Search results for DLC1

Showing 7 results out of 24

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Protein (1 results from a total of 7)

Identifier: R-HSA-5625335
Species: Homo sapiens
Compartment: ciliary tip
Primary external reference: UniProt: DYNLL1: P63167

Reaction (6 results from a total of 13)

Identifier: R-HSA-9018806
Species: Homo sapiens
Compartment: plasma membrane, cytosol
The following GTPase activating proteins (GAPs) were shown to bind RAC3 and stimulate its GTPase activity, resulting in GTP to GDP hydrolysis and conversion of the active RAC3:GTP complex into the inactive RAC3:GDP complex (the high throughput screen by Bagci et al. 2020, cited as supporting evidence, examined binding of GAPs to constitutively active RAC3 mutant without looking at activation of the RAC3 GTPase activity):
ARHGAP1 (Amin et al. 2016; supported by Bagci et al. 2020)
ARHGAP6 (Li et al. 2016)
ARHGAP15 (Zamboni et al. 2016)
ARHGAP26 (Amin et al. 2016)
ARHGAP35 (Amin et al. 2016; supported by Bagci et al. 2020)
RACGAP1 (Amin et al. 2016; supported by Bagci et al. 2020)

The following GAPs, annotated as candidate RAC3 GAPs, were shown to bind RAC3 and stimulate its GTPase activity in some but not all studies or were shown to bind to the constitutively active RAC3 mutant without testing for activation of RAC3 GTPase activity, as indicated:
ABR (Amin et al. 2016: RAC3 directed GAP activity; Bagci et al. 2020: no binding to active RAC3)
ARAP2 (Bagci et al. 2020: binding to active RAC3)
ARAP3 (Bagci et al. 2020: binding to active RAC3)
ARHGAP5 (Bagci et al. 2020: binding to active RAC3)
ARHGAP17 (Amin et al. 2016: RAC3 directed GAP activity; Bagci et al. 2020: no binding to active RAC3)
ARHGAP21 (Bagci et al. 2020: binding to active RAC3)
ARHGAP32 (Bagci et al. 2020: binding to active RAC3)
ARHGAP39 (Bagci et al. 2020: binding to active RAC3)
ARHGAP42 (Bagci et al. 2020: binding to active RAC3)
BCR (Haataja et al. 1997: RAC3 directed GAP activity; Bagci et al. 2020: no binding to active RAC3)
DEPDC1B (Bagci et al. 2020: binding to active RAC3)
OCRL (Bagci et al. 2020: binding to active RAC3; Erdmann et al. 2007; Lichter Konecki et al. 2006: no RAC3 directed GAP activity:)
OPHN1 (Amin et al. 2016: RAC3 directed GAP activity; Bagci et al. 2020: no binding to active RAC3)
PIK3R1 (Bagci et al. 2020: binding to active RAC3)
PIK3R2 (Bagci et al. 2020: binding to active RAC3)
SRGAP2 (Bagci et al. 2020: binding to active RAC3)
SYDE1 (Bagci et al. 2020: binding to active RAC3)

The following GAPs have been shown to not act on RAC3 or were shown to not bind to the constitutively active RAC3 mutant by Bagci et al. 2020:
ARHGAP12 (Bagci et al. 2020)
ARHGAP29 (Bagci et al. 2020)
ARHGAP31 (Bagci et al. 2020)
DLC1 (Amin et al. 2016)
MYO9A (Bagci et al. 2020)
MYO9B (Bagci et al. 2020)
STARD13 (Amin et al. 2016)
STARD8 (Amin et al. 2016)
Identifier: R-HSA-9013022
Species: Homo sapiens
Compartment: cytosol, plasma membrane
The following GTPase activating proteins (GAPs) were shown to bind RHOB and stimulate its GTPase activity, resulting in GTP to GDP hydrolysis and conversion of the active RHOB:GTP complex into the inactive RHOB:GDP complex (the high throughput study by Bagci et al. 2020 examined binding to the active RHOB mutant but not activation of RHOB GTPase activity):
ABR (Amin et al. 2016, supported by Bagci et al. 2020)
ARHGAP1 (Amin et al. 2016, supported by Bagci et al. 2020)
ARHGAP5 (Kusama et al. 2006, supported by Bagci et al. 2020)
ARHGAP26 (Amin et al. 2016)
DLC1 (Healy et al. 2008, Amin et al. 2016)
MYO9B (Graf et al. 2000, supported by Bagci et al. 2020)
STARD13 (Amin et al. 2016)

