Search results for COMT

Showing 13 results out of 14

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Protein (2 results from a total of 2)

Identifier: R-HSA-379386
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: COMT: P21964
Identifier: R-HSA-175974
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: COMT: P21964

Interactor (1 results from a total of 1)

Identifier: P21964-2
Species: Homo sapiens
Primary external reference: UniProt: P21964-2

Reaction (5 results from a total of 6)

Identifier: R-HSA-9679775
Species: Homo sapiens
Compartment: plasma membrane, extracellular region
Catechol-O-methyltransferase (COMT) is one of several enzymes that degrade catecholamines (such as dopamine, epinephrine, and norepinephrine) and various substances having a catechol structure. COMT inhibitors such as entacapone, tolcapone and opicapone are used in the treatment of Parkinson's disease.
Identifier: R-HSA-175983
Species: Homo sapiens
Compartment: cytosol
Dihydroxybenzoate is a typical substrate for Catechol O-methyltransferase
Identifier: R-HSA-379387
Species: Homo sapiens
Compartment: cytosol
Dopamine (DA) in the cytosol is methylated to 3-methoxytyramine (3MT) by catecholamine O-methyltransferase (COMT), which uses s-adenosylmethionine (AdoMet) as a methyl group donor (Männistö & Kaakkola 1991, Westerink & Spaan 1989).
Identifier: R-HSA-379464
Species: Homo sapiens
Compartment: cytosol, plasma membrane
3,4-dihydroxyphenylacetic acid (DOPAC), generated after oxidative deamination of dopamine by monoamine oxidase A (MAOA), is methylated by catecholamine O-methyltransferase (COMT) to homovanillic acid (HVA) (Deeds et al.1957).
Identifier: R-HSA-379393
Species: Homo sapiens
Compartment: extracellular region, plasma membrane, cytosol
The human gene SLC6A3 encodes the sodium-dependent dopamine transporter, DAT which mediates the re-uptake of dopamine from the synaptic cleft (Vandenbergh DJ et al, 2000). Dopamine can then be degraded by either COMT or monoamine oxidase.

Set (1 results from a total of 1)

Identifier: R-ALL-9679778
Compartment: extracellular region

Pathway (3 results from a total of 3)

Identifier: R-HSA-379397
Species: Homo sapiens
Dopamine once taken up by the dopamine transporter from the extracellular space into the cytosol is metabolized in a two step reaction to homovanillic acid.The first reaction is catalyzed by catecholamine o-methyl transferase and the subsequent reaction is catalyzed by monoamine oxidase A.
Identifier: R-HSA-379401
Species: Homo sapiens
The human gene SLC6A3 encodes the sodium-dependent dopamine transporter, DAT which mediates the re-uptake of dopamine from the synaptic cleft (Vandenbergh DJ et al, 2000). Dopamine can then be degraded by either COMT or monoamine oxidase.
Identifier: R-HSA-156581
Species: Homo sapiens
Methylation is a common but minor pathway of Phase II conjugation compared to glucuronidation or sulfonation. The cofactor used in methylation conjugation is S-adenosylmethionine (SAM). SAM is the second most widely used enzyme substrate after ATP and is involved in a wide range of important biological processes. SAM is sythesized from methionine's reaction with ATP, catalyzed by methionine adenosyltransferase (MAT). There are two genes, MAT1A and MAT2A, which encode for two homologous MAT catalytic subunits, 1 and 2.
During conjugation with nucleophilic substrates, the methyl group attached to the sulfonium ion of SAM is transferred to the substrate forming the conjugate. SAM, having lost the methyl moiety, is converted to S-adenosylhomocysteine (SAH). SAH can be hydrolyzed to form adenosine and homocysteine. Homocysteine can either be converted to glutathione or methylated to form methionine, thus forming the starting point for SAM synthesis and completing the cycle.
Fuctional groups attacked are phenols, catechols, aliphatic and aromatic amines and sulfhydryl-containing groups. The enzymes that catalyze the transfer of the methyl group to these functional groups are the methyltransferases (MT). MTs are small, cytosolic, monomeric enzymes that utilize SAM as a methyl donor. There are many MTs but the best studied ones are named on the basis of their prototypical substrates: COMT (catechol O-methyltransferase), TPMT (thiopurine methyltransferase), TMT (thiol methyltransferase), HNMT (histamine N-methyltransferase) and NNMT (nicotinamide N-methyltransferase). An example of each enzyme mentioned is given. In each case, a typical substrate for the enzyme is shown.

Complex (1 results from a total of 1)

Identifier: R-HSA-9679812
Species: Homo sapiens
Compartment: plasma membrane
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