Search results for ENTPD8

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Protein (1 results from a total of 1)

Identifier: R-HSA-3902506
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: ENTPD8: Q5MY95

Complex (1 results from a total of 1)

Identifier: R-HSA-8851542
Species: Homo sapiens
Compartment: plasma membrane

Reaction (2 results from a total of 2)

Identifier: R-HSA-8851550
Species: Homo sapiens
Compartment: extracellular region, plasma membrane
NTPDase8, encoded by the ENTPD8 gene, is the main liver ectonucleotide phosphatase. NTPDase8 belongs to the E-NTPDase family of nucleotide phosphatases and can hydrolyze NDPs to corresponding NMPs (Sévigny et al. 2000, Bigonnesse et al. 2004, Fausther et al. 2007).
Identifier: R-HSA-8851538
Species: Homo sapiens
Compartment: extracellular region, plasma membrane
NTPDase8, encoded by the ENTPD8 gene, is an E-NTPDase family ectonucleotide phosphatase that, in the presence of Ca2+ or Mg2+, hydrolyzes NTPs to NMPs, via corresponding NDP intermediates. NTPDase8 is more efficient in hydrolyzing NTPs than NDPs. NTPDase8 provides the main ectonucleotide phosphatase activity in rat and porcine livers (Sevigny et al. 2000, Fausther et al. 2007).

Pathway (1 results from a total of 1)

Identifier: R-HSA-8850843
Species: Homo sapiens
The ectonucleoside triphosphate diphosphatase (E-NTPDase family) of ectonucleotidases includes 8 enzymes: NTPDase1 (encoded by the ENTPD1 gene), NTPDase2 (encoded by the ENTPD2 gene), NTPDase3 (encoded by the ENTPD3 gene), NTPDase4 (encoded by the ENTPD4 gene), NTPDase5 (encoded by the ENTPD5 gene), NTPDase6 (encoded by the ENTPD6 gene), NTPDase7 (encoded by the ENTPD7 gene) and NTPDase8 (encoded by the ENTPD8 gene). NTPDases hydrolyze nucleoside triphosphates and nucleoside diphosphates, producing the corresponding nucleoside monophosphates as final products. Different family members show different specificity for particular nucleotides. NTPDases are involved in various biological processes, such as hemostasis, immune response and development of the nervous system.
The catalytic domain of NTPDases is contained within the loop formed by a cluster of apyrase conserved regions (ACRs). All family members require divalent cations, such as calcium (Ca2+) or magnesium (Mg2+) ions, for catalytic activity. The hydrolysis involves a nucleophilic attack of a water molecule on the terminal phosphate of a nucleotide substrate.
All E-NTPDase family members are transmembrane proteins, associated with either plasma membrane (NTPDase1, NTPDase2, NTPDase3 and NTPDase8) or organelle membranes (NTPDase4 and NTPDase7). Two family members, NTPDase5 and NTPDase6, can be secreted into extracellular space following a proteolytic cleavage from the plasma membrane. NTPDases hydrolyze exocytoplasmic nucleotides, thus regulating the availability of ligands for purinergic receptors. Glycosylation and oligomerization are involved in the regulation of NTPDases, but have not been thoroughly studied.

For reviews of the NTPDase family, please refer to Robson et al. 2006 and Zimmermann et al. 2012.

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