Search results for CTSG

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Reaction (4 results from a total of 4)

Fibronectin degradation by CTSG

Identifier: R-HSA-3785684
Species: Homo sapiens
Compartment: plasma membrane
Plasma fibronectin (FN1) is degraded by cathepsin G (CTSG) into a characteristic pattern of gelatin-binding peptides of M, = 64000, 40000, and 30000 (Vartio et al. 1981, Vartio 1982). CTSG is activated by UV exposure and can activate matrix metalloproteinases MMP1 and MMP2, but increased levels of MMP activity did not correlate with increased FN degradation in normal human fibroblasts (NHFs) following exposure to UVB (50 mJ/cm2) irradiation, while addtion of CTSG inhibitor decreased FN degradation, suggesting that CTSG is directly responsible for FN1 degradation (Son et al. 2009).

CTSG cleaves CASP1(1-404)

Identifier: R-HSA-448678
Species: Homo sapiens
Compartment: cytosol
Caspase 1 is expressed as a precursor that is cleaved to generate the p10 and p20 subunits that subsequently form the active tetramer.

ELANE, CTSG or PRTN3 binds bacteria

Identifier: R-HSA-6813659
Species: Homo sapiens
Compartment: extracellular region, plasma membrane
Polymorphonuclear neutrophils (PMNs) are the most abundant circulating blood leukocytes that are rapidly recruited to sites of infection by host- and/or pathogen-derived components. PMNs provide the first-line defense against infection killing invading pathogens and resolving the inflammation they cause (Kobayashi SD et al. 2005). Activated neutrophils are known to release a variety of molecules, including the neutrophil serine proteases such as neutrophil elastase (ELINE), proteinase 3 (PRTN3) and cathepsin G (CTSG) (Garwicz D et al. 2005). Neutrophil serine proteases contribute to antimicrobial defense by
  • attacking membrane-associated (E. coli) or capsule proteins (S.pneumonia), which leads to loss of membrane integrity (Belaaouaj A et al. 2000; Standish AJ & Weiser JN 2009)
  • processing host immune proteins to generate antimicrobial peptides that can directly kill bacteria (Sorensen OE et al. 2001)
  • targeting and inactivating bacterial virulence factors to attenuate bacteria (Weinrauch Y et al. 2002; Lopez-Boado YS et al. 2004)

Rv3364c binds cathepsin G

Identifier: R-HSA-9635424
Species: Homo sapiens
Compartment: cytosol
Mtb secretes serine protease inhibitor Rv3364c (Rv3364c) protein into the phagocyte's cytosol which blocks the serine protease activity of human cathepsin G (CTSG), inhibiting the cleavage of caspase-1 (Danelishvili et al. 2011).
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