Search results for FBXO5

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Reaction (4 results from a total of 4)

Identifier: R-HSA-8961699
Species: Homo sapiens
Compartment: nucleoplasm
E2F1 directly stimulates transcription of the FBXO5 (Emi1) gene (Hsu et al. 2002).
Identifier: R-HSA-8961688
Species: Homo sapiens
Compartment: nucleoplasm
E2F1 binds to E2F binding sites in the promoter of the FBXO5 (Emi1) gene (Hsu et al. 2002).
Identifier: R-HSA-68825
Species: Homo sapiens
Compartment: cytosol
APC/C-dependent degradation of geminin (GMNN) was first demonstrated in Xenopus (McGarry and Kirschner 1998) and was shown to be proteasome-dependent and sensitive to FBXO5 (Emi1)-mediated inhibition of the APC/C:Cdh1 activity in human cells (Machida and Dutta 2007).
Identifier: R-HSA-68712
Species: Homo sapiens
Compartment: cytosol
From the end of anaphase and throughout G1, the Cdh1 (FZR1) containing anaphase-promoting complex (APC/C:Cdh1) ubiquitinates geminin (GMNN), targeting it for degradation and enabling release of CDT1 and the subsequent association of CDT1 with the replication origins.The presence of an APC destruction box in geminin and its APC/C-mediated ubiquitination and degradation was first demonstrated in Xenopus egg extracts (McGarry and Kirschner 1998) and was later confirmed in human cells, where it was shown to largely depend on Cdh1 and not Cdc20 component of the APC/C (Pfleger et al. 2001; Di Fiore and Pines 2007; Machida and Dutta 2007). Emi1 (FBXO5) mediated inhibition of the APC/C:Cdh1 complex in S and G2 phases is needed for stabilization of geminin and prevention of re-replication (Di Fiore and Pines 2007; Machida and Dutta 2007).
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