Search results for CSF1R

Showing 12 results out of 16

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Types

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Protein (1 results from a total of 1)

Identifier: R-HSA-197667
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: CSF1R: P07333

DNA Sequence (1 results from a total of 1)

Identifier: R-HSA-8853905
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSG00000182578

Reaction (6 results from a total of 10)

Identifier: R-HSA-6787820
Species: Homo sapiens
Compartment: plasma membrane, extracellular region
The receptor for Interleukin-34 (IL34) is colony stimulating factor 1 receptor (CSF1R), also called macrophage colony stimulating factor receptor (M-CSF-R). Dimeric IL34 and CSF1 bind the same general region of CSF1R, interacting with overlapping but distinct epitopes. Ligand binding leads to receptor dimerisation (Ma et al. 2012, Liu et al. 2012). Like CSF1, IL34 stimulation of CSF1R leads to phosphorylation of extracellular signal-regulated kinase (ERK) 1 and 2 in human monocytes (Lin et al. 2008). CSF1R activates several signaling pathways including JAK-STAT3, 5A/B, phosphorylation of PIK3R1, PLCG2, GRB2, SLA2 and CBL. PLCG2 phosphorylation leads to increassed production of the cellular signaling molecules diacylglycerol (DAG) and inositol 1,4,5 trisphosphate (IP3), which activate protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3 kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of MAPK1 (ERK2) or MAPK3 (ERK1) and the SRC family kinases SRC, FYN and YES1. Activated CSF1R binds GRB2 and promotes tyrosine phosphorylation of SHC1 and INPP5D (SHIP1). Signaling is down regulated by protein phosphatases such as INPP5D that can dephosphorylate the receptor and its downstream effectors.
Identifier: R-HSA-9009554
Species: Homo sapiens
Compartment: extracellular region, plasma membrane
Interleukin-34 (IL34) can bind Syndecan-1 (SDC1), a cell surface proteoglycan. Low levels of SDC1 may sequester IL34 at the cell surface and prevent it from binding Macrophage colony-stimulating factor 1 receptor (CSF1R), while high SDC1 levels may facilitate IL34-CSF1R signaling (Segaliny et al. 2015). Ultimately, these events lead to the release of pro-inflammatory chemokines regulating the innate immunity and inflammation. The precise interaction between IL34:SDC1 and CSF1R is unknown. Hence, this interaction is represented as an uncertain black box event.
Identifier: R-HSA-9009485
Species: Homo sapiens
Compartment: extracellular region, plasma membrane
Interleukin-34 (IL34) can bind Macrophage colony-stimulating factor 1 (CSF1). The IL34:CSF1 heteromer may bind Macrophage colony-stimulating factor 1 receptor (CSF1R) facilitating receptor maturation and cellular trafficking. Consequently, downstream signaling pathways are activated (Segaliny et al. 2015). Ultimately, these events lead to the release of pro-inflammatory chemokines regulating the innate immunity and inflammation. The exact binding mechanism of IL34:CSF1 to CSF1R is unclear. Hence, this interaction is represented as a black box event.
Identifier: R-HSA-8853908
Species: Homo sapiens
Compartment: nucleoplasm, plasma membrane
Binding of VENTX to the homeobox domain binding (HDB) site in the promoter of the macrophage colony stimulating factor receptor (M-CSFR, CSF1R) gene results in up-regulation of CSF1R transcription. Expression of CSF1R is necessary for differentiation of monocytes into macrophages (Wu et al. 2011).
Identifier: R-HSA-8853898
Species: Homo sapiens
Compartment: nucleoplasm
VENTX binds to the homeodomain binding site (HDB) in the promoter of the macrophage colony stimulating factor receptor (M-CSFR, CSF1R) gene (Wu et al. 2011).
Identifier: R-HSA-448632
Species: Homo sapiens
Compartment: extracellular region
interleukin-34 (IL34) was identified as a potent activator of monocytes and macrophages, signaling through Colony-stimulating factor-1 (CSF1) receptor (CSF1R) with a distinct tissue distribution from CSF1 (Lin et al. 2008). IL34 and CSF1 share many functional properties. IL34 has no appreciable sequence similarity with any other protein but shares a four-helix bundle structure seen in CSF1 (Garceau et al. 2010, Liu et al. 2012). IL34 forms a noncovalently linked dimer (Ma et al. 2012) whereas CSF1 contains an intersubunit disulfide bond. The structure of the IL34:CSF1R complex shows a similar ligand-receptor assembly to that of CSF1:CSF1R.

Complex (3 results from a total of 3)

Identifier: R-HSA-9009560
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-9009491
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-6787825
Species: Homo sapiens
Compartment: plasma membrane

Pathway (1 results from a total of 1)

Identifier: R-HSA-8853884
Species: Homo sapiens
The VENTX (also known as VENT homeobox or VENTX2) gene is a member of the homeobox family of transcription factors. The ortholog of VENTX was first described in Xenopus where it participates in BMP and Nanog signaling pathways and controls dorsoventral mesoderm patterning (Onichtchouk et al. 1996, Scerbo et al. 2012). The zebrafish ortholog of VENTX is also involved in dorsoventral patterning in the early embryo (Imai et al. 2001). Rodents lack the VENTX ortholog (Zhong and Holland 2011). VENTX is expressed in human blood cells (Moretti et al. 2001) and appears to play an important role in hematopoiesis. The role of VENTX in hematopoiesis was first suggested based on its role in mesoderm patterning in Xenopus and zebrafish (Davidson and Zon 2000). VENTX promotes cell cycle arrest and differentiation of hematopoietic stem cells and/or progenitor cells (Wu, Gao, Ke, Giese and Zhu 2011, Wu et al. 2014). Ventx suppression leads to expansion of hematopoietic stem cells and multi-progenitor cells (Gao et, J. Biol.Chem, 2012). VENTX induces transcription of cell cycle inhibitors TP53 (p53) and p16INK4A and activates tumor suppressor pathways regulated by TP53 and p16INK4A (Wu, Gao, Ke, Hager et al. 2011), as well as macrophage colony stimulating factor receptor (CSF1R) (Wu, Gao, Ke, Giese and Zhu 2011) and inhibits transcription of cyclin D1 (CCND1) (Gao et al. 2010) and Interleukin-6 (IL6) (Wu et al. 2014). Chromatin immunoprecipitation showed that EGR3 transcription factor directly binds to the promoter of IL6 and IL8 genes (Baron VT et al, BJC 2015). While VENTX expression may suppress lymphocytic leukemia (Gao et al. 2010), high levels of VENTX have been reported in acute myeloid leukemia cells, with a positive effect on their proliferation (Rawat et al. 2010). Another homeobox transcription factor that regulates differentiation of hematopoietic stemm cells is DLX4 (Bon et al. 2015). Studies on colon cancer showed that VentX regulates tumor associated macrophages and reverts immune suppression in tumor microenvironment (Le et al. 2018). MEK1 is required for Xenopus Ventx2 asymmetric distribution during blastula cell division. Ventx2 inhibition by MEK1 is required for embryonic cell commitment (Scerbo et al, eLife, 2017). VENTX induces TP53-independent apoptosis in cancer cells (Gao H, Oncotarget, 2016). During Xenopus embryonic development, VENTX ortholog regulates transcription of the sox3 gene (Rogers et al. 2007) as well as the early neuronal gene zic3 (Umair et al. 2018).
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