Search results for DUS2

Showing 10 results out of 10

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Species

Types

Compartments

Reaction types

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Protein (1 results from a total of 1)

DUS2

Identifier: R-HSA-6782261
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: DUS2: Q9NX74

Reaction (2 results from a total of 2)

DUS2 binds PKR

Identifier: R-HSA-9835385
Species: Homo sapiens
Compartment: cytosol
Human tRNA-dihydrouridine synthase-2 (DUS2) binds to protein kinase R (PKR, EIF2AK2) and inhibits its activation. Inhibition of PKR by DUS2 plays an important role in regulating stress-induced apoptosis (Mittelstadt et al, 2007).

DUS2:EPRS reduces uridine to dihydrouridine in tRNAs

Identifier: R-HSA-6782296
Species: Homo sapiens
Compartment: cytosol
DUS2 catalyzes the reduction of the 5,6 double bond in uridine residues in the D-loop of tRNAs, yielding 5,6-dihydrouridine (Kato et al. 2005). By inference with the homolog from Saccharomyces cerevisiae, Smm1p (Dus2p), NADH or NADPH is the reducing agent.

Complex (2 results from a total of 2)

DUS2:EIF2AK2

Identifier: R-HSA-9835379
Species: Homo sapiens
Compartment: cytosol

DUS2:EPRS

Identifier: R-HSA-6782346
Species: Homo sapiens
Compartment: cytosol

Interactor (4 results from a total of 4)

DUS23

Identifier: Q9BVJ7
Species: Homo sapiens
Primary external reference: UniProt: Q9BVJ7

DUS26

Identifier: Q9BV47
Species: Homo sapiens
Primary external reference: UniProt: Q9BV47

DUS21

Identifier: Q9H596
Species: Homo sapiens
Primary external reference: UniProt: Q9H596

DUS29

Identifier: Q68J44
Species: Homo sapiens
Primary external reference: UniProt: Q68J44

Icon (1 results from a total of 1)

DUS2

Species: Homo sapiens
Curator: Bruce May
Designer: Cristoffer Sevilla
DUS2 icon
tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
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