Search results for COLEC12

Showing 13 results out of 13

×

Species

Types

Compartments

Reaction types

Search properties

Species

Types

Compartments

Reaction types

Search properties

Protein (2 results from a total of 2)

Identifier: R-HSA-2187209
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: COLEC12: Q5KU26
Identifier: R-HSA-2981044
Species: Homo sapiens
Compartment: endocytic vesicle membrane
Primary external reference: UniProt: COLEC12: Q5KU26

Set (3 results from a total of 3)

Identifier: R-HSA-2187235
Species: Homo sapiens
Compartment: extracellular region
Identifier: R-HSA-2981036
Species: Homo sapiens
Compartment: endocytic vesicle lumen
Identifier: R-HSA-8959654
Species: Homo sapiens
Compartment: plasma membrane

Complex (5 results from a total of 5)

Identifier: R-HSA-2187243
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-2981045
Species: Homo sapiens
Compartment: endocytic vesicle membrane
Identifier: R-HSA-2187245
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-2981043
Species: Homo sapiens
Compartment: endocytic vesicle membrane
Identifier: R-HSA-8862077
Species: Homo sapiens
Compartment: plasma membrane

Reaction (3 results from a total of 3)

Identifier: R-HSA-2187261
Species: Homo sapiens
Compartment: plasma membrane, extracellular region
COLEC12 (SCARA4) binds beta-glucan (Jang et al. 2009), N-acetylgalactosamine (Yoshida et al. 2003), oxidized LDL (Ohtani et al. 2001), and double-stranded RNA (DeWitte-Orr et al. 2010). COLEC12 is expressed on endothelial cells
Identifier: R-HSA-2981040
Species: Homo sapiens
Compartment: endocytic vesicle membrane, plasma membrane
COLEC12 (CL-P1, SCARA4, SRCL, NSR2) bound to yeast or bacteria is phagocytosed (Jang et al. 2009, Ohtani et al. 2012). Endocytosis of other ligands bound to COLEC12 is inferred.
Identifier: R-HSA-8862090
Species: Homo sapiens
Compartment: plasma membrane
Paired immunoglobulin-like type 2 receptor alpha (PILRA) binds to multiple ligands including CD99 (Shiratori et al. 2004), PILR-associating neural protein (PIANP, PANP) (Kogure et al. 2011), Herpes simplex virus-1 glycoprotein B (Satoh et al. 2008), Collectin-12 (COLEC12), Neural proliferation differentiation and control protein 1 (NPDC1) and C-type lectin domain family 4 member G (CLEC4G) (Sun et al. 2012). Binding studies suggest that PILR recognizes a complex ligand domain involving both silica acid and protein motif(s). Thus, PILR is evolved to engage multiple ligands with common molecular determinants to modulate myeloid cell functions in anatomical settings where PILR ligands are expressed. The precise function of PILRa-Ligand interaction is not well understood (Sun et al. 2012). PILRa negatively regulates inflammation and keeps myeloid system in check. Pilra KO mice produce more pathogenic cytokines during inflammation and are prone to enhanced autoimmune arthritis. Correspondingly, anti-PILRa mAb ameliorated inflammation in mouse arthritis models and suppressed the production of proinflammatory cytokines (Sun et al. 2014).
Cite Us!