Search results for CECR1

Showing 7 results out of 7

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Species

Types

Compartments

Reaction types

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Protein (2 results from a total of 2)

Identifier: R-HSA-6798756
Species: Homo sapiens
Compartment: azurophil granule lumen
Primary external reference: UniProt: ADA2: Q9NZK5
Identifier: R-HSA-5693339
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: ADA2: Q9NZK5

Complex (2 results from a total of 2)

Identifier: R-HSA-5693328
Species: Homo sapiens
Compartment: extracellular region
Identifier: R-HSA-5693363
Species: Homo sapiens
Compartment: extracellular region

Reaction (3 results from a total of 3)

Identifier: R-HSA-5693346
Species: Homo sapiens
Compartment: extracellular region
Adenosine deaminase (CECR1, ADA2) degrades extracellular adenosine (Ade-Rib), a signaling molecule that controls a variety of cellular responses (Zavialov & Engstrom 2005). Extracellular adenosine can bind and activate four adenosine receptors (ADRs), triggering multiple intracellular processes leading to either cell activation or in suppression of cell function and cell death. ADA2 (and ADA1) decrease the local concentration of adenosine by catalysing the deamination of adenosine to inosine (Ino). ADA2 is dimeric, binding one Zn2+ ion per subunit (Zavialov et al. 2010).
Identifier: R-HSA-418925
Species: Homo sapiens
Compartment: extracellular region, plasma membrane
Adenosine receptors A2a and A2b (ADORA2A and ADORA2B) bind extracellular adenosine (Ado-Rib) and are believed to play a role in regulating myocardial oxygen consumption and coronary blood flow (Peterfreund 1996). The A2A receptor is responsible for regulating myocardial blood flow by vasodilation of the coronary arteries, which increases blood flow to the myocardium, but may lead to hypotension. Just as in A1 receptors, this normally serves as a protective mechanism. A2B receptor work (Pierce KD et al, 1992) has lagged behind research in the other adenosine receptors.
Both ADORA receptors mediate their actions by coupling with the G protein alpha s subunit which activates adenylyl cyclase and increases intracellular cAMP concentrations. In surfactant physiology, the receptor:adenosine complex positively regulates surfactant export from lamellar bodies. (Cooper JA et al, 1995; Linden J et al, 1999). Adenosine deaminase (CECR1, ADA2) degrades extracellular adenosine (Ade-Rib), reducing or neutralising the positive regulatory effect of adenosine in surfactant export.
Identifier: R-HSA-9660829
Species: Homo sapiens
Compartment: extracellular region, plasma membrane
Adenosine receptors A2a and A2b (ADORA2A and ADORA2B) bind extracellular adenosine (Ado-Rib) and are believed to play a role in regulating myocardial oxygen consumption and coronary blood flow (Peterfreund 1996). The A2A receptor is responsible for regulating myocardial blood flow by vasodilation of the coronary arteries, which increases blood flow to the myocardium, but may lead to hypotension. Just as in A1 receptors, this normally serves as a protective mechanism. A2B receptor work (Pierce KD et al, 1992) has lagged behind research in the other adenosine receptors.
Both ADORA receptors mediate their actions by coupling with the G protein alpha s subunit which activates adenylyl cyclase and increases intracellular cAMP concentrations. In surfactant physiology, the receptor:adenosine complex positively regulates surfactant export from lamellar bodies. (Cooper JA et al, 1995; Linden J et al, 1999). Adenosine deaminase (CECR1, ADA2) degrades extracellular adenosine (Ade-Rib), reducing or neutralising the positive regulatory effect of adenosine in surfactant export.
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