Search results for CHP1

Showing 4 results out of 4

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Species

Types

Compartments

Reaction types

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Species

Types

Compartments

Reaction types

Search properties

Protein (1 results from a total of 1)

Identifier: R-HSA-5333747
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: CHP1: Q99653

Complex (1 results from a total of 1)

Identifier: R-HSA-5333752
Species: Homo sapiens
Compartment: plasma membrane

Interactor (1 results from a total of 1)

Identifier: Q9UHD1
Species: Homo sapiens
Primary external reference: UniProt: Q9UHD1

Reaction (1 results from a total of 1)

Identifier: R-HSA-2160884
Species: Homo sapiens
Compartment: plasma membrane
Hyaluronidases are only active in acidic environments. HYAL2 can interact with the Na+-H+ exchanger (SLC9A1, NHE1) which can create an acidic microenvironment in the caveolae. Extracellular Na+ ions are exchanged for protons which creates the acidic conditions required for the activity of HYAL2 (Bourguignon et al. 2004). The interaction of calcineurin homologous protein 1 (CHP1) with SLC9A1 is essential for the maintenance of, or increasing, the pH sensitivity of SLC9A1 thus CHP1 can regulate SLC9A1 activity (Lin & Barber 1996, Pang et al. 2004, Mishima et al. 2007). CHP1 depletion in Xenopus oocytes results in a dramatic reduction (>90%) in the Na+-H+ exchange activity of SLC9A1 (Pang et al. 2001).
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