Search results for FECH

Showing 3 results out of 3

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Species

Types

Compartments

Reaction types

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Species

Types

Compartments

Reaction types

Search properties

Protein (1 results from a total of 1)

Identifier: R-HSA-189441
Species: Homo sapiens
Compartment: mitochondrial matrix
Primary external reference: UniProt: FECH: P22830

Reaction (1 results from a total of 1)

Identifier: R-HSA-189465
Species: Homo sapiens
Compartment: mitochondrial matrix
Ferrochelatase (FECH) catalyzes the insertion of ferrous iron into protoporphyrin IX (PRIN9) to form heme. FECH is localized on the matrix surface of the inner mitochondrial membrane and this reaction takes place within the mitochondrial matrix. The enzyme functions as a homodimer with each monomer containing a nitric oxide-sensitive 2Fe-2S cluster. Enzyme deficiency is associated with erythropoietic protoporphyria in vivo, and inhibition of ferrochelatase activity is a clinically important consequence of lead poisoning (Piomelli et al. 1987).

Complex (1 results from a total of 1)

Identifier: R-HSA-189402
Species: Homo sapiens
Compartment: mitochondrial matrix
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