Search results for FLI1

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Species

Types

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Protein (1 results from a total of 1)

Identifier: R-HSA-9616216
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: FLI1: Q01543

Complex (1 results from a total of 1)

Identifier: R-HSA-9616212
Species: Homo sapiens
Compartment: nucleoplasm

Reaction (3 results from a total of 3)

Identifier: R-HSA-9616214
Species: Homo sapiens
Compartment: nucleoplasm
The evolutionarily conserved upstream enhancer of the CEBPA gene binds RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, and MYB in hemopoietic progenitor cells and myeloid progenitor cells (inferred from mouse). Unlike the promoter of the mouse Cebpa gene, the human CEBPA promoter does not bind CEBPA and autoregulation of CEBPA occurs indirectly through CEBPA-stimulated binding of USF to the promoter of the CEBPA gene (Timchenko et al. 1995). As inferred from mouse homologs, RUNX1, GATA2, SCL, SPI1, and FLI1 bind concomitantly.
Identifier: R-HSA-9616243
Species: Homo sapiens
Compartment: nucleoplasm, cytosol
RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), MYB, and CEBPA itself all contribute to the level of transcription of CEBPA in hemopoietic progenitor cells and myeloid progenitor cells (inferred from mouse homologs). High levels of CEBPA appear to favor CEBPA:CEBPA homodimers and lead to granulopoiesis; low levels of CEBPA appear to favor CEBPA:AP-1 heterodimers and lead to monopoiesis. LEF1 also directly activates transcription of CEBPA (Skokowa et al. 2006, Skokowa et al. 2012), but appears to act at the transition of granulocyte-macrophage precursors to promyelocytes, a later stage of granulopoiesis.
The relative levels of SPI1 (PU.1) and CEBPA (SPI1 to CEBPA mRNA expression ratio) in granulocytic–macrophage progenitors have been suggested to regulate monocyte versus neutrophil cell-fate choice (Dahl et al. 2003).
Identifier: R-HSA-8956568
Species: Homo sapiens
Compartment: nucleoplasm
RUNX1, in complex with CBFB, binds to the core TAL1 complex consisting of TAL1 (SCL), TCF3 (E2A) or TCF12 (HEB), LMO1 or LMO2, LDB1 and GATA1, GATA2 or GATA3 (Wilson et al. 2010, Tijssen et al. 2011, Sanda et al. 2012, Mansour et al. 2014, Hoang et al. 2016). Assembly of the RUNX1- and GATA3-containing TAL1 complex is positively regulated by the CDK7-containing CAK complex (Kwiatkowski et al. 2014).
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