Search results for CTGF

Showing 6 results out of 6

×

Species

Types

Compartments

Reaction types

Search properties

Species

Types

Compartments

Reaction types

Search properties

Protein (1 results from a total of 1)

Identifier: R-HSA-561148
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: CCN2: P29279

DNA Sequence (1 results from a total of 1)

Identifier: R-HSA-5649937
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSG00000118523

Reaction (2 results from a total of 2)

Identifier: R-HSA-1989766
Species: Homo sapiens
Compartment: nucleoplasm, extracellular region
The CTGF gene is transcribed to yield mRNA and the mRNA is translated to yield protein. Transcription of the CTGF gene is increased by both YAP1:TEAD and WWTR1(TAZ):TEAD transcriptional coactivator:transcription factor complexes, so that CTGF is one of the many genes whose expression is downregulated by the action of the hippo cascade (Zhang et al. 2009; Zhao et al. 2008).
Identifier: R-HSA-8951695
Species: Homo sapiens
Compartment: nucleoplasm
The complex of YAP1 and one TEAD proteins (TEAD1, TEAD2, TEAD3 or TEAD4) binds to TEAD-binding sites in the promoter of the CTGF gene (Zhao et al. 2008). Association of RUNX3 with the TEADs:YAP1 complex inhibits loading of the TEADs:YAP1 to the CTGF promoter (Qiao et al. 2016).

Complex (1 results from a total of 1)

Identifier: R-HSA-8951697
Species: Homo sapiens
Compartment: nucleoplasm

Pathway (1 results from a total of 1)

Identifier: R-HSA-8951671
Species: Homo sapiens
Association of RUNX3 with the TEADs:YAP1 complex inhibits loading of the TEADs:YAP1 to the CTGF promoter, thus negatively regulating transcription of the CTGF gene which encodes the Connective tissue growth factor (Yagi et al. 1999, Zhao et al. 2008, Qiao et al. 2016).
Cite Us!