Search results for CLEC4C

Showing 8 results out of 8

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Protein (4 results from a total of 4)

Identifier: R-HSA-6800186
Species: Homo sapiens
Compartment: tertiary granule membrane
Primary external reference: UniProt: CLEC4C: Q8WTT0
Identifier: R-HSA-2130705
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: CLEC4C: Q8WTT0
Identifier: R-HSA-6801022
Species: Homo sapiens
Compartment: secretory granule membrane
Primary external reference: UniProt: CLEC4C: Q8WTT0
Identifier: R-HSA-6800915
Species: Homo sapiens
Compartment: ficolin-1-rich granule membrane
Primary external reference: UniProt: CLEC4C: Q8WTT0

Reaction (1 results from a total of 1)

Identifier: R-HSA-5621371
Species: Homo sapiens
Compartment: plasma membrane, viral envelope
CLEC4C (C-type lectin domain family 4 member C/Blood dendritic cell antigen 2 (BDCA2)) is a member of the Dectin-2 family expressed exclusively on plasmacytoid dendritic cells (pDCs). CLEC4C is capable of binding certain CD14+ monocytes, monocyte-derived DCs and several tumour cell lines by recognising sugars asialo-galactosyl-oligosaccharides with terminal beta1-4- and beta1-3-galactose residues. CLEC4C has also been shown to bind the HIV-1 envelope glycoprotein gp120 and hepatitis C virus (HCV) glycoprotein E2 (Kerscher et al. 2013, Riboldi et al. 2011, Florentin et al. 2011).
CLEC4C lacks signalling motif in its cytoplasmic tail and associates with transmembrane adapter FCERG (High affinity immunoglobulin epsilon receptor subunit gamma) to induce intracellular signal transduction in a B-cell receptor (BCR)-like fashion employing SYK to regulate the immune functions of pDCs. The FCERG-SYK signalling pathway interferes with TLR9-induced activation of pDC, inhibiting type I IFN secretion (Cao et al. 2007, Dzionek et al. 2001, Rock et al. 2007, Riboldi et al. 2011).

Complex (2 results from a total of 2)

Identifier: R-HSA-5621153
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-5621155
Species: Homo sapiens
Compartment: plasma membrane

Pathway (1 results from a total of 1)

Identifier: R-HSA-5621480
Species: Homo sapiens
Compartment: plasma membrane
Dendritic cell-associated C-type lectin-2 (Dectin-2) family of C-type lectin receptors (CLRs) includes Dectin-2 (CLEC6A), blood dendritic antigen 2 (BDCA2/CLEC4C), macrophage C-type lectin (MCL/CLEC4D), Dendritic cell immunoreceptor (DCIR/CLEC4A) and macrophage inducible C-type lectin (Mincle/CLEC4E). These receptors possesses a single extracellular conserved C-type lectin domain (CTLD) with a short cytoplasmic tail that induces intracellular signalling indirectly by binding with the FCERG (High affinity immunoglobulin epsilon receptor subunit gamma) except for DCIR that has a longer cytoplasmic tail with an integral inhibitory signalling motif (Graham & Brown. 2009, Kerschera et al. 2013). CLEC6A (Dectin-2) binds to high mannose containing pathogen-associated molecular patterns (PAMPs) expressed by fungal hyphae, and CLEC4E (mincle) binds to alpha-mannaosyl PAMPs on fungal, mycobacterial and necrotic cell ligands. Both signaling pathways lead to Toll-like receptor (TLR)-independent production of cytokines such as tumor necrosis factor (TNF) and interleukin 6 (IL6). Similarities with Dectin-1 (CLC7A) signaling pathway suggests that both these CLRs couple SYK activation to NF-kB activation using a complex involving CARD9, BCL10 and MALT1 (Geijtenbeek & Gringhuis 2009).
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