The following GAPs were shown to bind RHOB and stimulate its GTPase activity in some but not all studies or have only been shown to bind to the active RHOB (as indicated) and are annotated as candidate RHOB GAPs:
ARHGAP21 (Bagci et al. 2020: binds to active RHOB)
ARHGAP32 (Bagci et al. 2020: binds to active RHOB)
ARHGAP35 (RHOB directed GAP activity: Amin et al. 2016; Bagci et al. 2020: no binding to active RHOB)
ARHGAP39 (Bagci et al. 2020: binds to active RHOB)
BCR (Bagci et al. 2020: binds to active RHOB)
DEPDC1B (Bagci et al. 2020: binds to active RHOB)
MYO9A (Bagci et al. 2020: binds to active RHOB)
OPHN1 (RHOB directed GAP activity: Amin et al. 2016; Bagci et al. 2020: no binding to active RHOB)
PIK3R1 (Bagci et al. 2020: binds to active RHOB)
PIK3R2 (Bagci et al. 2020: binds to active RHOB)
RACGAP1 (RHOB directed GAP activity: Amin et al. 2016; Bagci et al. 2020: no binding to active RHOB)
STARD8 (RHOB directed GAP activity: Braun et al. 2015; no RHOB directed GAP activity: Amin et al. 2016)

The following GAPs do not act on RHOB or were shown to not bind to the active RHOB, without testing for the ability to activate RHOB GTPase activity (as indicated):
ARAP2 (Bagci et al. 2020: does not bind active RHOB)
ARAP3 (Bagci et al. 2020: does not bind active RHOB)
ARHGAP12 (Bagci et al. 2020: does not bind active RHOB)
ARHGAP17 (Amin et al. 2016; Bagci et al. 2020: does not bind active RHOB)
ARHGAP29 (Bagci et al. 2020: does not bind active RHOB)
ARHGAP31 (Bagci et al. 2020: does not bind active RHOB)
ARHGAP42 (Bagci et al. 2020: does not bind active RHOB)
SRGAP2 (Bagci et al. 2020: does not bind active RHOB)
SYDE1 (Bagci et al. 2020: does not bind active RHOB)
Identifier: R-HSA-9014295
Species: Homo sapiens
Compartment: cytosol, plasma membrane
The following GTPase -activating proteins (GAPs) were shown to bind RAC2 and stimulate its GTPase activity, resulting in GTP to GDP hydrolysis and conversion of the active RAC2:GTP complex into the inactive RAC2:GDP complex (the high throughput study by Bagci et al. 2020 is cited as supporting evidence, because it examined binding of GAPs to constitutively active RAC2 mutant but did not examine GAP-mediated activation of RAC2 GTPase activity):
ARHGAP1 (Amin et al. 2016; supported by Bagci et al. 2020)
ARHGAP26 (Amin et al. 2016)
ARHGAP35 (Amin et al. 2016; Bagci et al. 2020)

