Search results for CDC42

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Reaction (3 results from a total of 130)

Identifier: R-HSA-8854897
Species: Homo sapiens
Compartment: cytosol, extracellular region, plasma membrane
Grb-associated binder (GAB) proteins are a family of docking proteins that transduce cellular signals between receptors and intracellular downstream effectors (Ding et al. 2015). When phosphorylated by protein-tyrosine kinases, GABs can recruit several Src homology-2 (SH2) domain-containing proteins, including Tyrosine-protein phosphatase non-receptor type 11 (PTPN11, SHP2), the p85 subunit of phosphoinositide-3 kinase (p85-PI3K), phospholipase C-gamma 1 (PLCG1), CRK and GAB-associated Cdc42/Rac GTPase-activating protein (ARHGAP32, GC-GAP). These interactions lead to various downstream signals involved in cell growth, differentiation, migration and apoptosis.

GDNF stimulation of neuronal cells induces the assembly of a large protein complex containing RET, GRB2 and tyrosine-phosphorylated SHC1, p85-PI3K, GAB2 (GAB1 in Hayashi et al. 2000) and PTPN11 (Besset et al. 2000). GAB1 was found in complexes with GRB2 only after GDNF treatment (Hayashi et al. 2000). This contrasts with reports that GAB2 constitutively associates with GRB2 (Gu et al. 1998).

The likely order of recruitment to RET is SHC1, GRB2, GAB1/2, p85-PI3K, similar to the signaling mechanism of the Interleukin-3 receptor (Gu et al. 2000) and many others (Adams et al. 2012, Ding et al. 2015). As the order of RET complex formation is not firmly established, GAB binding is shown as an uncertain event.
Identifier: R-HSA-9018794
Species: Homo sapiens
Compartment: plasma membrane, cytosol
In its active GTP bound form, RHOV activates the following effectors:
PAK1 (Weisz Hubsman et al. 2007; Bagci et al. 2020)
PAK2 (Aronheim et al. 1998; Bagci et al. 2020)
PAK6 (Shepelev and Korobko 2012)
The functional consequences of the interaction have only been established for RHOV and PAK1 (Weisz Hubsman et a. 2007).

The following candidate RHOV effectors were identified in the high throughput screens by Aspenström et al. 2004 and Bagci et al. 2020; the biological roles of these interactions have not been characterized:
ARHGEF7 (Bagci et al. 2020)
CCP110 (Bagci et al. 2020)
CDC42 (Bagci et al. 2020)
CEP97 (Bagci et al. 2020)
CLTC (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
DLG5 (Bagci et al. 2020)
DST (Bagci et al. 2020)
EPHA2 (Bagci et al. 2020)
GIT1 (Bagci et al. 2020)
GIT2 (Bagci et al. 2020)
IQGAP1 (Bagci et al. 2020)
MAP3K11 (Aspenström et al. 2004)
MAP3K21 (Bagci et al. 2020)
MYH11 (Bagci et al. 2020)
MYL12B (Bagci et al. 2020)
MYO6 (Bagci et al. 2020)
NCK1 (Bagci et al. 2020)
NCK2 (Bagci et al. 2020);
PAK4 (Aspenström et al. 2004; Bagci et al. 2020: weak interaction)
PARD6A (Aspenström et al. 2004)
PARD6B (Bagci et al. 2020: weak interaction)
PEAK1 (Bagci et al. 2020)
SH3RF1 (Bagci et al. 2020)
SPTAN1 (Bagci et al. 2020)
SPTBN1 (Bagci et al. 2020)
TPM3 (Bagci et al. 2020)
TPM4 (Bagci et al. 2020)
TXNL1 (Bagci et al. 2020)
USP9X (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
WASL (Aspenström et al. 2004; Bagci et al. 2020)
WDR6 (Bagci et al. 2020)
ZNF512B (Bagci et al. 2020)

