Search results for ELAVL1

Showing 9 results out of 9

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Species

Types

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Protein (6 results from a total of 6)

Identifier: R-HSA-450601
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: ELAVL1: Q15717
Identifier: R-HSA-450582
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: Q15717
Identifier: R-HSA-450576
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: ELAVL1: Q15717
Identifier: R-HSA-450532
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: Q15717
Identifier: R-HSA-450448
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: Q15717
Identifier: R-HSA-450376
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: Q15717

Pathway (1 results from a total of 1)

Identifier: R-HSA-450520
Species: Homo sapiens
Compartment: cytosol, nucleoplasm
HuR (ELAVL1) is a ubiquitous protein that binds AU-rich elements in mRNAs and acts to stabilize the mRNAs. HuR activity is controlled by phosphorylation, with PKC alpha and PCK delta enhancing the ability of HuR to bind and stabilize mRNAs. Binding of mRNAs occurs in the nucleus and HuR then interacts with the CRM1 export pathway to transfer the mRNA to the cytoplasm. The mechanism by which HuR shields the mRNA from degradation is unknown.
HuR also regulates translation of some mRNAs, in some cases repressing translation and in some cases enhancing translation of bound mRNAs by recruiting them to polysomes.
HuR binds and regulates mRNAs encoding Cyclooxygenase-2 (COX2, PTGS2), Cyclin A (CCNA, CCNA2), Cyclin D1 (CCND1), Cyclin B1 (CCNB1), CD83 antigen (CD83), and proto-oncogene c-Fos (FOS).
HuR is a member of a family of proteins that also contains HuD (ELAVL4), HuB (ELAVL2), and HuC (ELAVL3). HuB, HuC, and HuD are specifically expressed in neural tissue.
HuR participates in apoptosis. During lethal stress HuR becomes mostly cytoplasmic and is a target of Caspase-3 and Caspase-7. The cleavage products of HuR in turn promote apoptosis.

Reaction (2 results from a total of 2)

Identifier: R-HSA-450550
Species: Homo sapiens
Compartment: nucleoplasm
Protein kinase C alpha (PKCalpha) phosphorylates HuR (ELAVL1) on serine221 and serine 158.
Identifier: R-HSA-450533
Species: Homo sapiens
Compartment: nucleoplasm
Protein kinase C delta (PKCdelta) phosphorylates HuR (ELAVL1) at serine 221 and serine 318.
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