The following GAPs, annotated as candidate RAC2 GAPs, were shown to bind RAC2 and stimulate its GTPase activity in some but not all studies or were shown to bind to constitutively active RAC2 mutant (Bagci et al. 2020) but their ability to activate RAC2 GTPase activity has not been tested:
ABR (Chuang et al. 1995: RAC2 directed GAP activity; Amin et al. 2016: no RAC2 directed GAP activity; Bagci et al. 2020: no binding t active RAC2)
ARHGAP17 (Amin et al. 2016: RAC2 directed GAP activity; Bagci et al. 2020: no binding to active RAC2)
ARHGAP21 (Bagci et al. 2020: binding to active RAC2)
ARHGAP32 (Bagci et al. 2020: binding to active RAC2)
ARHGAP39 (Bagci et al. 2020: binding to active RAC2)
ARHGAP42 (Bagci et al. 2020: binding to active RAC2)
BCR (Chuang et al. 1995: RAC2 directed GAP activity; Bagci et al. 2020: no binding to active RAC2)
DEPDC1B (Bagci et al. 2020)
OPHN1 (Amin et al. 2016: RAC2 directed GAP activity; Bagci et al. 2020: no binding to active RAC2)
PIK3R1 (Bagci et al. 2020: binding to active RAC2)
PIK3R2 (Bagci et al. 2020: binding to active RAC2)
RACGAP1 (Amin et al. 2016: RAC2 directed GAP activity; Bagci et al. 2020: no binding to active RAC2)
SYDE1 (Bagci et al. 2020: binding to active RAC2)

The following GAPs do not act on RAC2 or were shown by Bagci et al. 2020 to not bind to active RAC2:
ARAP2 (Bagci et al. 2020)
ARAP3 (Bagci et al. 2020)
ARHGAP5 (Bagci et al. 2020)
ARHGAP12 (Bagci et al. 2020)
ARHGAP29 (Bagci et al. 2020)
ARHGAP31 (Bagci et al. 2020)
DLC1 (Amin et al. 2016)
MYO9A (Bagci et al. 2020)
MYO9B (Bagci et al. 2020)
OCRL (Lichter Konecki et al. 2006; Erdmann et al. 2007; Bagci et al. 2020)
SRGAP2 (Bagci et al. 2020)
STARD8 (Amin et al. 2016)
STARD13 (Amin et al. 2016)
Identifier: R-HSA-9013111
Species: Homo sapiens
Compartment: plasma membrane, cytosol
The following GTPase activating proteins (GAPs) were shown to bind RHOC and stimulate its GTPase activity, resulting in GTP to GDP hydrolysis and conversion of the active RHOC:GTP complex into the inactive RHOC:GDP complex, or they were shown to bind to the constitutively active RHOC mutant in the high throughput screen conducted by Bagci et al. 2020, without testing for activation of RHOC GTPase activity (as indicated):
ARHGAP1 (Amin et al. 2016; supported by Bagci et al. 2020)
ARHGAP5 (Kusama et al. 2006; supported by Bagci et al. 2020)
ARHGAP18 (Chang et al. 2014)
ARHGAP26 (Amin et al. 2016)
DLC1 (Healy et al. 2008; Amin et al. 2016)
MYO9B (Graf et al. 2000; supported by Bagci et al. 2020)
RACGAP1 (Amin et al. 2016; supported by Bagci et al. 2020)
STARD13 (Amin et al. 2016)

The following GAPs were shown to bind RHOC and stimulate its GTPase activity in some but not all studies, or only their binding to the constitutively active RHOC mutant was shown without testing for activation of RHOC GTPase activity, and they are annotated as candidate RHOC GAPs:
ABR (Amin et al. 2016: RHOC directed GAP activity; Bagci et al. 2020: no binding to active RHOC)
ARHGAP21 (Lazarini et al. 2013: RHOC directed GAP activity; Bagci et al. 2020: no binding to active RHOC)
ARHGAP32 (Bagci et al. 2020: binding to active RHOC)
ARHGAP35 (Amin et al. 2016: RHOC directed GAP activity; Bagci et al. 2020: no binding to active RHOC)
ARHGAP39 (Bagci et al. 2020: binding to active RHOC)
BCR (Bagci et al. 2020: binding to active RHOC)
DEPDC1B (Bagci et al. 2020: binding to active RHOC)
OPHN1 (Amin et al. 2016: RHOC directed GAP activity; Bagci et al. 2020: no binding to active RHOC)
PIK3R1 (Bagci et al. 2020: binding to active RHOC)

