDC42: P60953
Identifier: R-HSA-5672086
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: CDC42: P60953
Identifier: R-HSA-442630
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: P60953

Interactor (3 results from a total of 4)

Identifier: P60953-2
Species: Homo sapiens
Primary external reference: UniProt: P60953-2
Identifier: P60953-1
Species: Homo sapiens
Primary external reference: UniProt: P60953-1
Identifier: Q9NRR8
Species: Homo sapiens
Primary external reference: UniProt: Q9NRR8

DNA Sequence (1 results from a total of 1)

Identifier: R-HSA-8950770
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: CDC42: ENSG00000070831

Reaction (3 results from a total of 128)

Identifier: R-HSA-9013159
Species: Homo sapiens
Compartment: plasma membrane, cytosol
The following guanine nucleotide exchange factors (GEFs) were shown to bind CDC42 and catalyze GDP to GTP exchange on CDC42, resulting in formation of the active CDC42:GTP complex (the high throughput study by Bagci et al. 2020 examined binding of GEFs to inactive CDC42 mutants without testing for CDC42-directed GEF activity and is cited as supporting evidence):
ARHGEF4 (Itoh et al. 2008; Anderson and Hamann 2012; Gotthardt and Ahmadian 2007; Jaiswal et al. 2013; Müller et al. 2020)
ARHGEF9 (Reid et al. 1999; Jaiswal et al. 2013; Müller et al. 2020)
ARHGEF15 (Fukushima et al. 2016; Müller et al. 2020)
DEF6 (Mavrakis et al. 2004)
DNMBP (Jaiswal et al. 2013; Müller et al. 2020; supported by Bagci et al. 2020)
FGD1 (Olson et al. 1996; Müller et al. 2020)
FGD2 (Huber et al. 2008; Müller et al. 2020)
FGD3 (Hayakawa et al. 2008; Müller et al. 2020)
FGD4 (Umikawa et al. 1999; Müller et al. 2020)
GNA13 (Yan et al. 2015)
MCF2 (Ueda et al. 2004; Jaiswal et al. 2013; Müller et al. 2020)
MCF2L (Ueda et al. 2004; Whitehead et al. 1999; Jaiswal et al. 2013; Müller et al. 2020; supported by Bagci et al. 2020)
PLEKHG1 (Abiko et al. 2015; Müller et al. 2020; supported by Bagci et al. 2020)
PLEKHG3 (Nguyen et al. 2016; Müller et al. 2020; supported by Bagci et al. 2020)
PLEKHG4 (Gupta et al. 2013; Müller et al. 2020; supported by Bagci et al. 2020)
PLEKHG4B (Müller et al. 2020)
SPATA13 (Hamann et al. 2007; Kawasaki et al. 2007; Bristow et al. 2009; Müller et al. 2020)

