Search results for EP300
Showing 5 results out of 177
Reaction (5 results from a total of 99)
Identifier: R-HSA-5250930
Species:
Homo sapiens
Compartment:
nucleoplasm
Direct interactions between BAZ1B (WSTF) and histone acetyltransferases KAT2B, KAT2A, and EP300 are weak (Vintermist et al. 2011) so the acetyltransferases may interact with other subunits of B‑WICH or with proteins not in the B‑WICH complex. The ERCC6 (CSB) component of B‑WICH and MYOIC interact with KAT2B (PCAF) (Sarshad et al. 2013, Shen et al. 2013). The histone acetyltransferases are believed to acetylate histone H3 at lysine‑9 in rDNA since this modification is reduced in WSTF and MYOIC knockdown cells (Vintermist et al. 2011, Sarshad et al. 2013). Knockdown of KAT2B causes loss of acetylation on histone H4 and on histone H3 at lysine‑9 (Shen et al. 2013).
Identifier: R-HSA-9617853
Species:
Homo sapiens
Compartment:
nucleoplasm
GADD45A gene transcription is stimulated by FOXO1, FOXO3 and FOXO4 (Tran et al. 2002, Furukawa-Hibi et al. 2002, Hughes et al. 2011, Sengupta et al. 2011, Ju et al. 2014). Direct transcriptional regulation was demonstrated for FOXO3 (Tran et al. 2002, Furukawa-Hibi et al. 2002) and FOXO4 (Furukawa-Hibi et al. 2002). Acetylation of FOXO4 by EP300 (p300) or CREBBP (CBP) in response to oxidative stress interferes with FOXO4-mediated induction of GADD45A gene transcription (Dansen et al. 2009). Under oxidative stress, deacetylation of FOXO3 by SIRT1 deacetylase promotes FOXO3-mediated induction of GADD45A gene transcription (Brunet et al. 2004).
Identifier: R-HSA-3857305
Species:
Homo sapiens
Compartment:
nucleoplasm
RSK6A1/2/3-mediated phosphorylation of CEBPB downstream of activated RAS stimulates CEBPB homodimerization and DNA binding (Lee, Shuman et al. 2010) and, specifically, RAS-induced CEBPB activation stimulates CEBPB binding to the IL6 promoter (Kuilman et al. 2008; Lee, Shuman et al. 2010). RAS-activated CEBPB is able to recruit additional transcription activators, such as EP300, to the IL6 promoter (Lee, Miller et al. 2010). NFKB transcription complex, activated by interleukin-1-alpha (IL1A) signaling (Jimi et al. 1996, Hartupee et al. 2008, Orjalo et al. 2009), also binds the promoter of the IL6 gene (Shimizu et al. 1990, Libermann and Baltimore 1990) and cooperates with CEBPB in the activation of IL6 transcription (Matsusaka et al. 1993).
Identifier: R-HSA-549475
Species:
Homo sapiens
Compartment:
nucleoplasm
The NR1D1 (REV-ERBA) gene is transcribed to yield mRNA and the mRNA is translated to yield NR1D1 protein (Miyajima et al. 1989, Adelmant et al. 1996, also inferred from mouse homologs). In mouse the Rev-erba gene shows circadian expression due to transactivation by the BMAL1:CLOCK (ARNTL:CLOCK) heterodimer. REV-ERBA binds the promoter of its own gene and represses its own expression (Adelmant et al. 1996).
Activation of NR1D1 (REV-ERBA) expression by phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) is inferred from mouse. NPAS2 is predicted to act redundantly with CLOCK.
As inferred from mouse, RORA binds RRE DNA elements and recruits the coactivators PGC-1alpha (PPARGC1A) and p300 (EP300, a histone acetylase). RORA binds the NR1D1 (REV-ERBA) promoter and activates transcription.
Activation of NR1D1 (REV-ERBA) expression by phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) is inferred from mouse. NPAS2 is predicted to act redundantly with CLOCK.
As inferred from mouse, RORA binds RRE DNA elements and recruits the coactivators PGC-1alpha (PPARGC1A) and p300 (EP300, a histone acetylase). RORA binds the NR1D1 (REV-ERBA) promoter and activates transcription.
Identifier: R-HSA-9759141
Species:
Homo sapiens
Compartment:
nucleoplasm
The NQO1 gene encodes an NAD(P)H dehydrogenase quinone 1 enzyme. NQO1 is one of a number of drug metabolism genes upregulated by the NFE2L2:KEAP1 pathway in response to oxidative stress and a chemically diverse group of compounds now known as "phase II inducers" (Rangsamy et al, 2004; Malhotra et al, 2010; reviewed in Baird and Yamamoto, 2000). NFE2L2 binds to the anti-oxidant response element (ARE) as a heterodimer with small MAF proteins like MAFK and upregulates NQO1 expression (Itoh et al, 1997; McMahon et al, 2001; Rangasamy et al, 2004; Malhotra et al, 2010). Binding and transcriptional activation by NFE2L2 at the NQO1 promoter is enhanced by CREBBP or EP300-mediated acetylation of NFE2L2 at 18 sites in the N-terminal Neh1 domain (Sun et al, 2009).
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