Search results for CYB5R3
Showing 6 results out of 6
Protein (3 results from a total of 3)
Identifier: R-HSA-6799217
Species:
Homo sapiens
Compartment:
azurophil granule lumen
Primary external reference: UniProt: CYB5R3:
P00387
Identifier: R-HSA-6806205
Species:
Homo sapiens
Compartment:
extracellular region
Primary external reference: UniProt: CYB5R3:
P00387
Identifier: R-HSA-198771
Species:
Homo sapiens
Compartment:
mitochondrial outer membrane
Primary external reference: UniProt: CYB5R3:
P00387
Complex (1 results from a total of 1)
Identifier: R-HSA-198850
Species:
Homo sapiens
Compartment:
mitochondrial outer membrane
Reaction (2 results from a total of 2)
Identifier: R-HSA-198824
Species:
Homo sapiens
Compartment:
cytosol,
mitochondrial outer membrane
Cytochrome b5 reductase (CYB5R3) catalyzes the reduction of cytosolic ferric CYB5A (CYB5A:ferriheme) to ferrous CYPB5A (CYB5A:heme), coupled to the conversion of NADH to NAD+ (Shirabe et al. 1995). CYB5R3 is associated with the outer mitochondrial membrane via a myristoyl group added post-translationally to glycine residue 2 of the protein (Borgese et al. 1993).
Identifier: R-HSA-8936442
Species:
Homo sapiens
Compartment:
cytosol,
mitochondrial outer membrane
Mitochondrial amidoxime-reducing components 1 and 2 (MARC1 and 2) are Mo-molybdopterin (Mo-MPT) cofactor-dependent, outer mitochondrial membrane-associated enzymes capable of reducing N-hydroxylated prodrugs and N-hydroxy-L-arginine (NOHA) and N-hydroxy-N-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively. They are components of an N-hydroxylated prodrug-converting complex, also containing cytochrome b5 (CYB5B) and NADH cytochrome b5 reductase 3 (CYB5R3) (Jakobs et al. 2014, Gruenewald et al. 2008, Ott et al. 2014, 2015). The reduction of NOHA is described in this reaction.
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