Search results for FAM83A

Showing 28 results out of 36

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Species

Types

Compartments

Search properties

Protein (7 results from a total of 8)

Identifier: R-HSA-9851391
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: FAM83A: Q86UY5
Identifier: R-MMU-9851391
Species: Mus musculus
Compartment: cytosol
Primary external reference: UniProt: Q8K2P2
Identifier: R-SSC-9851391
Species: Sus scrofa
Compartment: cytosol
Primary external reference: UniProt: F1RR13
Identifier: R-CFA-9851391
Species: Canis familiaris
Compartment: cytosol
Primary external reference: UniProt: A0A8I3N6W9
Identifier: R-BTA-9851391
Species: Bos taurus
Compartment: cytosol
Primary external reference: UniProt: E1BMR2
Identifier: R-RNO-9851391
Species: Rattus norvegicus
Compartment: cytosol
Primary external reference: UniProt: D3ZQN0
Identifier: R-XTR-9851391
Species: Xenopus tropicalis
Compartment: cytosol
Primary external reference: UniProt: Q66JF7

Set (7 results from a total of 9)

Identifier: R-HSA-9851390
Species: Homo sapiens
Compartment: cytosol
Identifier: R-MMU-9851390
Species: Mus musculus
Compartment: cytosol
Identifier: R-RNO-9851390
Species: Rattus norvegicus
Compartment: cytosol
Identifier: R-XTR-9851390
Species: Xenopus tropicalis
Compartment: cytosol
Identifier: R-DRE-9851390
Species: Danio rerio
Compartment: cytosol
Identifier: R-GGA-9851390
Species: Gallus gallus
Compartment: cytosol
Identifier: R-BTA-9851390
Species: Bos taurus
Compartment: cytosol

Complex (7 results from a total of 9)

Identifier: R-HSA-9851427
Species: Homo sapiens
Compartment: plasma membrane
Identifier: R-MMU-9851427
Species: Mus musculus
Compartment: plasma membrane
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Identifier: R-BTA-9851427
Species: Bos taurus
Compartment: plasma membrane
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Identifier: R-RNO-9851427
Species: Rattus norvegicus
Compartment: plasma membrane
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Identifier: R-XTR-9851427
Species: Xenopus tropicalis
Compartment: plasma membrane
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Identifier: R-DRE-9851427
Species: Danio rerio
Compartment: plasma membrane
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Identifier: R-SSC-9851427
Species: Sus scrofa
Compartment: plasma membrane
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Reaction (7 results from a total of 10)

Identifier: R-HSA-9851407
Species: Homo sapiens
Compartment: cytosol, plasma membrane
Both recombinant and endogenous EGFR and FAM83B form a complex. The lysine residue K230 of FAM83B, conserved in other FAM83 family members, including FAM83A and FAM83D, is needed for binding to EGFR and stimulation of EGFR signaling. Through a mechanism that has not been elucidated, FAM83B stimulates basal and EGF-induced EGFR trans-autophosphorylation but dissociates from autophosphorylated EGFR (Cipriano et al. 2014).

FAM83B overexpression stimulates activation of MAPK and mTOR signaling downstream of EGFR, and prolongs activating EGFR, AKT and MAPK phosphorylation, increasing resistance to EGFR-targeting tyrosine kinase inhibitors (TKIs) AG1478, erlotinib, and CL387785 (Cipriano et al. 2012).

FAM83A overexpression similarly increases resistance of EGFR to EGFR-targeting TKIs AG1478, lapatinib, and gefitinib. In EGF-treated cells, tyrosine phosphorylation of FAM83A is increased, plausibly directly by EGFR, but the physical interaction between FAM83A and EGFR has not been reported. Downstream of EGFR activation, FAM83A associates with CRAF and PIK3R1. EGF treatment is not needed for FAM83A to interact with CRAF and PIK3R1 when FAM83A is overexpressed (Lee et al. 2012).

FAM83A-AS1 lncRNA, which is known to increase FAM83A expression, positively regulates EGFR signaling (Zhao et al. 2022).

FAM83D is highly expressed in invasive epithelial ovarian cancer. FAM83D-overexpressing cells demonstrate increased tyrosine phosphorylation of EGFR, as well as increased activating phosphorylation of downstream effectors of EGFR such as CRAF, ERK1/2 (MAPK3/1), and AKT (Zhang et al. 2019), but the direct interaction of FAM83D and EGFR has not been reported.

FAM83A and FAM83D are annotated as candidate binding partners or EGFR.
Identifier: R-MMU-9851407
Species: Mus musculus
Compartment: cytosol, plasma membrane
This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Identifier: R-RNO-9851407
Species: Rattus norvegicus
Compartment: cytosol, plasma membrane
This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Identifier: R-CFA-9851407
Species: Canis familiaris
Compartment: cytosol, plasma membrane
This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Identifier: R-BTA-9851407
Species: Bos taurus
Compartment: cytosol, plasma membrane
This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Identifier: R-SSC-9851407
Species: Sus scrofa
Compartment: cytosol, plasma membrane
This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Identifier: R-DRE-9851407
Species: Danio rerio
Compartment: cytosol, plasma membrane
This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

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