Active RHOV does not bind the following putative effector proteins which do bind active RHOU:
HGS (Bagci et al. 2020)
PAK3 (Bagci et al. 2020)
STAM (Bagci et al. 2020)
STAM2 (Bagci et al. 2020)
WWP2 (Bagci et al. 2020)
Identifier: R-HSA-9018808
Species: Homo sapiens
Compartment: plasma membrane, cytosol
In its active form, plasma membrane associated RAC3 binds to the following effectors:
NOX1 complex (Miyano et al. 2009)
NOX2 complex (Miyano et al. 2009)
NOX3 complex (Miyano et al. 2009)
PAK2 (Bagci et al. 2020; activation of PAK2 downstream of RAC3 was demonstrated by Mira et al. 2000, but direct binding was not tested in the study)
WAVE1 complex, through direct interaction with WASF1 (Bagci et al. 2020) and CYFIP1 (Bagci et al. 2020)
WAVE2 complex, through direct interaction with WASF2 (Bagci et al. 2020) and CYFIP1 (Bagci et al. 2020)

The following proteins are annotated as candidate RAC3 effectors because their interactions with RAC3 have not been sufficiently characterized:
ABI1 (Bagci et al. 2020)
ABI2 (Bagci et al. 2020)
ABL2 (Bagci et al. 2020)
AMIGO2 (Bagci et al. 2020)
BAIAP2 (Bagci et al. 2020)
BAIAP2L1 (Bagci et al. 2020)
BRK1 (Bagci et al. 2020)
CAV1 (Bagci et al. 2020)
CDC42 (Bagci et al. 2020)
CDC42EP1 (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
DIAPH3 (Bagci et al. 2020)
DSG2 (Bagci et al. 2020)
EPHA2 (Bagci et al. 2020)
ERBIN (Bagci et al. 2020)
FERMT2 (Bagci et al. 2020)
GIT1 (Bagci et al. 2020)
GIT2 (Bagci et al. 2020)
IL32 (Bagci et al. 2020)
ITGB1 (Bagci et al. 2020)
JAG1 (Bagci et al. 2020)
KIAA0355 (Bagci et al. 2020)
LAMTOR1 (Bagci et al. 2020)
MCAM (Bagci et al. 2020)
MPP7 (Bagci et al. 2020)
NCKAP1 (Bagci et al. 2020)
NHS (Bagci et al. 2020)
PAK1 (Mira et al. 2000: RAC3 induces PAK1 activation but direct interaction has not been tested)
PAK4 (Bagci et al. 2020)
RAB7A (Bagci et al. 2020)
RAPGEF1 (Bagci et al. 2020)
SLC1A5 (Bagci et al. 2020)
SLITRK3 (Bagci et al. 2020)
SLITRK5 (Bagci et al. 2020)
SNAP23 (Bagci et al. 2020)
STBD1 (Bagci et al. 2020)
SWAP70 (Bagci et al. 2020)
TAOK3 (Bagci et al. 2020)
TFRC (Bagci et al. 2020)
TMPO (Bagci et al. 2020)
VAMP3 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)

Active RAC3 does not bind to the following established or putative RAC effectors:
ANKLE2 (Bagci et al. 2020)
ARAP2 (Bagci et al. 2020)
ARFGAP3 (Bagci et al. 2020)
ARMCX3 (Bagci et al. 2020)
CDC42EP4 (Bagci et al. 2020)
DOCK1 (Bagci et al. 2020)
DOCK5 (Bagci et al. 2020)
ELMO2 (Bagci et al. 2020)
HSPE1 (Bagci et al. 2020)
LETM1 (Bagci et al. 2020)
NDUFA5 (Bagci et al. 2020)
NDUFS3 (Bagci et al. 2020)
PLEKHG3 (Bagci et al. 2020)
PLEKHG4 (Bagci et al. 2020)
SHTM2 (Bagci et al. 2020)
STX5 (Bagci et al. 2020)
VAPB (Bagci et al. 2020)
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