The following GAPs do not act on RHOC or do not bind to the constitutively active RHOC mutant:
ARAP2 (Yoon et al. 2006; Bagci et al. 2020: no binding to active RHOC)
ARAP3 (Bagci et al. 2020: no binding to active RHOC)
ARHGAP12 (Bagci et al. 2020: no binding to active RHOC)
ARHGAP17 (Amin et al. 2016; Bagci et al. 2020: no binding to active RHOC)
ARHGAP29 (Bagci et al. 2020: no binding to active RHOC)
ARHGAP31 (Bagci et al. 2020: no binding to active RHOC)
ARHGAP42 (Bagci et al. 2020: no binding to active RHOC)
MYO9A (Bagci et al. 2020: no binding to active RHOC)
OCRL (Erdmann et al. 2006;Lichter Konecki et al. 2006; Bagci et al. 2020: no binding to active RHOC)
PIK3R2 (Bagci et al. 2020: no binding to active RHOC)
SRGAP2 (Bagci et al. 2020: no binding to active RHOC)
STARD8 (Amin et al. 2016)
SYDE1 (Bagci et al. 2020: no binding to active RHOC)
Identifier: R-HSA-9013144
Species: Homo sapiens
Compartment: plasma membrane, cytosol
The following GTPase activating proteins (GAPs) were shown to bind RAC1 and stimulate its GTPase activity, resulting in GTP to GDP hydrolysis and conversion of the active RAC1:GTP complex into the inactive RAC1:GDP complex (the high throughput screen by Bagci et al. 2020 examined binding of GAPs to constitutively active RAC1 mutant without testing for activation of RAC1 GTPase activity and is cited as supporting evidence, as indicated):
ARHGAP4 (Vogt et al. 2007; Müller et al. 2020)
ARHGAP9 (Furukawa et al. 2001; Müller et al. 2020)
ARHGAP15 (Seoh et al. 2003; Zamboni et al. 2016; Müller et al. 2020)
ARHGAP20 (Müller et al. 2020)
ARHGAP22 (Mori et al. 2014; Müller et al. 2020)
ARHGAP23 (Martin Vilchez et al. 2017; Müller et al. 2020)
ARHGAP27 (Sakakibara et al. 2004; Müller et al. 2020)
ARHGAP30 (Naji et al. 2011; Müller et al. 2020)
ARHGAP31 (Tcherkezian et al. 2006; Müller et al. 2020; supported by Bagci et al. 2020)
ARHGAP39 (Lundström et al. 2004; Müller et al. 2020; supported by Bagci et al. 2020)
ARHGAP44 (Raynaud et al. 2014; Müller et al. 2020)
CHN1 (Ahmed et al. 1994; Caloca et al. 2008; Müller et al. 2020)
CHN2 (Canagarajah et al. 2004; Caloca et al. 2003; Müller et al. 2020)
FAM13A (Müller et al. 2020)
FAM13B (Müller et al. 2020)
HMHA1 (de Kreuk et al. 2013)
RALBP1 (Jullien Flores et al. 1995; Müller et al. 2020)
SH3BP1 (Müller et al. 2020)
SRGAP2 (Mason et al. 2011; Guo and Bao 2010; Müller et al. 2020; supported by Bagci et al. 2020)
SRGAP3 (Endris et al. 2002; Müller et al. 2020)
SYDE2 (Müller et al. 2020)
TAGAP (Bauer et al. 2005; Müller et al. 2020)

