Search results for DPEP1

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LTD4 is converted to LTE4 by DPEP1/2

Identifier: R-HSA-266012
Species: Homo sapiens
Compartment: plasma membrane, extracellular region
Another outer surface membrane-bound, homodimeric enzyme, dipeptidase, existing in two forms DPEP1 (Adachi et al. 1989) and DPEP2 (Lee et al. 1983, Raulf et al. 1987), further hydrolyses leukotriene D4 (LTD4) to leukotriene E4 (LTE4), cleaving a glycine residue in the process.

DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG

Identifier: R-HSA-5433067
Species: Homo sapiens
Compartment: plasma membrane, extracellular region
In the formation of mercapturic acid from glutathione conjugates, first a glutamate residue is hydrolysed from the conjugate then a glycine residue (Gly). The dipeptidases 1,2 and 3 (DPEP1,2,3) perform this second hydrolysis. They are membrane-bound, homodimeric enzymes which require zinc ions for activity. DPEP1 has been characterised (Satoh et al. 1993, 1994, Nitanai et al. 2002) whereas DPEP2 and 3 are thought to function as DPEP1 based on similarity.
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