The following GEFs; annotated as CDC42 candidate GEFs; were shown to activate CDC42 by some; but not all studies (the high throughput study by Bagci et al. 2020 examined binding of GEFs to inactive CDC42 mutants without testing for CDC42-directed GEF activity and is cited as supporting evidence):
ABR (Chuang et al. 1995: CDC42-directed GEF activity; Müller et al. 2020: no CDC42-directed GEF activity)
ARHGEF5 (Xie et al. 2005: CDC42 directed GEF activity; Müller et al. 2020: no CDC42 directed GEF activity; Bagci et al. 2020: no binding to inactive CDC42)
ARHGEF6 (Manser et al. 1998, Ramakers et al. 2012: CDC42-directed GEF activity; Müller et al. 2020: no CDC42 directed GEF activity)
ARHGEF10 (Müller et al. 2020: CDC42 directed GEF activity; Mohl et al. 2006: no CDC42-directed GEF activity)
ARHGEF11 (Bagci et al. 2020: binding to inactive CDC42; Rümenapp et al. 1999, Jaiswal et al. 2011, Jaiswal et al. 2013, Müller et al. 2020: no CDC42 directed GEF activity)
ARHGEF12 (Bagci et al. 2020: binding to inactive CDC42; Reuther et al. 2001, Jaiswal et al. 2011, Jaiswal et al. 2013, Müller et al. 2020: no CDC42 directed GEF activity)
ARHGEF16 (Bagci et al. 2020: binding to inactive CDC42; Hiramoto Yamaki et al. 2010, Müller et al. 2020: no CDC42 directed GEF activity)
ARHGEF19 (Wang et al. 2004: CDC42-directed GEF activity; Müller et al. 2020: no CDC42-directed GEF activity)
ARHGEF25 (Guo et al. 2003: CDC42-directed GEF activity; Müller et al. 2020: no CDC42-directed GEF activity)
ARHGEF26 (Müller et al. 2020: CDC42 directed GEF activity; Bagci et al. 2020: binding to inactive CDC42; Ellerbroek et al. 2004: no CDC42 directed GEF activity)
BCR (Chuang et al. 1995; Korus et al. 2002: CDC42 directed GEF activity; Müller et al. 2020: no CDC42 directed GEF activity; Bagci et al. 2020: no binding to inactive CDC42)
DOCK6 (Miyamoto et al. 2007: CDC42 directed GEF activity; Müller et al. 2020: no CDC42 directed GEF activity; Bagci et al. 2020: no binding to inactive CDC42)
DOCK7 (Kukimoto Niino et al. 2019, Wilkes et al. 2014, Zhou et al. 2013, Yamauchi et al. 2008: CDC42-directed GEF activity; Müller et al. 2020: no CDC42-directed GEF activity; Bagci et al. 2020: no binding to inactive CDC42)
DOCK8 (Harada et al. 2012, Martins et al. 2016, Xu et al. 2017: CDC42-directed GEF activity; Bagci et al. 2020: binding to inactive CDC42; Müller et al. 2020: no CDC42-directed GEF activity)
DOCK9 (Cote and Vuori 2002, Kulkarni et al. 2011: CDC42-directed GEF activity; Bagci et al. 2020: binding to inactive CDC42; Müller et al. 2020: no CDC42-directed GEF activity)
DOCK10 (Gadea et al. 2008, Ruiz Lafuente et al. 2015: CDC42-directed GEF activity; Bagci et al. 2020: binding to inactive CDC42; Müller et al. 2020: no CDC42-directed GEF activity)
DOCK11 (Lin et al. 2006: CDC42-directed GEF activity; Bagci et al. 2020: binding to inactive CDC42; Müller et al. 2020: no CDC42-directed GEF activity)
ECT2 (Tatsumoto et al. 1999, Fortin et al. 2012: CDC42 directed GEF activity; Müller et al. 2020: no CDC42 directed GEF activity; Bagci et al. 2020: no binding to inactive CDC42)
FARP1 (Amado Azevedo et al. 2017: CDC42 directed GEF activity; Müller et al. 2020: no CDC42 directed GEF activity; Bagci et al. 2020: no binding to inactive CDC42)
ITSN1 (Hussain et al. 2001, Jaiswal et al. 2013: CDC42-directed GEF activity; Müller et al. 2020: no CDC42-directed GEF activity)
NGEF (Zhang et al. 2007: CDC42 directed GEF activity; Müller et al. 2020: no CDC42 directed GEF activity; Bagci et al. 2020: no binding to inactive CDC42)
PLEKHG2 (Ueda et al. 2008: CDC42-directed GEF activity; Bagci et al. 2020: binding to inactive CDC42; Müller et al. 2020: no CDC42-directed GEF activity)
PREX1 (Jaiswal et al. 2013: CDC42 directed GEF activity; Marei et al. 2016, Müller et al. 2020: no CDC42 directed GEF activity)
PREX2 (Müller et al. 2020: CDC42-directed GEF activity; Joseph and Norris 2005: no CDC42-directed GEF activity)
RASGRF2 (Müller et al. 2020: CDC42-directed GEF activity; Calvo et al. 2011: no CDC42-directed GEF activity)
TIAM1 (Michiels et al. 1995: CDC42 directed GEF activity; Itoh et al. 2008, Jaiswal et al. 2013, Müller et al. 2020: no CDC42 directed GEF activity; Bagci et al. 2020: no binding to inactive CDC42)
TRIO (Peurois et al. 2017, Fortin et al. 2012, Jaiswal et al. 2013: CDC42 directed GEF activity, the presence of membrane may be necessary; Debant et al. 1996: no CDC42-directed GEF activity of either the N-terminal GEF1 domain or the C-terminal GEF2 domain of TRIO in vitro; Müller et al. 2020: no CDC42 directed GEF activity of the full-length TRIO; Bagci et al. 2020: no binding of full-length TRIO to inactive CDC42)
VAV2 (Itoh et al. 2008, Aoki et al. 2005, Heo et al. 2005, Jaiswal et al. 2013: CDC42-directed GEF activity; Bagci et al. 2020: binding to inactive CDC42; Müller et al. 2020: no CDC42 directed GEF activity)
VAV3 (Sachdev et al. 2002; Aoki et al. 2005: CDC42 directed GEF activity; Movilla and Bustelo 1999, Müller et al. 2020: no CDC42 directed GEF activity)

