Search results for CHRM2

Showing 9 results out of 9

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Species

Types

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Protein (2 results from a total of 2)

Identifier: R-HSA-390654
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: CHRM2: P08172
Identifier: R-HSA-8869085
Species: Homo sapiens
Compartment: clathrin-coated endocytic vesicle membrane
Primary external reference: UniProt: CHRM2: P08172

Reaction (3 results from a total of 3)

Identifier: R-HSA-9704297
Species: Homo sapiens
Compartment: plasma membrane, extracellular region
The M2 muscarinic receptors (CHRM2) are expressed mainly in the heart but also in many other tissues. Here, they act to slow the heart rate down by slowing the speed of depolarization. CHRM2 act via a Gi signalling pathway, which causes a decrease in intracellular cAMP leading to inhibitory-type effects (Caulfield & Birdsall 1998). Inhibition of CHRM2 for example by atropine or hyoscyamine will cause a rise in heart rate (Bagshaw et al. 1970).
Identifier: R-HSA-390673
Species: Homo sapiens
Compartment: extracellular region, plasma membrane
M2 muscarinic receptors (Peralta EG et al, 1987) are located in the heart, where they act to slow the heart rate down to normal sinus rhythm after stimulatory actions of the sympathetic nervous system. This is achieved by slowing the speed of depolarization. M4 muscarinic receptors are expressed in the CNS (Peralta EG et al, 1987). Both receptors act via Gi proteins, causing a decrease in cAMP in the cell and generally leading to inhibitory-type effects (Bräuner-Osborne H and Brann MR, 1996).
Identifier: R-HSA-8866269
Species: Homo sapiens
Compartment: plasma membrane
Beta arrestins 1 and 2 are required for the endocytosis and downregulation of numerous GPCRs including ADRB2, CHRM2, FZD, C5aR and many others (Ferguson et al, 1995; Goodman et al, 1995; Chen et al, 2003; Gurevich et al, 1995; Braun et al, 2003; reviewed in Kovacs et al, 2009; Traub and Bonifacino, 2013). Beta-arrestin mediated downregulation of GPCRs is modulated by receptor phosphorylation status (see for instance Fessart et al, 2007; Braun et al, 2003; reviewed in Gurevich and Gurevich, 2006). In addition to recognizing GPCR cargo, beta-arrestins also bind directly to the AP-2 complex, thus mediating the recruitment of cargo into nascent clathrin coated vesicles (Edeling et al, 2006; Schmid et al, 2006; reviewed in Traub and Bonifacino, 2013; Kang et al, 2014). A recent study has shown that in addition to mediating GPCR endocytosis, beta-arrestin2 can be recruited to CCPs after dissociation from ADRB2 to promote MAPK signaling, highlighting a role for CCPs as signaling microdomains (Eichel et al, 2016).

Set (2 results from a total of 2)

Identifier: R-ALL-9704261
Compartment: extracellular region
Identifier: R-HSA-390686
Species: Homo sapiens
Compartment: plasma membrane

Complex (2 results from a total of 2)

Identifier: R-HSA-9704275
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-390685
Species: Homo sapiens
Compartment: plasma membrane
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