The following GAPs were shown to bind RAC1 and stimulate its GTPase activity in some but not all studies and are annotated as candidate RAC1 GAPs (the high throughput screen by Bagci et al. 2020 examined binding of GAPs to constitutively active RAC1 mutant without testing for activation of RAC1 GTPase activity and is cited as supporting evidence, as indicated):
ABR (Chuang et al. 1995, Um et al. 2014, Amin et al. 2016; Müller et al. 2020: RAC1 directed GAP activity; Bagci et al. 2020: no binding to active RAC1)
ARAP1 (Müller et al. 2020: RAC1-directed GAP activity; Miura et al. 2002: no RAC1-directed GAP activity)
ARAP2 (Müller et al. 2020: RAC1 directed GAP activity; Bagci et al. 2020: binding to active RAC1; Yoon et al. 2006: no RAC1 directed GAP activity)
ARAP3 (Krugmann et al. 2002, Müller et al. 2020: RAC1 directed GAP activity; Bagci et al. 2020: no binding to active RAC1)
ARHGAP1 (Amin et al. 2016: RAC1 directed GAP activity; Li et al. 2009, Yang et al. 2006, Müller et al. 2020: no RAC1 directed GAP activity; Bagci et al. 2020: no binding to active RAC1)
ARHGAP5 (Burbelo et al. 1995: RAC1-directed GAP activity; Bagci et al. 2020: binding to active RAC1; Müller et al. 2020: no RAC1-directed GAP activity)
ARHGAP10 (Shibata et al. 2001: RAC1-directed GAP activity; Müller et al. 2020: no RAC1-directed GAP activity)
ARHGAP12 (Müller et al. 2020: RAC1-directed GAP activity; Bagci et al. 2020: no binding to active RAC1)
ARHGAP17 (Richnau and Aspenstrom 2001, Amin et al. 2016: RAC1 directed GAP activity; Müller et al. 2020: no RAC1 directed GAP activity; Bagci et al. 2020: no binding to active RAC1)
ARHGAP21 (Bagci et al. 2020: binding to active RAC1; Sousa et al. 2005, Müller et al. 2020: no RAC1 directed GAP activity)
ARHGAP24 (Lavelin and Geiger 2005, Ohta et al. 2006: RAC1 directed GAP activity; Su et al. 2004, Müller et al. 2020: no RAC1 directed GAP activity)
ARHGAP25 (Csépányi Kömi et al. 2016, Csépányi Kömi et al. 2012: RAC1-directed GTPase activity; Müller et al. 2020: no RAC1-directed GAP activity)
ARHGAP26 (Amin et al. 2016: RAC1 directed GAP activity; Sheffield et al. 1999, Müller et al. 2020: no RAC1 directed GAP activity)
ARHGAP29 (Saras et al. 1997: RAC1 directed GAP activity; Müller et al. 2020: no RAC1 directed GAP activity; Bagci et al. 2020: no binding to active RAC1)
ARHGAP32 (Nakazawa et al. 2003: RAC1-directed GAP activity; Bagci et al. 2020: binding to active RAC1; Müller et al. 2020: no RAC1-directed GAP activity)
ARHGAP33 (Müller et al. 2020: RAC1-directed GAP activity; Liu et al. 2006: no RAC1-directed GAP activity)
ARHGAP35 (Lévay et al. 2009, Amin et al. 2016, Müller et al. 2020: RAC1 directed GAP activity; Bagci et al. 2020: no binding to active RAC1)
ARHGAP42 (Bagci et al. 2020: binding to active RAC1; Bai et al. 2013: no RAC1 directed GAP activity)
BCR (Um et al. 2014, Chuang et al. 1995, Müller et al. 2020: RAC1 directed GAP activity; Bagci et al. 2020: no binding to active RAC1)
DEPDC1B (Wu et al. 2015: RAC1-directed GAP activity; Bagci et al. 2020: binding to active RAC1; Müller et al. 2020: no RAC1-directed GAP activity)
DLC1 (Amin et al. 2016: RAC1 directed GAP activity; Homma and Emori 1995, Müller et al. 2020: no RAC1 directed GAP activity)
GMIP (Müller et al. 2020: RAC1-directed GAP activity; Aresta et al. 2002: no RAC1-directed GAP activity)
MYO9B (Müller et al. 2020: RAC1-directed GAP activity; Post et al. 1998, Kong et al. 2015: no RAC1-directed GAP activity; Bagci et al. 2020: no binding to active RAC1)
OPHN1 (Niermann et al. 2016, Billuart et al. 1998, Elvers et al. 2012, Amin et al. 2016: RAC1 directed GAP activity; Müller et al. 2020: no RAC1 directed GAP activity; Bagci et al. 2020: no binding to active RAC1)
PIK3R1 (Bagci et al. 2020: binding to active RAC1; Müller et al. 2020: no RAC1-directed GAP activity)
PIK3R2 (Bagci et al. 2020: binding to active RAC1; Müller et al. 2020: no RAC1-directed GAP activity)
RACGAP1 (Touré et al. 1998, Amin et al. 2016, Müller et al. 2020: RAC1 directed GAP activity; Bagci et al. 2020: no binding to active RAC1)
SRGAP1 (Müller et al. 2020: RAC1-directed GAP activity; Wong et al. 2001: no RAC1-directed GAP activity)