The following GEFs do not act on CDC42 or were shown to not bind to inactive CDC42 mutant in the high throughput screen by Bagci et al. 2020):
AKAP13 (Zheng et al. 1995; Müller et al. 2020; Bagci et al. 2020: no binding to inactive CDC42)
ALS2 (Müller et al. 2020)
ARHGEF1 (Hart et al. 1996; Jaiswal et al. 2013; Jaiswal et al. 2011; Müller et al. 2020; Bagci et al. 2020: no binding to inactive CDC42)
ARHGEF2 (Krendel et al. 2002; Müller et al. 2020; Bagci et al. 2020: no binding to inactive CDC42)
ARHGEF3 (Arthur et al. 2002; Müller et al. 2020)
ARHGEF7 (Manser et al. 1998; Müller et al. 2020; Bagci et al. 2020: no binding to inactive CDC42)
ARHGEF10L (Winkler et al. 2005; Müller et al. 2020)
ARHGEF17 (Rümenapp et al. 2002; Müller et al. 2020; Bagci et al. 2020: no binding to inactive CDC42)
ARHGEF18 (Niu et al. 2003; Blomquist et al. 2000; Müller et al. 2020)
ARHGEF28 (van Horck et al. 2001; Jaiswal et al. 2011; Jaiswal et al. 2013; Müller et al. 2020)
ARHGEF39 (Müller et al. 2020)
ARHGEF40 (Curtis et al. 2004; Müller et al. 2020; Bagci et al. 2020: no binding to inactive CDC42)
DOCK1 (Cote and Vuori 2002; Müller et al. 2020; Bagci et al. 2020: no binding to inactive CDC42)
DOCK2 (Kulkarni et al. 2011; Kwofie and Skowronski 2008; Müller et al. 2020)
DOCK3 (Kwofie and Skowronski 2008; Müller et al. 2020)
DOCK4 (Kwofie and Skowronski 2008; Abraham et al. 2015; Müller et al. 2020; Bagci et al. 2020: no binding to inactive CDC42)
DOCK5 (Vives et al. 2011; Müller et al. 2020; Bagci et al. 2020: no binding to inactive CDC42)
ECT2L (Müller et al. 2020)
FARP2 (Kubo et al. 2002; Müller et al. 2020)
FGD5 (Müller et al. 2020)
FGD6 (Müller et al. 2020)
ITSN2 (Müller et al. 2020)
KALRN (Penzes et al. 2001; Müller et al. 2020)
MCF2L2 (Müller et al. 2020)
NET1 (Alberts and Treisman 1998; Müller et al. 2020)
OBSCN (Ford Speelman et al. 2009)
PLEKHG5 (De Toledo et al. 2001; Müller et al. 2020)
PLEKHG6 (Müller et al. 2020)
PLEKHG7 (Müller et al. 2020)
RASGRF1 (Müller et al. 2020)
SOS1 (Nimnual et al. 1998; Müller et al. 2020)
SOS2 (Nimnual et al. 1998; Müller et al. 2020)
SWAP70 (Bagci et al. 2020: no binding to inactive CDC42)
TIAM2 (Müller et al. 2020)
VAV1 (Aghazadeh et al. 2000; Müller et al. 2020)
Identifier: R-HSA-9013158
Species: Homo sapiens
Compartment: plasma membrane, cytosol
The following GDP dissociation inhibitors (GDIs) bind to CDC42 and inhibit its activation:
ARHGDIA (Gupta et al. 2013; Murphy et al. 2001)
ARHGDIG (Adra et al. 1997)
ARHGDIB (Adra et al. 1993)
CAV1 (Nevins and Thurmond 2006)
Identifier: R-HSA-418850
Species: Homo sapiens
Compartment: cytosol, plasma membrane
RhoGEF complexed with Netrin-1-DCC induces guanine nucleotide exchange by Cdc42, activating it. Activated Cdc42 activates N-WASP, which promotes the nucleation of F-actin via the Arp2/3 complex. Netrin-1, via DCC, influences cellular motility by regulating actin-based membrane extension through the activation of Cdc42.

