Search results for EIF2S2

Showing 6 results out of 6

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Species

Types

Compartments

Reaction types

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Protein (1 results from a total of 1)

Identifier: R-HSA-72512
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: EIF2S2: P20042

Complex (3 results from a total of 3)

Identifier: R-HSA-72515
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-9633006
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-5226905
Species: Homo sapiens
Compartment: cytosol

Reaction (1 results from a total of 1)

Identifier: R-HSA-5227009
Species: Homo sapiens
Compartment: cytosol
ATP-binding cassette sub-family F member 1 (ABCF1 aka ABC50) is unlike most ABC proteins in that it does not possess membrane-spanning domains. ABCF1 interacts with eukaryotic initiation factor 2 complex (EIF2S1:EIF2S2:EIF2S3), a key player in translation initiation and control and in ribosome regulation. ABCF1 is predominantly located in the cytosol, whereas a smaller amount is also found in the nucleoplasm but not in the nucleolus. Knockout of ABCF1 impaired translation of both cap-dependent and cap-independent reporters, consistent with a positive role for ABCF1 in the function of the EIF2 complex (Paytubi et al. 2008, Paytubi et al. 2009).

Icon (1 results from a total of 1)

Species: Homo sapiens
Curator: Bruce May
Designer: Cristoffer Sevilla
EIF2S2 icon
Eukaryotic translation initiation factor 2 subunit 2
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