The following GAPs do not act on RAC1 or were shown by Bagci et al. 2020 to not bind constitutively active RAC1 mutant, as indicated:
ARHGAP6 (Prakash et al. 2000; Müller et al. 2020)
ARHGAP8 (Lua and Low 2004; Müller et al. 2020)
ARHGAP11A (Lawson et al. 2016; Müller et al. 2020)
ARHGAP11B (Florio et al. 2015; Müller et al. 2020)
ARHGAP18 (Maeda et al. 2011; Müller et al. 2020)
ARHGAP19 (David et al. 2014; Müller et al. 2020)
ARHGAP28 (Yeung et al. 2014; Müller et al. 2020)
ARHGAP36 (Rack et al. 2014; Müller et al. 2020)
ARHGAP40 (Müller et al. 2020)
ARHGAP45 (Müller et al. 2020)
DEPDC1 (Müller et al. 2020)
INPP5B (Müller et al. 2020)
MYO9A (Müller et al. 2020; Bagci et al. 2020: no binding to active RAC1)
OCRL (Erdmann et al. 2007; Lichter Konecki et al. 2006; Müller et al. 2020; Bagci et al. 2020: no binding to active RAC1)
STARD8 (Kawai et al. 2007; Amin et al. 2016; Müller et al. 2020)
STARD13 (Ching et al. 2003; Amin et al. 2016; Müller et al. 2020)
SYDE1 (Müller et al. 2020; Bagci et al. 2020: no binding to active RAC1)
Identifier: R-HSA-8981637
Species: Homo sapiens
Compartment: cytosol, plasma membrane
The following GTPase activating proteins (GAPs) were shown to bind RHOA and stimulate its GTPase activity, resulting in GTP to GDP hydrolysis and conversion of the active RHOA:GTP complex into the inactive RHOA:GDP complex (the high throughput study by Bagci et al. 2020 looked at preferential binding of GAPs to active RHOA mutant compared to wild type RHOA but did not examine activation of GTPase activity):
ARHGAP5 (Burbelo et al. 1995; Kusama et al. 2006; Amin et al. 2016; Müller et al. 2020; supported by Bagci et al. 2020)
ARHGAP6 (Prakash et al. 2000; Müller et al. 2020)
ARHGAP8 (Lua and Low 2004; Müller et al. 2020)
ARHGAP10 (Shibata et al. 2001; Müller et al. 2020)
ARHGAP11A (Lawson et al. 2016; Müller et al. 2020)
ARHGAP11B (Müller et al. 2020)
ARHGAP19 (David et al. 2014; Müller et al. 2020)
ARHGAP20 (Müller et al. 2020)
ARHGAP21 (Sousa et al. 2005; Lazarini et al. 2013; Müller et al. 2020; supported by Bagci et al. 2020)
ARHGAP23 (Müller et al. 2020)
ARHGAP26 (Hildebrand et al. 1996; Sheffield et al. 1999; Amin et al. 2016; Müller et al. 2020)
ARHGAP28 (Yeung et al. 2014; Müller et al. 2020)
ARHGAP29 (Saras et al. 1997; Müller et al. 2020; supported by Bagci et al. 2020)
ARHGAP30 (Naji et al. 2011; Müller et al. 2020)
ARHGAP40 (Müller et al. 2020)
DLC1 (Healy et al. 2008; Amin et al. 2016; Müller et al. 2020)
GMIP (Aresta et al. 2002; Müller et al. 2020)
HMHA1 (de Kreuk et al. 2013)
MYO9A (Handa et al. 2013; Omelchenko and Hall 2012; Müller et al. 2020; supported by Bagci et al. 2020)
MYO9B (Post et al. 1998; Graf et al. 2000; Kong et al. 2015; Müller et al. 2020; supported by Bagci et al. 2020)
TAGAP (Bauer et al. 2005; Müller et al. 2020)