Set (3 results from a total of 11)

Identifier: R-HSA-1012988
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-9013234
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-9013227
Species: Homo sapiens
Compartment: cytosol, plasma membrane

Complex (3 results from a total of 42)

Identifier: R-HSA-1012969
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-8964618
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-9014577
Species: Homo sapiens
Compartment: plasma membrane

Pathway (3 results from a total of 25)

Identifier: R-HSA-9013148
Species: Homo sapiens
This pathway catalogues CDC42 guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs), GDP dissociation inhibitors (GDIs) and CDC42 effectors. CDC42 is one of the three best characterized RHO GTPases, the other two being RHOA and RAC1. By regulating the cytoskeleton, CDC42 regulates cell polarity across different species, from yeast to humans (Pichaud et al. 2019, Woods and Lew 2019). CDC42 is an essential regulator of polarized morphogenesis in epithelial cells, where it coordinates formation of the apical membrane and lumen formation, as well as junction maturation (Pichaud et al. 2019). CDC42 plays a role in cell-to-cell adhesion and cell cycle regulation (Xiao et al. 2018). CDC42 takes part in the regulation of membrane trafficking. Dysfunction of several CDC42-specific GEFs has been shown to impair intracellular trafficking (Egorov and Polishchuk 2017). CDC42 participates in insulin synthesis and secretion and contributes to the pathogenesis of insulin resistance and diabetic nephropathy (Huang et al. 2019). CDC42 is often dysregulated in cancer because a number of GEFs and GEF activators that act upstream of RAC1 and CDC42 are known oncogenes (Aguilar et al. 2017; Maldonado et al. 2018; Zhang et al. 2019; Maldonado et al. 2020). CDC4 promotes cancer cell proliferation, survival, invasion, migration and metastasis (Xiao et al. 2018), especially under hyperglycemia (Huang et al. 2019).
Identifier: R-HSA-8964616
Species: Homo sapiens
Compartment: plasma membrane, cytosol
G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins (G-proteins) that have alpha, beta and gamma subunits. Upon activation, the alpha subunit of G-proteins dissociates from beta-gamma and the both are then free to regulate downstream effectors. Serine/threonine-protein kinase PAK 1 binds with Rho guanine nucleotide exchange factor 6 (ARHGEF6, PIX-Alpha) in the cytosol and is subsequently translocated by the G-protein beta-gamma complex to the plasma membrane. Here, ARHGEF6 activates Cell division control protein 42 homolog (CDC42) by acting as a GEF. Once active, CDC42 can facilitate the activation of PAK1. CDC42 is known to be involved in epithelial cell polarization processes.
Identifier: R-HSA-428543
Species: Homo sapiens
Compartment: plasma membrane
Rho family GTPases, including RAC1, RHOA, and CDC42, are ideal candidates to regulate aspects of cytoskeletal dynamics downstream of axon guidance receptors. Biochemical and genetic studies have revealed an important role for CDC42 and RAC1 in ROBO repulsion. ROBO controls the activity of Rho GTPases by interacting with a family of SLIT/ROBO-specific GAPs (SrGAPs) and Vilse/CrossGAP. SrGAPs inactivate CDC42 and Vilse/CrossGAP specifically inactivates RAC1.
It was recently implicated that SRGAP3 may inactivate RAC1 downstream of SLIT1-activated ROBO2, which promotes neurite outgrowth in mammalian dorsal root ganglion (DRG) neurons (Zhang et al. 2014).

Icon (2 results from a total of 2)

Species: Homo sapiens
Curator: Steve Jupe
Designer: Cristoffer Sevilla
CDC42 icon
Cell division control protein 42 homolog

ACK

Species: Homo sapiens
Activated CDC42 kinase 1
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