Search results for CYP51A1

Showing 9 results out of 9

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Species

Types

Compartments

Reaction types

Search properties

Protein (1 results from a total of 1)

Identifier: R-HSA-194721
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: CYP51A1: Q16850

DNA Sequence (1 results from a total of 1)

Identifier: R-HSA-5660427
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSEMBL:ENSG00000001630

Reaction (5 results from a total of 5)

Identifier: R-HSA-9621404
Species: Homo sapiens
Compartment: nucleoplasm, endoplasmic reticulum membrane
CYP51A1 encodes lanosterol 14 alpha-demethylase, an enzyme involved in steroid biosynthesis (Stroemstedt et al, 1996; Strushkevich et al, 2010). CYP51A1 is upregulated during Schwann cell myelination in an EGR2- and SREBF2-dependent manner, and sites for these factors have been identified in the upstream promoter region (Nagarajan et al, 2001; Halder et al, 2002; LeBlanc et al, 2005; Jang et al, 2010).
Identifier: R-HSA-194678
Species: Homo sapiens
Compartment: cytosol, endoplasmic reticulum membrane
Lanosterol 14-alpha demethylase (CYP51A1) catalyses oxidative C14-demethylation of lanosterol (LNSOL) to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol (4,4DMCHOLtrienol). Although the reaction is annotated here as a single concerted event, studies with purified rat enzyme indicate that the methyl group is converted successively to an alcohol and an aldehyde before being released as formate (Stromstedt et al. 1996, Strushkevich et al. 2010).
Identifier: R-HSA-2426163
Species: Homo sapiens
Compartment: nucleoplasm
SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the CYP51A1 gene (Pai et al. 1998, Reed et al. 2008, Rome et al. 2008). SREBP1A and SREBP2 activate CYP51A1 equally (Pai et al. 1998).
Identifier: R-HSA-9621406
Species: Homo sapiens
Compartment: nucleoplasm
CYP51A1 encodes lanosterol 14 alpha-demethylase, a protein involved in steroid biosynthetic pathways (Stromstedt et al, 1996; Strushkevich et al, 2010). Consistent with its expression during Schwann cell myelination, expression is synergistically activated by EGR2 and SREBF2 acting through cognate sites in the promoter (Nagarajan et al, 2001; Halder et al, 2002; LeBlanc et al, 2005; Jang et al, 2010).
Identifier: R-HSA-1655847
Species: Homo sapiens
Compartment: nucleoplasm, endoplasmic reticulum membrane
The CYP51A1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
SREBF1A (SREBP1A) and SREBF2 (SREBP2) bind the promoter of the Lanosterol Demethylase (CYP51A1) gene and enhance transcription (Pai et al. 1998, Sakakura et al. 2001, Halder et al. 2002, Reed et al. 2008, reviewed in Horton et al. 2002).

Complex (2 results from a total of 2)

Identifier: R-HSA-9621347
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-2426132
Species: Homo sapiens
Compartment: nucleoplasm
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