Search results for ENTPD1

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Protein (1 results from a total of 1)

Identifier: R-HSA-913566
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: ENTPD1: P49961

Complex (2 results from a total of 2)

Identifier: R-HSA-8850847
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-HSA-8850845
Species: Homo sapiens
Compartment: plasma membrane

Reaction (2 results from a total of 2)

Identifier: R-HSA-8850854
Species: Homo sapiens
Compartment: plasma membrane, extracellular region
NTPDase1 (CD39), a plasma membrane-bound nucleotide phosphatase encoded by the ENTPD1 gene, hydrolyzes extracellular NDPs to corresponding NMPs (Lemmens et al. 2000, Kukulski et al. 2005) which contributes to inhibition of platelet aggregation and thrombosis (Kaczmarek et al. 1996, Enjyoji et al. 1999, Marcus et al. 2003).
Identifier: R-HSA-8850846
Species: Homo sapiens
Compartment: extracellular region, plasma membrane
NTPDase1 (CD39) is a plasma membrane-bound ectonucleotidase encoded by the ENTPD1 gene that hydrolyzes extracellular NTPs to NMPs, via corresponding NDP intermediates (Lemmens et al. 2000, Kukulski et al. 2005). NTPDase1 is expressed on endothelial cells, smooth muscle cells and most leukocytes. The vascular endothelial NTPDase1 regulates platelet aggregation and thrombosis (Kaczmarek et al. 1996, Enjoyji et al. 1999). In mice, NTPDase1 is expressed at the surface of epidermal dendritic cells (Langerhans cells) and is involved in regulation of immune response to skin irritants (Mizumoto et al. 2002). NTPDase1 expressed in vascular smooth muscle cells regulates vasomotion (Kauffenstein et al. 2010, reviewed by Kukulski et al. 2011). In regulatory T lymphocytes (Tregs) and other leukocytes NTPDase1 regulates inflammatory processes (Deaglio et al. 2007).

Pathway (1 results from a total of 1)

Identifier: R-HSA-8850843
Species: Homo sapiens
The ectonucleoside triphosphate diphosphatase (E-NTPDase family) of ectonucleotidases includes 8 enzymes: NTPDase1 (encoded by the ENTPD1 gene), NTPDase2 (encoded by the ENTPD2 gene), NTPDase3 (encoded by the ENTPD3 gene), NTPDase4 (encoded by the ENTPD4 gene), NTPDase5 (encoded by the ENTPD5 gene), NTPDase6 (encoded by the ENTPD6 gene), NTPDase7 (encoded by the ENTPD7 gene) and NTPDase8 (encoded by the ENTPD8 gene). NTPDases hydrolyze nucleoside triphosphates and nucleoside diphosphates, producing the corresponding nucleoside monophosphates as final products. Different family members show different specificity for particular nucleotides. NTPDases are involved in various biological processes, such as hemostasis, immune response and development of the nervous system.
The catalytic domain of NTPDases is contained within the loop formed by a cluster of apyrase conserved regions (ACRs). All family members require divalent cations, such as calcium (Ca2+) or magnesium (Mg2+) ions, for catalytic activity. The hydrolysis involves a nucleophilic attack of a water molecule on the terminal phosphate of a nucleotide substrate.
All E-NTPDase family members are transmembrane proteins, associated with either plasma membrane (NTPDase1, NTPDase2, NTPDase3 and NTPDase8) or organelle membranes (NTPDase4 and NTPDase7). Two family members, NTPDase5 and NTPDase6, can be secreted into extracellular space following a proteolytic cleavage from the plasma membrane. NTPDases hydrolyze exocytoplasmic nucleotides, thus regulating the availability of ligands for purinergic receptors. Glycosylation and oligomerization are involved in the regulation of NTPDases, but have not been thoroughly studied.

For reviews of the NTPDase family, please refer to Robson et al. 2006 and Zimmermann et al. 2012.

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