The following GAPs were shown to bind RHOA and stimulate its GTPase activity in some but not all studies and are annotated as candidate RHOA GAPs:
ABR (Bagci et al. 2020: binding to active RHOA; Chuang et al. 1995, Amin et al. 2016, Müller et al. 2020: no activation of RHOA GTPase activity)
ARAP1 (Miura et al. 2002: activation of RHOA GTPase activity; Müller et al. 2020: no activation of RHOA GTPase activity)
ARAP2 (Müller et al. 2020: activation of RHOA GTPase activity; Yoon et al. 2006: no activation of RHOA GTPase activity; Bagci et al. 2020: no binding to active RHOA)
ARAP3 (Krugmann et al. 2002: activation of RHOA GTPase activity; Müller et al. 2020: no activation of RHOA GTPase activity; Bagci et al. 2020: no binding to active RHOA)
ARHGAP1 (Zhang and Zheng 1998, Amin et al. 2016, Müller et al. 2020: activation of RHOA GTPase activity; Bagci et al. 2020: binding to active RHOA; Yang et al. 2006, Li et al. 2009: no activation of RHOA GTPase activity)
ARHGAP4 (Vogt et al. 2007: activation of RHOA GTPase activity; Müller et al. 2020: no activation of RHOA GTPase activity)
ARHGAP9 (Furukawa et al. 2001: activation of RHOA GTPase activity; Müller et al. 2020: no activation of RHOA GTPase activity)
ARHGAP18 (Maeda et al. 2011: activation of RHOA GTPase activity; Müller et al. 2020: no activation of RHOA GTPase activity)
ARHGAP22 (Müller et al. 2020: activation of RHOA GTPase activity; Mori et al. 2014: no activation of RHOA GTPase activity)
ARHGAP24 (Su et al. 2004: activation of RHOA GTPase activity; Lavelin and Geiger 2005, Ohta et al. 2006, Müller et al. 2020: no activation of RHOA GTPase activity)
ARHGAP31 (Müller et al. 2020: activation of RHOA GTPase activity; Tcherkezian et al. 2006: no activation of RHOA GTPase activity; Bagci et al. 2020: no binding to active RHOA)
ARHGAP32 (Nakazawa et al. 2003: activation of RHOA GTPase activity; Bagci et al. 2020: binding to active RHOA; Müller et al. 2020: no activation of RHOA GTPase activity)
ARHGAP35 (Levay et al. 2009, Amin et al. 2016; Müller et al. 2020: activation of RHOA GTPase activity; Bagci et al. 2020: no binding to active RHOA)
ARHGAP39 (Bagci et al. 2020: binding to active RHOA; Lundstrom et al. 2004, Müller et al. 2020: no activation of RHOA GTPase activity)
ARHGAP42 (Bai et al. 2013, Luo et al. 2017, Bai et al. 2017: activation of RHOA GTPase activity; Bagci et al. 2020: no binding to active RHOA)
ARHGAP44 (Raynaud et al. 2014: activation of RHOA GTPase activity; Müller et al. 2020: no activation of RHOA GTPase activity)
BCR (Zhang and Zheng 1998: activation of RHOA GTPase activity; Bagci et al. 2020: binding to active RHOA; Chuang et al. 1995, Müller et al. 2020: no activation of RHOA GTPase activity),
DEPDC1B (Bagci et al. 2020: binding to active RHOA; Wu et al. 2015, Müller et al. 2020: no activation of RHOA GTPase activity)
FAM13A (Li et al. 2015: activation of RHOA GTPase activity; Müller et al. 2020: no activation of RHOA GTPase activity)
OPHN1 (Elvers et al. 2012, Amin et al. 2016: activation of RHOA GTPase activity; Müller et al. 2020: no activation of RHOA GTPase activity; Bagci et al. 2020: no binding to active RHOA)
PIK3R1 (Bagci et al. 2020: binding to active RHOA; Müller et al. 2020: no activation of RHOA GTPase activity)
PIK3R2 (Bagci et al. 2020: binding to active RHOA; Müller et al. 2020: no activation of RHOA GTPase activity)
RACGAP1 (Toure et al. 1998; Amin et al. 2016: activation of RHOA GTPase activity; Müller et al. 2020: no activation of RHOA GTPase activity; Bagci et al. 2020: no binding to active RHOA)
SRGAP1 (Wong et al. 2001: activation of RHOA GTPase activity; Müller et al. 2020: no activation of RHOA GTPase activity)
STARD8 (Kawai et al. 2007, Müller et al. 2020: activation of RHOA GTPase activity; Amin et al. 2016: no activation of RHOA GTPase activity)
STARD13 (Ching et al. 2003, Leung et al. 2005, Müller et al. 2020: activation of RHOA GTPase activity; Amin et al. 2016: no activation of RHOA GTPase activity)

