Search results for EIF5A

Showing 14 results out of 14

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Species

Types

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Protein (6 results from a total of 6)

Identifier: R-HSA-3006308
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: P63241
Identifier: R-HSA-3006309
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: EIF5A: P63241
Identifier: R-HSA-3006310
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: P63241
Identifier: R-HSA-204612
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: Q9GZV4
Identifier: R-HSA-3149584
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: EIF5A2: Q9GZV4
Identifier: R-HSA-204650
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: Q9GZV4

Set (3 results from a total of 3)

Identifier: R-HSA-3149585
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-3149583
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-204658
Species: Homo sapiens
Compartment: cytosol

Reaction (3 results from a total of 3)

Identifier: R-HSA-204617
Species: Homo sapiens
Compartment: cytosol
Cytosolic deoxyhypusine synthase (DHPS) tetramer catalyzes the reaction of the deoxyhypusine (Dhp) residue in EIF5A protein (Dhp-K50-EIF5A) with 1,3 diaminopropane, NADH and H+ to form EIF5A, spermidine (SPM), and NAD+ (Park et al. 2003; Park 2006). While this reaction is readily observed in vitro, it is probably minimized by the rapid, irreversible conversion of EIF5A Dhp residues to hypusine.
Identifier: R-HSA-204647
Species: Homo sapiens
Compartment: cytosol
Cytosolic deoxyhypusine synthase (DHPS) tetramer catalyzes the reaction of of EIF5A protein, spermidine (SPM), and NAD+ to convert lysine 50 of EIF5A to deoxyhypusine (Dhp), generating 1,3 diaminopropane, NADH and H+ in the process (Clement et al. 2003; Joe et al. 1995; Park 2006; Wolff et al. 1997). Although the reaction is reversible, the reverse reaction is probably minimized under physiological conditions by the rapid, irreversible conversion of EIF5A Dhp residues to hypusine.
Identifier: R-HSA-204662
Species: Homo sapiens
Compartment: cytosol
Cytosolic deoxyhypusine hydroxylase (DOHH) complexed with Fe2+ catalyzes the irreversible hydroxylation of peptidyl deoxyhypusine (Dhp-K50-EIF5A) to peptidyl hypusine (Hyp-K50-EIF5A) using molecular oxygen. The only known substrate for this enzyme is the modified lysine at residue 50 of the two isoforms of eIF5A (Clement et al. 2003; Kang et al. 2007; Kim et al. 2006).

Pathway (2 results from a total of 2)

Identifier: R-HSA-204626
Species: Homo sapiens
Compartment: cytosol
Cytosolic eukaryotic translation initiation factor 5A (eIF5A) undergoes a unique two-step post-translational modification at Lys 50 via deoxyhypusine (Dhp) to hypusine (Hyp). In the first step deoxyhypusine synthase transfers the aminobutyl group of spermidine to the epsilon-amino group of lysine 50, using NAD+ as a cofactor. Hydroxylation of the C2 of the newly added moiety in the second step is catalyzed by deoxyhypusine hydroxylase/monooxygenase with molecular oxygen as the source. The molecular function of eIF5A is unknown, but the protein is required for viability in eukaryotic cells and its normal function requires hypusinylation. eIF5A is the only protein known to undergo hypusinylation (Park 2006).
Identifier: R-HSA-163841
Species: Homo sapiens
After translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the body. These modifications include the vitamin K-dependent attachment of carboxyl groups to glutamate residues and the conversion of a lysine residue in eIF5A to hypusine, and the conversion of a histidine residue in EEF to diphthamide.
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