Search results for CYP2C8

Showing 5 results out of 5

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Species

Types

Compartments

Reaction types

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Protein (1 results from a total of 1)

CYP2C8

Identifier: R-HSA-211009
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: CYP2C8: P10632

Reaction (3 results from a total of 3)

CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation

Identifier: R-HSA-211910
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane, endoplasmic reticulum lumen
Paclitaxel (Taxol) is a naturally occurring member of the taxane family of antitumor drugs. It acts by stabilizing microtubules. Paclitaxel is inactivated in human liver by CYP2C8, which catalyzes 6alpha-hydroxylation of paclitaxel.

Arachidonic acid is hydroxylated to 19-HETE by CYP(2)

Identifier: R-HSA-2161814
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane, endoplasmic reticulum lumen
Several cytochrome P450s (CYPs) convert arachidonic acid to 19-hydroxyeicosatetraenoic acid (19-HETE). The CYPs and their references are as follows: CYP2C8 (Bylund et al. 1998); CYP2C9 (Bylund et al. 1998); CYP2C19 (Bylund et al. 1998); CYP4A11 (Gainer et al. 2005); CYP2U1 (Chuang et al. 2004); CYP1A1, CYP1A2, CYP1B1 (Choudhary et al. 2004).

Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)

Identifier: R-HSA-2161899
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane, cytosol
Several cytochrome P450s (CYPs) convert arachidonic acid to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acids (8,9-, 11,12-, 14,15-EETs). The CYPs and their references are as follows: CYP1A1, CYP1A2, CYP1B1 (Choudhary et al. 2004); CYP2C8, CYP2C9 (Rifkind et al. 1995); CYP2C19 (Bylund et al. 1998, Rifkind et al. 1995); CYP2J2 (Wu et al. 1996).

Set (1 results from a total of 1)

Cytochrome P450 (CYP2C8 based)

Identifier: R-HSA-3215460
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis. Further candidates were identified by Ralf Stephan in a July 15, 2023 analysis.
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