The following GAPs do not act on RHOA or were shown to not bind to active RHOA without testing for activation of RHOA GTPase activity:
ARHGAP12 (Müller et al. 2020; Bagci et al. 2020: no binding to RHOA)
ARHGAP15 (Seoh et al. 2003; Müller et al. 2020)
ARHGAP17 (Richnau and Aspenstrom 2001; Amin et al. 2016; Müller et al. 2020; Bagci et al. 2020: no binding to RHOA)
ARHGAP25 (Csepanyi Komi et al. 2012; Müller et al. 2020)
ARHGAP27 (Sakakibara et al. 2004; Müller et al. 2020)
ARHGAP33 (Liu et al. 2006; Müller et al. 2020)
ARHGAP36 (Müller et al. 2020)
ARHGAP45 (Müller et al. 2020)
CHN1 (Ahmed et al. 1994; Müller et al. 2020)
CHN2 (Caloca et al. 2003; Müller et al. 2020)
DEPDC1 (Müller et al. 2020)
FAM13B (Müller et al. 2020)
INPP5B (Müller et al. 2020)
OCRL (Lichter Konecki et al. 2006; Erdmann et al. 2007; Müller et al. 2020; Bagci et al. 2020: no binding to active RHOA)
RALBP1 (Jullien Flores et al. 1995; Müller et al. 2020)
SH3BP1 (Müller et al. 2020)
SRGAP2 (Mason et al. 2011; Müller et al. 2020; Bagci et al. 2020: no binding to active RHOA)
SRGAP3 (Endris et al. 2002; Müller et al. 2020)
SYDE1 (Müller et al. 2020; Bagci et al. 2020: no binding to active RHOA)
SYDE2 (Müller et al. 2020)
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