Search results for FAR2

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Species

Types

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Reaction types

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Species

Types

Compartments

Reaction types

Search properties

Protein (1 results from a total of 1)

Identifier: R-HSA-390430
Species: Homo sapiens
Compartment: peroxisomal membrane
Primary external reference: UniProt: FAR2: Q96K12

Reaction (1 results from a total of 1)

Identifier: R-HSA-390438
Species: Homo sapiens
Compartment: peroxisomal matrix
Peroxisomal fatty acyl-CoA reductase 2 (FAR2) catalyzes the reaction of palmitoyl-CoA (PalmCoA) and 2 NADPH + 2 H+ to form hexadecanol (HXOL), CoASH, and 2 NADP+. As judged from mRNA levels, FAR2 is not widely expressed in the body but is abundant in brain (Cheng and Russell 2004).

Pathway (1 results from a total of 1)

Identifier: R-HSA-9640463
Species: Homo sapiens
Waxes are esters of long chain fatty acids and long chain fatty alcohols that play an important role in protecting the skin surface from drying and abrasion. Enzymes that catalyze two reactions of wax biosynthesis have been characterized in humans. FAR1 and FAR2 catalyze the reduction of fatty acids to fatty alcohols in the peroxisome and AWAT1 and AWAT2 catalyze the reaction of fatty alcohols and acyl-CoA in the cytosol to form wax esters. The existence of a transport process, otherwise uncharacterized, to move fatty alcohols from the peroxisome to the cytosol is inferred from the observation that cultured cells that do not normally synthesize waxes can be induced to do so by co-transfection with DNA constructs encoding FAR and AWAT enzymes (Cheng & Russell 2004a,b).
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